DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Corin and Tmprss7

DIOPT Version :9

Sequence 1:	NP_610297.2	Gene:	Corin / 35691	FlyBaseID:	FBgn0033192	Length:	1397	Species:	Drosophila melanogaster
Sequence 2:	NP_001099352.2	Gene:	Tmprss7 / 288118	RGDID:	1304655	Length:	829	Species:	Rattus norvegicus

Alignment Length:	641	Identity:	172/641 - (26%)
Similarity:	246/641 - (38%)	Gaps:	186/641 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly   740 GLAAYFNAYPTIKFVNKTIINTIHVEDTTSF-GKNPAP--GTCLPIIVRFCQGPQIPYNYTVFPN 801
            |:.|||...|..|     ..|||.|::..|| ||..:|  .:..|        |:...|:|.
  Rat   338 GIRAYFEVIPEQK-----CENTILVKEINSFEGKISSPYYPSYYP--------PKCKCNWTF--- 386

  Fly   802 YIGHFGQLETQTDLDSYEALVDVRCYELVSLFLCTLFVPKCGQSGATVPPCKTLCTETMRR--CG 864
                      ||.|.:....:....|.          :.|....|     |:....|....  ||
  Rat   387 ----------QTSLSTLGIALKFHNYS----------ITKKSMKG-----CEHGWWEINEHMYCG 426

  Fly   865 FFFD---VFGLSLP---EYLNCK-------LFKDFPS---SEDCVGLDEVREVMRAATHPKCDGF 913
            .:.|   :|.:..|   ..|.|.       |..::.|   |:.|                ....|
  Rat   427 SYMDHETIFRVPSPLVHIQLQCSSRLSDKPLLVEYGSYNISQPC----------------PAGSF 475

  Fly   914 QCDQNRCLPQEYVCDGHLDCMDQADEAKCERCGPDEIYCGDSQCIGTKH---ICDGIIDCPYGQD 975
            :|....|:||...|||..||.|::||..|....|   .|..|  |..:|   :|||..||..|||
  Rat   476 RCSSGLCVPQAQRCDGVNDCFDESDELFCVTAKP---ACNTS--IFRQHGPLVCDGFQDCEDGQD 535

  Fly   976 ERNCLRLSERNGDVGTGVLEVYRIGQRQWMPACVKNWDRAVSPSAVCSILGYSAVNATSVLTQLT 1040
            |:||.|                                     |..|                 |
  Rat   536 EQNCTR-------------------------------------SIPC-----------------T 546

  Fly  1041 HRPLLATVNVSTDIWKMYAKRKSTLMQEFANCKKTEDYPMADLTCSNYE---CGRVKRGRHKPSR 1102
            :|    |.....||         ...::.|.|....|.|    ..|:.|   |.|.....|
  Rat   547 NR----TFKCGNDI---------CFRKQNAQCDGIVDCP----DRSDEEGCGCSRSSPFLH---- 590

  Fly  1103 RIIGGTQASPGNWPFLAAI--LGGPEKIFYCAGVLISDQWVLTASHCVGNYSVIDLEDWTIQLGV 1165
            |::||:.:..|.||:..::  :|..    :|...:||.:|:|:|:||.....:.|...||..||:
  Rat   591 RVVGGSDSQEGTWPWQVSLHFVGSA----HCGASVISREWLLSAAHCFHGNRLSDPTPWTAHLGM 651

  Fly  1166 TRRNSFTYSGQKVKVKAVIPHPQYNMAIAHDNDIALFQLATRVAFHEHL----LPVCLPPPSVRN 1226
            ..:.:..:..   .|:.::.|..|| :...|.||||.||:  :|:.|.|    .|:|:||...|
  Rat   652 YVQGNAKFVS---PVRRIVVHEYYN-SQTFDYDIALLQLS--IAWPETLRQLIQPICIPPVGQR- 709

  Fly  1227 LHPGTLCTVIGWGKREDKDPKSTYEYIVNEVQVPIITRNQCDEWLDNLTVSEGMVCAGFDDGGKD 1291
            :..|..|.|.|||:|.:.|.|.:  .|:.:.:|.:|.:..|......:|  ..|:|||...|..|
  Rat   710 VRSGEKCWVTGWGRRHEADSKGS--PILQQAEVELIDQTVCVSTYGIIT--SRMLCAGVMSGKSD 770

  Fly  1292 ACQGDSGGPLLCPYPGEKNRWFVGGIVSWGIMCAHPRLPGVYANVVQYVPWIQEQI 1347
            ||:|||||||.|....: .:|.:.||||||..|..|..||||..|..:||||.:.:
  Rat   771 ACKGDSGGPLSCRRKSD-GKWILTGIVSWGYGCGRPNFPGVYTRVSNFVPWIHKYV 825

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Corin	NP_610297.2	CRD_FZ	778..894	CDD:143549	23/133 (17%)
		LDLa	911..942	CDD:238060	13/30 (43%)
		LDLa	945..979	CDD:238060	14/36 (39%)
		SR	980..>1034	CDD:214555	3/53 (6%)
		SRCR	992..1086	CDD:278931	11/93 (12%)
		Tryp_SPc	1103..1343	CDD:214473	85/245 (35%)
		Tryp_SPc	1104..1346	CDD:238113	86/247 (35%)
Tmprss7	NP_001099352.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	30..49
		SEA	94..190	CDD:279699
		CUB	<257..345	CDD:238001	4/6 (67%)
		LDLa	470..504	CDD:238060	14/49 (29%)
		LDLa	545..580	CDD:238060	12/68 (18%)
		Tryp_SPc	591..821	CDD:214473	85/245 (35%)
		Tryp_SPc	592..823	CDD:238113	86/246 (35%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	2	1.910