DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Corin and Ssc5d

DIOPT Version :9

Sequence 1:	NP_610297.2	Gene:	Corin / 35691	FlyBaseID:	FBgn0033192	Length:	1397	Species:	Drosophila melanogaster
Sequence 2:	NP_766596.1	Gene:	Ssc5d / 269855	MGIID:	3606211	Length:	1371	Species:	Mus musculus

Alignment Length:	822	Identity:	155/822 - (18%)
Similarity:	241/822 - (29%)	Gaps:	346/822 - (42%)

- Green bases have known domain annotations that are detailed below.

  Fly    69 GSISESSSLSSSNSIVRRHSSHYYPMLEDKQKPSQLPQAATEMLVNMTEQKYCQSAHQGASIAGG 133
            |.::...|.|.::|:              .|||:::|..|.:    .|::...::|.:
Mouse   595 GELTTKPSASLTSSV--------------PQKPTKVPGKAPK----STKKWVTKNARR------- 634

  Fly   134 RQVHHQQQHLVRVDTPVTPPPPIPRRLLRGKSAWQASSPHP------LPLSAGGQDGAHGTGTGT 192
                           |.|.||.:| .....::....:|.||      ||.....:.....|...|
Mouse   635 ---------------PTTQPPGMP-TTKHSRAPGTPTSLHPTARTSELPKRLTTEAPHRQTSHTT 683

  Fly   193 VFVYPQ-----------------PENVTAEAV--------VRGSGDGQGGGGAGLQSALLVDIAT 232
            |.:.|:                 |:.||:||.        :..||:...|   .|:|:  .|.||
Mouse   684 VRLTPRVPWEWTSEPVVSQSTQGPQEVTSEATTTENPQTSLEPSGENTEG---SLESS--QDPAT 743

  Fly   233 RPASGYADADGISDDDRMSLENSVFDESLTSTPVKVAGYLAGRYAGL------------------ 279
            .|.:|            :.:.:..|...|...|.:.||.|...:|||
Mouse   744 TPTAG------------VPVPSGPFRVRLADGPNRCAGRLEVWHAGLWGTVCDDSWDIRDATVAC 796

  Fly   280 --------------SHM-------------AKRAQRSSSSTVDSAYGSSLGGHSERFASSSTSVD 317
                          :|.             .|.::.|.|.....|:|.....|.|....:.|.
Mouse   797 WELGCGKVRPRVGKTHYGPGTGPIWLDDMGCKGSEMSLSDCPSGAWGKHNCDHEEDVVLTCTG-- 859

  Fly   318 FRSRFSSVDTQSSLDEKPLS-------------------------SSIDSPLAR-----DPRDAY 352
                ::..|...|....|.|                         :.:.||..:     |.:..|
Mouse   860 ----YTGDDDYPSWTWDPTSGEDLTKGTTVAARPGHTLSWATTTNTEVPSPATQNLPDTDDQGGY 920

  Fly   353 RERAVLNDAMHKLNNNNTSLGLALY--SASNNNNGSSVA-----SDGSQLPVVPAR----KQPPP 406
            ......          :|..|..|:  :.:....||:|.     |.|...|...||    ::|.|
Mouse   921 ESSWTW----------DTPSGRGLFKGTPTTTKPGSTVTTSTSKSPGHPFPAPRARAGSPRKPTP 975

  Fly   407 VKGSSNSSNSIGETQSQSSKEPSS-----------VSASASTSSAASAGSSTISSGTMS----SM 456
            .:....:|.:.....|.||.|||.           :..|....:::|...|.::.|..|    ::
Mouse   976 ERRPLPTSATTSSPASSSSPEPSGSRQTSGSWPQLIPDSKQEGTSSSPKPSLLTPGLPSPATFAL 1040

  Fly   457 SGPCPAVVP--------------------------------PTDAITKRPGPPEPPLRQ------ 483
            |.|..:::|                                ||..:|  |||...|..:
Mouse  1041 STPNTSLLPTRSPELSGSPTPTSPEGLTSASSMLSEVSRLSPTSELT--PGPDTTPAPEIIPESS 1103

  Fly   484 ------ANVFDPVETGSRGHP---------------PPPLTVRNKLGRNKPPPITYPR--MQQRQ 525
                  .|...|.:..:..||               |.|.|  |......|.|.|.|:  .....
Mouse  1104 DSSDLPMNTRTPTQPFTASHPTSIPQLNTTSYPTIAPQPTT--NPQQPRSPHPATSPQPPTNTHP 1166

  Fly   526 DSTLSSDSYSISSS----------PGYNSKLM--EAP------------LLGSQQGGRKSNAPGS 566
            .||.::.:.|:.||          |..||:|.  |||            .|.|:.|   .::|..
Mouse  1167 SSTPATPTESLPSSRKTELSSPTKPRLNSELTFEEAPSTDASQTQNLELFLASESG---PSSPSP 1228

  Fly   567 AQRQTPLMDLAPTRFLGGAGGGTGSGKQGPAMPPPRSKINFRQDSTISSDSFSQTSSPGYNPKLM 631
            |....||    ||                .|..||||     |....:||..:|..:|.:||.
Mouse  1229 ASNLDPL----PT----------------DAFKPPRS-----QTLHSASDHLTQGPTPNHNPD-- 1266

  Fly   632 EAPLLPSLSAKRLCSAPAPIVCRQGVQHEPIEEL--EPPQTI 671
              |..|       |.:|.|          |:..:  |||..:
Mouse  1267 --PFGP-------CVSPLP----------PVRVMACEPPALV 1289

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Corin	NP_610297.2	CRD_FZ	778..894	CDD:143549
		LDLa	911..942	CDD:238060
		LDLa	945..979	CDD:238060
		SR	980..>1034	CDD:214555
		SRCR	992..1086	CDD:278931
		Tryp_SPc	1103..1343	CDD:214473
		Tryp_SPc	1104..1346	CDD:238113
Ssc5d	NP_766596.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	592..756		40/218 (18%)
		DamX	594..>757	CDD:225805	40/219 (18%)
		SR	758..858	CDD:214555	16/99 (16%)
		SRCR	763..858	CDD:278931	15/94 (16%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	888..1270		85/427 (20%)
		DUF2722	<1011..>1187	CDD:287780	32/179 (18%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1351..1371
		SR	20..119	CDD:214555
		SRCR	25..119	CDD:278931
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	143..200
		SR	199..299	CDD:214555
		SRCR	204..299	CDD:278931
		SR	305..404	CDD:214555
		SRCR	310..404	CDD:278931
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	431..466
		SR	464..565	CDD:214555
		SRCR	469..565	CDD:278931
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	0	0.000