Protein Alignment Corin and Proc

DIOPT Version :10

• Sequence 1: NP_610297.2
• Gene: Corin / 35691
• FlyBaseID: FBgn0033192
• Length: 1397
• Species: Drosophila melanogaster
• Sequence 2: XP_008770240.3
• Gene: Proc / 25268
• RGDID: 3411
• Length: 500
• Species: Rattus norvegicus
• Alignment Length: 567
• Identity: 151/567 - (26%)
• Similarity: 222/567 - (39%)
• Gaps: 150/567 - (26%)

  Fly   832 LFLCTLFVPKCGQSGATVPPCKTLCTE-------TMRRCGFFF-DVFGLSLPEYLNCKLFKDFPS 888
            :||  ||....|.||.:..|.....:.       .:||...|. :|...||..  .|
  Rat    45 IFL--LFASTWGISGVSAHPDPVFSSSEGAHQVLRVRRANSFLEEVRAGSLER--EC-------- 97

  Fly   889 SEDCVGLDEVREVMRAATHPKC------DGFQCDQNRCLPQEYVCDGHLDCMDQADEAKCERCGP 947
            .|:....:|.:|:.:.......      ||.||...   |.::.||           :.|
  Rat    98 MEEICDFEEAQEIFQNVEDTLAFWIKYFDGDQCSTP---PLDHQCD-----------SPC----- 143

  Fly   948 DEIYCGDSQCIGTKHICDGI----IDCPYGQDERNCLR------LSERNGDVGTGVLEVYRIGQR 1002
                ||...||      ||:    ..|..|.:.|.|.:      ...:||......||..| |:|
  Rat   144 ----CGHGTCI------DGLGGFSCSCDKGWEGRFCQQEMGFQDCRVKNGGCYHYCLEETR-GRR 197

  Fly  1003 QWMPACVKNWDRAVSPSAVCSILGYSAVNATSVLTQLTHRPLLATVNVST-DIWKMYAKRKSTLM 1066
                 |      |.:|       ||...:        .|.....|||... .:||...|::.
  Rat   198 -----C------ACAP-------GYELAD--------DHMHCRPTVNFPCGKLWKRTDKKRK--- 233

  Fly  1067 QEFANCKKTEDYPMADLTCSNYECGRVKRGRHKPSRRIIGGTQASPGNWPFLAAILGGPEKIFYC 1131
                |.|:..|....:|     |.|          .||:.||....|:.|:.|.:|...:|: .|
  Rat   234 ----NFKRDIDPEDEEL-----ELG----------PRIVNGTLTKQGDSPWQAILLDSKKKL-AC 278

  Fly  1132 AGVLISDQWVLTASHC----------VGNYSVIDLEDWTIQLGVTRRNSFTYSGQKVKVKAVIPH 1186
            .||||...|||||:||          :|.|.:...:.|.:.|               .:|.|:.|
  Rat   279 GGVLIHTSWVLTAAHCLESSKKLTVRLGEYDLRRRDPWELDL---------------DIKEVLVH 328

  Fly  1187 PQYNMAIAHDNDIALFQLATRVAFHEHLLPVCLPPPSVRN--LHPGTLCTVIGWGKRED--KDPK 1247
            |.|..:.: ||||||.:|:......:.::|:|||...:..  ...|....|.|||.:.|  ||.:
  Rat   329 PNYTRSNS-DNDIALLRLSQPATLSKTIVPICLPNSGLAQELSQAGQETVVTGWGYQSDKVKDGR 392

  Fly  1248 STYEYIVNEVQVPIITRNQCDEWLDNLTVSEGMVCAGFDDGGKDACQGDSGGPLLCPYPGEKNRW 1312
            ....:|:..:::|:..||.|.:.::|: |||.|:|||.....:|||.||||||::..:.|   .|
  Rat   393 RNRTFILTFIRIPLAARNDCMQVMNNV-VSENMLCAGIIGDTRDACDGDSGGPMVVFFRG---TW 453

  Fly  1313 FVGGIVSWGIMCAHPRLPGVYANVVQYVPWIQEQIAKHSRPIKEDRV 1359
            |:.|:||||..|.|....|||..|..|:.||...|.:....:|..::
  Rat   454 FLVGLVSWGEGCGHLNNYGVYTKVGSYLKWIHSYIGERDVSLKSPKL 500

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Corin	NP_610297.2	CRD_FZ	778..894	CDD:143549	16/69 (23%)
		LDLa	911..942	CDD:238060	7/30 (23%)
		LDLa	945..979	CDD:238060	9/37 (24%)
		SR	980..>1034	CDD:214555	12/59 (20%)
		Tryp_SPc	1104..1346	CDD:238113	87/255 (34%)
Proc	XP_008770240.3	GLA	65..125	CDD:214503	10/69 (14%)
		EGF_CA	126..170	CDD:238011	17/72 (24%)
		FXa_inhibition	178..213	CDD:464251	13/61 (21%)
		Tryp_SPc	252..486	CDD:238113	87/254 (34%)