Protein Alignment Corin and Fzd9

DIOPT Version :10

• Sequence 1: NP_610297.2
• Gene: Corin / 35691
• FlyBaseID: FBgn0033192
• Length: 1397
• Species: Drosophila melanogaster
• Sequence 2: NP_695217.1
• Gene: Fzd9 / 266608
• RGDID: 628817
• Length: 592
• Species: Rattus norvegicus
• Alignment Length: 304
• Identity: 71/304 - (23%)
• Similarity: 104/304 - (34%)
• Gaps: 97/304 - (31%)

  Fly   771 GKNPAPGTCLPIIVRFCQGPQIPYNYTVFPNYIGHFGQLETQTDLDSYEALVDVRCYELVSLFLC 835
            |:.|||  |..:.:..|:|  |.||.|..||.:||..|.|....|..:..||...|:..:..|||
  Rat    34 GRGPAP--CQAMEIPMCRG--IGYNLTRMPNLLGHTSQGEAAAQLAEFSPLVQYGCHSHLRFFLC 94

  Fly   836 TLFVPKC-GQSGATVPPCKTLCTETMRRCGFFFDVFGLSLPEYLNCKLFKDFPSSEDCVGLDEVR 899
            :|:.|.| .|....:|.|:.:|.:...||....:.|....|:.|:|..
  Rat    95 SLYAPMCTDQVSTPIPACRPMCEQARLRCAPIMEQFNFGWPDSLDCAR----------------- 142

  Fly   900 EVMRAATHPKCDGFQCDQNRCLPQEYVCDGHLDCMDQADEAKCERCGPDEIYCG----------- 953
                                 ||...  |.|..||:..:.|   ..||.|.:.|
  Rat   143 ---------------------LPTRN--DPHALCMEAPENA---TAGPTEPHKGLGMLPVAPRPA 181

  Fly   954 -----DSQCIGTKHICDGIIDCPYGQDERNCLRLSERNGDVGTGVLEVYRIGQRQWMPACVKNWD 1013
                 .:...|:...||......|.:..|:|   :.|   .|.|| ||:              |.
  Rat   182 RPPGDSAPGPGSGGTCDNPEKFQYVEKSRSC---APR---CGPGV-EVF--------------WS 225

  Fly  1014 RAVSPSAVCSILGYSAV----NATSVLT--------QLTHRPLL 1045
            |.....|:..:..:||:    .|.:|.|        |...||::
  Rat   226 RRDKDFALVWMAVWSALCFFSTAFTVFTFLLEPHRFQYPERPII 269

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Corin	NP_610297.2	CRD_FZ	778..894	CDD:143549	33/116 (28%)
		LDLa	911..942	CDD:238060	7/30 (23%)
		LDLa	945..979	CDD:238060	9/49 (18%)
		SR	980..>1034	CDD:214555	12/57 (21%)
		Tryp_SPc	1104..1346	CDD:238113
Fzd9	NP_695217.1	CRD_FZ9	36..162	CDD:143572	43/172 (25%)
		Required for Wnt-activated receptor activity. /evidence=ECO:0000269|PubMed:12138115	59..173		37/156 (24%)
		7tmF_FZD9	222..543	CDD:320164	12/62 (19%)
		TM helix 1	231..256	CDD:320164	6/24 (25%)
		TM helix 2	265..286	CDD:320164	2/5 (40%)
		TM helix 3	315..341	CDD:320164
		TM helix 4	358..374	CDD:320164
		TM helix 5	396..426	CDD:320164
		TM helix 6	445..472	CDD:320164
		TM helix 7	504..529	CDD:320164
		Lys-Thr-X-X-X-Trp motif, mediates interaction with the PDZ domain of Dvl family members. /evidence=ECO:0000250	533..538
		Required for CTNNB1 accumulation and TCF transcription factor activity. /evidence=ECO:0000269|PubMed:12138115	555..592