Protein Alignment Corin and TMPRSS12

DIOPT Version :10

• Sequence 1: NP_610297.2
• Gene: Corin / 35691
• FlyBaseID: FBgn0033192
• Length: 1397
• Species: Drosophila melanogaster
• Sequence 2: NP_872365.2
• Gene: TMPRSS12 / 283471
• HGNCID: 28779
• Length: 348
• Species: Homo sapiens
• Alignment Length: 265
• Identity: 94/265 - (35%)
• Similarity: 139/265 - (52%)
• Gaps: 20/265 - (7%)

  Fly  1089 ECGRVKRGRHKPSRRIIGGTQASPGNWPFLAA--ILGGPEKIFYCAGVLISDQWVLTASHCVGNY 1151
            :||...........||||||:|..|.||::.:  |..|...:..|.|.|:.::|||||:||..:.
Human    63 DCGTAPLKDVLQGSRIIGGTEAQAGAWPWVVSLQIKYGRVLVHVCGGTLVRERWVLTAAHCTKDA 127

  Fly  1152 SVIDLEDWTIQLGVTRRNSFTYSGQKVKVKAVIPHPQYNMAIAHDNDIALFQLATRVAFHEHLLP 1216
            |  |...||..:|....:......:|:|:||:|.||.:.:. ::.||||||.|...|.:::::.|
Human   128 S--DPLMWTAVIGTNNIHGRYPHTKKIKIKAIIIHPNFILE-SYVNDIALFHLKKAVRYNDYIQP 189

  Fly  1217 VCLPPPSVRNLHPGTLCTVIGWGKREDKDPKSTYEYIVNEVQVPIITRNQCDEWLDNLTVSEGMV 1281
            :|||....:.|...|.|.:.|||:.:::...:.   |:.:.:|..|:|..|     |...|.|.:
Human   190 ICLPFDVFQILDGNTKCFISGWGRTKEEGNATN---ILQDAEVHYISREMC-----NSERSYGGI 246

  Fly  1282 ------CAGFDDGGKDACQGDSGGPLLCPYPGEKNRWFVGGIVSWGIMCAHPRLPGVYANVVQYV 1340
                  |||.:||..|.|:|||||||:|..| |..|:||.||.|:|..|.....||||.....|.
Human   247 IPNTSFCAGDEDGAFDTCRGDSGGPLMCYLP-EYKRFFVMGITSYGHGCGRRGFPGVYIGPSFYQ 310

  Fly  1341 PWIQE 1345
            .|:.|
Human   311 KWLTE 315

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Corin	NP_610297.2	CRD_FZ	778..894	CDD:143549
		LDLa	911..942	CDD:238060
		LDLa	945..979	CDD:238060
		SR	980..>1034	CDD:214555
		Tryp_SPc	1104..1346	CDD:238113	91/250 (36%)
TMPRSS12	NP_872365.2	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	24..46
		Tryp_SPc	78..316	CDD:238113	91/250 (36%)