DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Corin and Tmprss15

DIOPT Version :9

Sequence 1:	NP_610297.2	Gene:	Corin / 35691	FlyBaseID:	FBgn0033192	Length:	1397	Species:	Drosophila melanogaster
Sequence 2:	XP_038944148.1	Gene:	Tmprss15 / 288291	RGDID:	1311046	Length:	1028	Species:	Rattus norvegicus

Alignment Length:	675	Identity:	173/675 - (25%)
Similarity:	281/675 - (41%)	Gaps:	186/675 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly   725 FQILINAF--------AL--LAIAGGLAAYFNAYPTIKFVNKTIINTIHVEDTTSFGKNP----A 775
            |:::.|||        ||  :::..|:.:. :.||     ..|::.|...|..|..| .|    .
  Rat   479 FKVVFNAFRNRGCSTIALDDISLTNGICSE-SPYP-----EPTLVPTPPPEHPTDCG-GPFELWE 536

  Fly   776 PGTCLPIIVRFCQGPQIPYNYTVFPNYIGHFGQLETQT-----------DLDSYEALVDVRCYEL 829
            |.|..       ..|..|.||   ||.......|..|:           ||::...:|:||....
  Rat   537 PNTTF-------SSPNFPDNY---PNQAFCIWNLNAQSGKNIQLHFQEFDLENINDVVEVRDGVK 591

  Fly   830 VSLFLCTLFVPKCGQSGATVPPCKTLCTETMRRC------------GF---FFDVFGLSLPEYLN 879
            ....|..::..:        .|.|.|.:.|.|..            ||   |...:.|.:|:
  Rat   592 FDSLLLAVYTGR--------GPVKDLFSTTNRMTVIFDTDMKNGGKGFKANFTSGYYLGIPQ--- 645

  Fly   880 CKLFKDFPSSEDCVGLDEVREVMRAATHPKCDGFQCDQNRCLPQEYVCDGHLDCMDQADEAKCER 944
                   |..:                    |.|||....|:|...:||.:..|.|.:|||.|.|
  Rat   646 -------PCQD--------------------DEFQCKDGNCIPMGNLCDSYQHCSDGSDEAHCVR 683

  Fly   945 CGPDEIYCGDSQCIGTKHICDGIIDCPYGQDERNCLRLSERNGDVGTGVLEVYRIGQRQWMPACV 1009
                  :...:|                           ..||.|...:..:       |..||.
  Rat   684 ------FLNGTQ---------------------------SNNGLVQFNIHNI-------WHIACA 708

  Fly  1010 KNWDRAVSPSAVCSILGYSAVNATSVLTQLTHRPLLAT-----VNVSTDIWKMYAKRKSTLMQEF 1069
            :.|...:| :.||.:||..:.|::        .|:|:|     |.::.      |...|.::...
  Rat   709 EPWTTQIS-NEVCHLLGLGSANSS--------MPILSTGGGPFVRLNE------APNGSLILTPS 758

  Fly  1070 ANCKKTEDYPMADLTCSNYECGRVKRGRHKPSRRIIGGTQASPGNWPFLAAILGGPEKIFY---- 1130
            ..|.:..   :..|.|::..||. |....|...:|:||:....|.||::.|       ::|
  Rat   759 LQCSQDS---LILLQCNHKSCGE-KMVTQKVGPKIVGGSDTQAGAWPWVVA-------LYYRDRS 812

  Fly  1131 -----CAGVLISDQWVLTASHCVGNYSVIDLEDWTIQLGVTRRNSFTYSGQKVK--VKAVIPHPQ 1188
                 |...|:|..|:::|:|||...: :|...||..||:..:::.| |.|.|:  |..::.:|.
  Rat   813 GDRLLCGASLVSSDWLVSAAHCVYRRN-LDPTRWTAVLGLHMQSNLT-SPQVVRRVVDRIVINPH 875

  Fly  1189 YNMAIAHDNDIALFQLATRVAFHEHLLPVCLPPPSVRNLHPGTLCTVIGWGKREDKDPKSTYEYI 1253
            |:.. ...||||:..|..:|.:.:::.|:|||..: :...||.:|::.|||..: .:..||.: :
  Rat   876 YDKR-RKVNDIAMMHLEFKVNYTDYIQPICLPEEN-QTFTPGRMCSIAGWGYNK-INAGSTVD-V 936

  Fly  1254 VNEVQVPIITRNQCDEWLDNLTVSEGMVCAGFDDGGKDACQGDSGGPLLCPYPGEKNRWFVGGIV 1318
            :.|..||:::..:|.:.|....::|.|:|||:::||.|:|||||||||:|.   |.||||:.|:.
  Rat   937 LKEADVPLVSNEKCQQQLPEYDITESMLCAGYEEGGTDSCQGDSGGPLMCQ---ENNRWFLVGVT 998

  Fly  1319 SWGIMCAHPRLPGVYANVVQYVPWI 1343
            |:|:.||.|..|||||.|.|::.||
  Rat   999 SFGVQCALPNHPGVYARVSQFIEWI 1023

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Corin	NP_610297.2	CRD_FZ	778..894	CDD:143549	26/141 (18%)
		LDLa	911..942	CDD:238060	13/30 (43%)
		LDLa	945..979	CDD:238060	1/33 (3%)
		SR	980..>1034	CDD:214555	13/53 (25%)
		SRCR	992..1086	CDD:278931	18/98 (18%)
		Tryp_SPc	1103..1343	CDD:214473	87/250 (35%)
		Tryp_SPc	1104..1346	CDD:238113	89/251 (35%)
Tmprss15	XP_038944148.1	SEA	54..155	CDD:214554
		LDLa	188..221	CDD:238060
		CUB	229..335	CDD:412131
		MAM	351..507	CDD:395504	7/27 (26%)
		CUB	528..635	CDD:395345	25/125 (20%)
		LDLa	647..681	CDD:238060	13/53 (25%)
		Tryp_SPc	789..1025	CDD:238113	89/251 (35%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	2	1.910