DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Corin and Smo

DIOPT Version :9

Sequence 1:NP_610297.2 Gene:Corin / 35691 FlyBaseID:FBgn0033192 Length:1397 Species:Drosophila melanogaster
Sequence 2:NP_036939.1 Gene:Smo / 25273 RGDID:3726 Length:793 Species:Rattus norvegicus


Alignment Length:160 Identity:42/160 - (26%)
Similarity:63/160 - (39%) Gaps:30/160 - (18%)


- Green bases have known domain annotations that are detailed below.


  Fly   779 CLPIIVRFCQGPQIPYNYTVFPNYIGHFGQLETQTDLDSYEALVDV-RCYELVSLFLCTLFVPKC 842
            |.|:....|.|..:||..|..........|.|..:.|..:..|.:. ||:.::...||.:::|||
  Rat    74 CEPLRYNVCLGSALPYGATTTLLAGDSDSQEEAHSKLVLWSGLRNAPRCWAVIQPLLCAVYMPKC 138

  Fly   843 GQSGATVPPCKTLCTETMRRCGFFFDVFGLSLPEYLNCKLFKDFPSSEDCVGLDEVREV------ 901
             ::.....|.:|||..|...|.......|  .|::|.|.. ..||  |.|.  :||:.:      
  Rat   139 -ENDRVELPSRTLCQATRGPCAIVERERG--WPDFLRCTP-DHFP--EGCP--NEVQNIKFNSSG 195

  Fly   902 -----MRAATHPK--------CDGFQCDQN 918
                 :....:||        | |.|| ||
  Rat   196 QCEAPLVRTDNPKSWYEDVEGC-GIQC-QN 223

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
CorinNP_610297.2 CRD_FZ 778..894 CDD:143549 32/115 (28%)
LDLa 911..942 CDD:238060 5/8 (63%)
LDLa 945..979 CDD:238060
SR 980..>1034 CDD:214555
SRCR 992..1086 CDD:278931
Tryp_SPc 1103..1343 CDD:214473
Tryp_SPc 1104..1346 CDD:238113
SmoNP_036939.1 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 35..61
CRD_SMO 70..200 CDD:143560 34/133 (26%)
Frizzled 225..554 CDD:279827
Interaction with BBS5 and BBS7. /evidence=ECO:0000250|UniProtKB:P56726 542..573
Interaction with DLG5. /evidence=ECO:0000250|UniProtKB:P56726 585..597
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 674..702
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_KOG3577
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
10.900

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