DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Corin and Tmprss5

DIOPT Version :9

Sequence 1:	NP_610297.2	Gene:	Corin / 35691	FlyBaseID:	FBgn0033192	Length:	1397	Species:	Drosophila melanogaster
Sequence 2:	NP_695223.2	Gene:	Tmprss5 / 266681	RGDID:	628625	Length:	445	Species:	Rattus norvegicus

Alignment Length:	402	Identity:	126/402 - (31%)
Similarity:	196/402 - (48%)	Gaps:	62/402 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly   968 IDCPYGQDERNCL-----RLSER-NGDVGTGVLEVYRIGQRQWMPACVKNWDRAVSPSAVCSILG 1026
            :.||....|...|     .:|.| ||:  ..:|||....:..|:..|.:.|:.|:. ..:|..||
  Rat    81 LSCPGVSSEEKLLPSLPKAVSFRINGE--DLLLEVQVRARPDWLLVCHEGWNPALG-MHICQSLG 142

  Fly  1027 Y------SAVNATSV-------LTQLTHRPLLATVNVSTDIWKMYAKRKSTLMQEFANCKKTEDY 1078
            |      .|||.:.:       ..||:.||    .::..:.|           |...||....
  Rat   143 YFRLTQHKAVNLSDIKLNRSQEFAQLSARP----GSLVEEAW-----------QPSTNCPSGR-- 190

  Fly  1079 PMADLTCSNYECGRVKRGRHKP-SRRIIGGTQASPGNWPFLAAILGGPEKIFYCAGVLISDQWVL 1142
             :..|.||  |||.      :| :.||:||...:.|.||:.|:::.|....  |...:::..||:
  Rat   191 -IVSLKCS--ECGA------RPLASRIVGGQAVASGRWPWQASVMLGSRHT--CGASVLAPYWVV 244

  Fly  1143 TASHCVGNYSVIDLEDWTIQLGVTRRNSFTYSGQKVKVKAVIPHPQYNMAIAHDNDIALFQLATR 1207
            ||:||:.::.:..|..|.:..|:. .:|.....|...|:.:||||.|: |..||.|:||.||.|.
  Rat   245 TAAHCMYSFRLSRLSSWRVHAGLV-SHSAVRQHQGTMVEKIIPHPLYS-AQNHDYDVALLQLRTP 307

  Fly  1208 VAFHEHLLPVCLPPPSVRNLHPGTLCTVIGWGKREDKDPKSTYEY-IVNEVQVPIITRNQCD-EW 1270
            :.|.:.:..||||... ::...|:.|.|.|||   ..||..|:.. .:.:..||:::.:.|: ..
  Rat   308 INFSDTVSAVCLPAKE-QHFPQGSQCWVSGWG---HTDPSHTHSSDTLQDTMVPLLSTDLCNSSC 368

  Fly  1271 LDNLTVSEGMVCAGFDDGGKDACQGDSGGPLLCPYPGEKNRWFVGGIVSWGIMCAHPRLPGVYAN 1335
            :.:..::..|:|||:.||..|||||||||||:||   ..:.|.:.|:||||..||.|..|||||.
  Rat   369 MYSGALTHRMLCAGYLDGRADACQGDSGGPLVCP---SGDTWHLVGVVSWGRGCAEPNRPGVYAK 430

  Fly  1336 VVQYVPWIQEQI 1347
            |.:::.||.:.:
  Rat   431 VAEFLDWIHDTV 442

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Corin	NP_610297.2	CRD_FZ	778..894	CDD:143549
		LDLa	911..942	CDD:238060
		LDLa	945..979	CDD:238060	3/10 (30%)
		SR	980..>1034	CDD:214555	19/65 (29%)
		SRCR	992..1086	CDD:278931	23/106 (22%)
		Tryp_SPc	1103..1343	CDD:214473	87/241 (36%)
		Tryp_SPc	1104..1346	CDD:238113	88/243 (36%)
Tmprss5	NP_695223.2	SRCR_2	106..203	CDD:406055	29/125 (23%)
Tmprss5	NP_695223.2	Tryp_SPc	208..441	CDD:238113	88/243 (36%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910