DRSC/TRiP Functional Genomics Resources

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Protein Alignment Corin and Fzd9

DIOPT Version :9

Sequence 1:NP_610297.2 Gene:Corin / 35691 FlyBaseID:FBgn0033192 Length:1397 Species:Drosophila melanogaster
Sequence 2:NP_695217.1 Gene:Fzd9 / 266608 RGDID:628817 Length:592 Species:Rattus norvegicus


Alignment Length:304 Identity:71/304 - (23%)
Similarity:104/304 - (34%) Gaps:97/304 - (31%)


- Green bases have known domain annotations that are detailed below.


  Fly   771 GKNPAPGTCLPIIVRFCQGPQIPYNYTVFPNYIGHFGQLETQTDLDSYEALVDVRCYELVSLFLC 835
            |:.|||  |..:.:..|:|  |.||.|..||.:||..|.|....|..:..||...|:..:..|||
  Rat    34 GRGPAP--CQAMEIPMCRG--IGYNLTRMPNLLGHTSQGEAAAQLAEFSPLVQYGCHSHLRFFLC 94

  Fly   836 TLFVPKC-GQSGATVPPCKTLCTETMRRCGFFFDVFGLSLPEYLNCKLFKDFPSSEDCVGLDEVR 899
            :|:.|.| .|....:|.|:.:|.:...||....:.|....|:.|:|..                 
  Rat    95 SLYAPMCTDQVSTPIPACRPMCEQARLRCAPIMEQFNFGWPDSLDCAR----------------- 142

  Fly   900 EVMRAATHPKCDGFQCDQNRCLPQEYVCDGHLDCMDQADEAKCERCGPDEIYCG----------- 953
                                 ||...  |.|..||:..:.|   ..||.|.:.|           
  Rat   143 ---------------------LPTRN--DPHALCMEAPENA---TAGPTEPHKGLGMLPVAPRPA 181

  Fly   954 -----DSQCIGTKHICDGIIDCPYGQDERNCLRLSERNGDVGTGVLEVYRIGQRQWMPACVKNWD 1013
                 .:...|:...||......|.:..|:|   :.|   .|.|| ||:              |.
  Rat   182 RPPGDSAPGPGSGGTCDNPEKFQYVEKSRSC---APR---CGPGV-EVF--------------WS 225

  Fly  1014 RAVSPSAVCSILGYSAV----NATSVLT--------QLTHRPLL 1045
            |.....|:..:..:||:    .|.:|.|        |...||::
  Rat   226 RRDKDFALVWMAVWSALCFFSTAFTVFTFLLEPHRFQYPERPII 269

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
CorinNP_610297.2 CRD_FZ 778..894 CDD:143549 33/116 (28%)
LDLa 911..942 CDD:238060 7/30 (23%)
LDLa 945..979 CDD:238060 9/49 (18%)
SR 980..>1034 CDD:214555 12/57 (21%)
SRCR 992..1086 CDD:278931 15/66 (23%)
Tryp_SPc 1103..1343 CDD:214473
Tryp_SPc 1104..1346 CDD:238113
Fzd9NP_695217.1 CRD_FZ9 36..162 CDD:143572 43/172 (25%)
Required for Wnt-activated receptor activity. /evidence=ECO:0000269|PubMed:12138115 59..173 37/156 (24%)
7tmF_FZD9 222..543 CDD:320164 12/62 (19%)
TM helix 1 232..256 CDD:320164 6/23 (26%)
TM helix 2 265..286 CDD:320164 2/5 (40%)
TM helix 3 315..337 CDD:320164
TM helix 4 358..374 CDD:320164
TM helix 5 396..419 CDD:320164
TM helix 6 450..472 CDD:320164
TM helix 7 504..529 CDD:320164
Lys-Thr-X-X-X-Trp motif, mediates interaction with the PDZ domain of Dvl family members. /evidence=ECO:0000250 533..538
Required for CTNNB1 accumulation and TCF transcription factor activity. /evidence=ECO:0000269|PubMed:12138115 555..592
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_KOG3577
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 1 1.000 - -
TreeFam 00.000 Not matched by this tool.
21.900

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