Protein Alignment Corin and F11

DIOPT Version :10

• Sequence 1: NP_610297.2
• Gene: Corin / 35691
• FlyBaseID: FBgn0033192
• Length: 1397
• Species: Drosophila melanogaster
• Sequence 2: NP_001398595.1
• Gene: F11 / 290757
• RGDID: 1309364
• Length: 622
• Species: Rattus norvegicus
• Alignment Length: 663
• Identity: 155/663 - (23%)
• Similarity: 234/663 - (35%)
• Gaps: 229/663 - (34%)

  Fly   834 LCTLFVPKCGQSGATVPPCKTLCTETMRRCGFFFDVFGLSLPEYLNCKLFKDF--PSSED----- 891
            |.|:|.|     .||.  |:.:||...|                  |.||...  .||:|
  Rat    35 LSTVFTP-----SATY--CQLVCTHHPR------------------CLLFTFMAESSSDDPTKWF 74

  Fly   892 -CVGLDEVREV-----MRAATHPKCDGF---QCDQ--NRCLPQEYVCDGHLD---------CMDQ 936
             |:..|.:.|.     |..|.    .|:   ||.|  :.|....||   :||         .:..
  Rat    75 ACILKDSLTETLPMVHMTGAV----SGYSFKQCPQQLSACSKNVYV---NLDMKGMNYNSSAVKN 132

  Fly   937 ADEAKCERCGPDEIYCGDSQC----IGTKHICDGIIDCPYGQDERNCLRLSERNGDVGTGVLEVY 997
            |.|.: |||      ..|:.|    ..|.|.       |.....:.||             |:..
  Rat   133 ARECQ-ERC------TNDAHCQFFTYATGHF-------PSVDHRKMCL-------------LKYT 170

  Fly   998 RIGQRQWMPACVKNWDRAVSPSAV--CSILGYSAV------------NATSVLTQ--------LT 1040
            ::|    .|..:...|..||..::  |.:...:.:            |..|||..        .|
  Rat   171 QMG----TPTSITKLDSVVSGFSLKSCGLSNLACIRDIFPNTVLADLNIDSVLAPDAFVCRRICT 231

  Fly  1041 HRPLLATVNVSTDIWKMYAKR------------------KSTLMQEFA--NCKKT---------- 1075
            |.|........|..|...::|                  ||..:..|:  :|:.:
  Rat   232 HHPTCLFFTFFTQAWPKESQRHLCLLKTSESGFPSTRITKSNALSGFSLQHCRHSIPVFCHPNFY 296

  Fly  1076 -------EDYPMADL--------TCS-NYEC-----------------------------GRVKR 1095
                   |:..:.|:        .|| |..|                             .|:..
  Rat   297 NDTDFLGEELDIVDVKGKESCQKMCSDNVRCQFFTYYPSRGSCSERKGRCYLKLSSNGSPTRILH 361

  Fly  1096 GR------------------HKPSRRIIGGTQASPGNWPFLAAILGGPEKIFYCAGVLISDQWVL 1142
            ||                  .|...|:.||..:..|.||:...:  ...:...|.|.:|.::|:|
  Rat   362 GRGGISGYTLRLCKMDNVCTTKIRPRVFGGAASVHGEWPWQVTL--HTTQGHLCGGSIIGNRWIL 424

  Fly  1143 TASHCVGNYSVIDLEDWTIQL--GVTRRNSFTYSGQKVKVKAVIPHPQYNMAIAHDNDIALFQLA 1205
            ||:||......    ..|:::  |:..::.........:|:.:|.|.||..| ....||||.:|.
  Rat   425 TAAHCFSGTET----PKTLRVYGGIVNQSEINEDTTFFRVQEMIIHDQYTSA-ESGFDIALLKLE 484

  Fly  1206 TRVAFHEHLLPVCLPPPSVRN-LHPGTLCTVIGWGKREDKDP-KSTYEYIVNEVQVPIITRNQCD 1268
            ..:.:.:...|:|||....|| :|  |.|.|.|||..:.:|. :||    :.:.:||:::..:|.
  Rat   485 PAMNYTDFQRPICLPSKGDRNVVH--TECWVTGWGYTKSRDEVQST----LQKAKVPLVSNEECQ 543

  Fly  1269 EWLDNLTVSEGMVCAGFDDGGKDACQGDSGGPLLCPYPGEKNRWFVGGIVSWGIMCAHPRLPGVY 1333
            .......::..::|||:.:||||.|:|||||||.|.:.|.   |.:.||.|||..|.....||||
  Rat   544 TRYRKHKITNKVICAGYKEGGKDTCKGDSGGPLSCKHNGV---WHLVGITSWGEGCGQKERPGVY 605

  Fly  1334 ANVVQYVPWIQEQ 1346
            .||.:||.||.|:
  Rat   606 TNVAKYVDWILEK 618

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Corin	NP_610297.2	CRD_FZ	778..894	CDD:143549	17/67 (25%)
		LDLa	911..942	CDD:238060	11/44 (25%)
		LDLa	945..979	CDD:238060	6/37 (16%)
		SR	980..>1034	CDD:214555	9/67 (13%)
		Tryp_SPc	1104..1346	CDD:238113	80/245 (33%)
F11	NP_001398595.1	APPLE	20..103	CDD:128519	22/96 (23%)
		APPLE	110..193	CDD:128519	23/116 (20%)
		APPLE	200..283	CDD:128519	13/82 (16%)
		APPLE	291..374	CDD:128519	9/82 (11%)
		Tryp_SPc	388..615	CDD:238113	78/242 (32%)