Protein Alignment Corin and PRSS50

DIOPT Version :10

• Sequence 1: NP_610297.2
• Gene: Corin / 35691
• FlyBaseID: FBgn0033192
• Length: 1397
• Species: Drosophila melanogaster
• Sequence 2: NP_037402.1
• Gene: PRSS50 / 29122
• HGNCID: 17910
• Length: 385
• Species: Homo sapiens
• Alignment Length: 357
• Identity: 91/357 - (25%)
• Similarity: 147/357 - (41%)
• Gaps: 66/357 - (18%)

  Fly  1012 WDRAVSPSAVCSI-LGYSAVNATSVLTQLTHRPLLATVNVSTDIWKMYAKR--KSTLMQEFANCK 1073
            |....:|.|:.:. ....:|......|..:.||.|        :|:....:  .||.|:
Human    38 WGAGEAPGALSTADPADQSVQCVPKATCPSSRPRL--------LWQTPTTQTLPSTTME------ 88

  Fly  1074 KTEDYPMAD------LTCS-NYECGRVKRGRHKPSRRIIGGTQASPGNWPFLAAILGGPEKIFYC 1131
              ..:|:::      .:|. :||.....|.....:||           ||::.::......|  |
Human    89 --TQFPVSEGKVDPYRSCGFSYEQDPTLRDPEAVARR-----------WPWMVSVRANGTHI--C 138

  Fly  1132 AGVLISDQWVLTASHCVGNYSVIDLEDWTIQLGVTRRNSFTYSGQKVKVKAVIPHPQYNMA---- 1192
            ||.:|:.|||||.:||:....||    :::::|....:..|.:...|.|..||.|.:|...
Human   139 AGTIIASQWVLTVAHCLIWRDVI----YSVRVGSPWIDQMTQTASDVPVLQVIMHSRYRAQRFWS 199

  Fly  1193 -IAHDNDIALFQLATRVAFHEHLLPVCLPPPSVRNLHPGTLCTVIGWG--KREDKDPKSTYEYIV 1254
             :...|||.|.:|...:.:..::.|:|||.... .|...:.|||.|||  |.:...|:..   .:
Human   200 WVGQANDIGLLKLKQELKYSNYVRPICLPGTDY-VLKDHSRCTVTGWGLSKADGMWPQFR---TI 260

  Fly  1255 NEVQVPIITRNQCDEWLDNLT--------VSEGMVCAGFDDGGKDACQGDSGGPLLCPYPGEKNR 1311
            .|.:|.|:...:||.:..|.|        :...|:||. |...:..|...:|.||:|...|   .
Human   261 QEKEVIILNNKECDNFYHNFTKIPTLVQIIKSQMMCAE-DTHREKFCYELTGEPLVCSMEG---T 321

  Fly  1312 WFVGGIVSWGIMCAHPRLPGVYANVVQYVPWI 1343
            |::.|:||||..|.....|.:|..|..|..||
Human   322 WYLVGLVSWGAGCQKSEAPPIYLQVSSYQHWI 353

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Corin	NP_610297.2	CRD_FZ	778..894	CDD:143549
		LDLa	911..942	CDD:238060
		LDLa	945..979	CDD:238060
		SR	980..>1034	CDD:214555	4/22 (18%)
		Tryp_SPc	1104..1346	CDD:238113	72/255 (28%)
PRSS50	NP_037402.1	Tryp_SPc	118..353	CDD:238113	72/259 (28%)