DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Corin and Corin

DIOPT Version :9

Sequence 1:	NP_610297.2	Gene:	Corin / 35691	FlyBaseID:	FBgn0033192	Length:	1397	Species:	Drosophila melanogaster
Sequence 2:	NP_872279.2	Gene:	Corin / 289596	RGDID:	727887	Length:	1111	Species:	Rattus norvegicus

Alignment Length:	614	Identity:	196/614 - (31%)
Similarity:	292/614 - (47%)	Gaps:	80/614 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly   779 CLPIIVRFCQGPQIPYNYTVFPNYIGHFGQLETQTDLDS--YEALVDVRCYELVSLFLCTLFVPK 841
            |.||.:..|.  .:|||.|.:|||:||..|.|.....:|  :.|||...||:.:..|.||:.|||
  Rat   521 CEPITLELCM--NLPYNLTHYPNYLGHRTQKEASISWESALFPALVQTNCYKYLMFFACTILVPK 583

  Fly   842 CG-QSGATVPPCKTLCTETMRRCGFFFDVFGLSLPEYLNCKLFKDFPSSEDCVGL--DEVREVMR 903
            |. .:|..||||:.||..:..||.....:.||..||..:|..|.:..|......|  ::|.|.
  Rat   584 CDVNTGQRVPPCRLLCEHSKERCESVLGIVGLQWPEDTDCSQFPEQSSDNQTCLLPNEDVEEC-- 646

  Fly   904 AATHPK------------CDG--------------------FQCDQNR-CLPQEYVCDGHLDCMD 935
            :.:|.|            |||                    ::|..|: ||....:|||..||.|
  Rat   647 SPSHFKCRSGRCVLGSRRCDGQADCDDDSDEENCGCKERDLWECPLNKQCLKHTLICDGFPDCSD 711

  Fly   936 QADEAKCERCGPDEIYCGDSQCIGTKHICDGIIDCPYGQDERNCLRLSERNGDVGTGVLEVYRIG 1000
            ..||..|..|..||:.|.:.:|:.....|||..||....||..|:.|| :||: .:..|.|:|..
  Rat   712 SMDEKNCSFCQDDELECANHECVPRDLWCDGWTDCSDSSDEWGCVTLS-KNGN-SSSFLTVHRSA 774

  Fly  1001 QRQWMPACVKNWDRAVSPSAVCSILGYSAVNATSVLTQLTHRPLL------ATVNVSTDIWKMYA 1059
            :...:  |...|...:|..| |..:|....:.|.::.....:..|      ..:|.|| :.::..
  Rat   775 RDHHV--CADGWQETLSQLA-CRQMGLGEPSVTELVQGQEGQQWLRLHSSWENLNGST-LQELLV 835

  Fly  1060 KRKSTLMQEFANCKKTEDYPMADLTCSNYECGRVKRGRHKPSRRIIGGTQASPGNWPFLAAILGG 1124
            .|:|        |....:   ..|.|:..:|||  |...:.::||:||..:.||.||:..::...
  Rat   836 HRRS--------CPSGSE---ISLLCTKQDCGR--RPAARMNKRILGGRTSRPGRWPWQCSLQSE 887

  Fly  1125 PEKIFYCAGVLISDQWVLTASHCVGNYSVIDLEDWTIQLGVTRRNSFTYSGQKVKVKAVIPHPQY 1189
            |.. ..|..|||:.:||||.:||.....  |.:.|.:..|:...:..:...|...||.::.||:|
  Rat   888 PSG-HICGCVLIAKKWVLTVAHCFEGRE--DADVWKVVFGINNLDHPSGFMQTRFVKTILLHPRY 949

  Fly  1190 NMAIAHDNDIALFQLATRVAFHEHLLPVCLPPPSVRNLHPGTLCTVIGWGKREDKDPKSTYEYIV 1254
            :.|:. |.||::.:|:..:....::.|||||.|. ..|.|.|.|.:.|||...:|.|     :.:
  Rat   950 SRAVV-DYDISVVELSDDINETSYVRPVCLPSPR-EFLEPDTYCYITGWGHMGNKMP-----FKL 1007

  Fly  1255 NEVQVPIITRNQCDEWLDNLTVSEGMVCAGFDDGGKDACQGDSGGPLLCPYPGEKNRWFVGGIVS 1319
            .|.:|.||...||..:.|..|::..|:|||::.|..|:|.|||||||:|..||  .:|.:.|:.|
  Rat  1008 QEGEVRIIPLEQCQSYFDMKTITNRMICAGYESGTVDSCMGDSGGPLVCERPG--GQWTLFGLTS 1070

  Fly  1320 WGIMCAHPRL-PGVYANVVQYVPWIQEQI 1347
            ||.:|....| ||||:||..:|.||:.||
  Rat  1071 WGSVCFSKVLGPGVYSNVSYFVDWIERQI 1099

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Corin	NP_610297.2	CRD_FZ	778..894	CDD:143549	44/117 (38%)
		LDLa	911..942	CDD:238060	14/51 (27%)
		LDLa	945..979	CDD:238060	12/33 (36%)
		SR	980..>1034	CDD:214555	13/53 (25%)
		SRCR	992..1086	CDD:278931	18/99 (18%)
		Tryp_SPc	1103..1343	CDD:214473	87/240 (36%)
		Tryp_SPc	1104..1346	CDD:238113	88/242 (36%)
Corin	NP_872279.2	DDNN motif	93..96
		CRD_corin_1	200..329	CDD:143554
		LDLa	335..370	CDD:238060
		LDLa	372..406	CDD:238060
		Ldl_recept_a	413..443	CDD:395011
		LDLa	453..480	CDD:238060
		CRD_corin_2	521..641	CDD:143579	45/124 (36%)
		Ldl_recept_a	646..680	CDD:395011	15/66 (23%)
		LDLa	<693..718	CDD:238060	7/24 (29%)
		LDLa	721..755	CDD:238060	9/33 (27%)
		SRCR_2	779..859	CDD:413346	20/85 (24%)
		Tryp_SPc	867..1098	CDD:238113	83/224 (37%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3577
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0007867
OrthoInspector	1	1.000	-	-		oto98208
orthoMCL	1	0.900	-	-		OOG6_107940
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X4386
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	7	6.710