Protein Alignment Corin and F9

DIOPT Version :10

• Sequence 1: NP_610297.2
• Gene: Corin / 35691
• FlyBaseID: FBgn0033192
• Length: 1397
• Species: Drosophila melanogaster
• Sequence 2: NP_113728.1
• Gene: F9 / 24946
• RGDID: 2589
• Length: 462
• Species: Rattus norvegicus
• Alignment Length: 545
• Identity: 142/545 - (26%)
• Similarity: 219/545 - (40%)
• Gaps: 156/545 - (28%)

  Fly   855 LCTETMRRCGFFFDVFG----LSLPEYLNCKLFKDFPS---SEDCV----GLDEVREVMRAATHP 908
            |.||    |..|.|...    |:.|:..|....::|..   ..:|:    ..:|.|||.......
  Rat    17 LSTE----CAVFLDRENATKILTRPKRYNSGKLEEFVQGNLERECIEERCSFEEAREVFENTEKT 77

  Fly   909 K------CDGFQCDQNRCLPQEYVCDGHLDCMDQADEAKCERCGPDEIYCGDSQCIGTKHICDGI 967
            .      .||.||:.|.||      :|.: |.|..:..:|.
  Rat    78 TEFWKQYVDGDQCESNPCL------NGGI-CKDDINSYECW------------------------ 111

  Fly   968 IDCPYGQDERNC---LRLSERNG------------DVGTGVLEVYRIGQRQWMPACVKNWDRAVS 1017
              |..|.:.|||   ...|.:||            .:.....|.|::.:.|      |:.:.||.
  Rat   112 --CQAGFEGRNCELDATCSIKNGRCKQFCKNSPDNKIICSCTEGYQLAEDQ------KSCEPAVP 168

  Fly  1018 -PSAVCSILGYSAVNATSVLTQLTHRPLLATVNVSTDIWKMYAKRKSTLMQEFANC----KKTED 1077
             |....|: .|::...|..          .||..:||    |......::.:..|.    ..||:
  Rat   169 FPCGRVSV-AYNSKKITRA----------ETVFSNTD----YGNSTELILDDITNSTILDNLTEN 218

  Fly  1078 -YPMADLTCSNYECGRVKRGRHKPSRRIIGGTQASPGNWPFLAAILGGPEKIFYCAGVLISDQWV 1141
             .|:.|.|                  |::||..|.||..|: ..||.|..:.| |.|.:|:::|:
  Rat   219 SEPINDFT------------------RVVGGENAKPGQIPW-QVILNGEIEAF-CGGAIINEKWI 263

  Fly  1142 LTASHCV----------GNYSVIDLEDWTIQLGVTRRNSFTYSGQKVKVKAVIPHPQYNMAI-AH 1195
            :||:||:          |.:::.:.|| |.|    |||          |...|||.|||..| .:
  Rat   264 VTAAHCLKPGDKIEVVAGEHNIDEKED-TEQ----RRN----------VIRTIPHHQYNATINKY 313

  Fly  1196 DNDIALFQLATRVAFHEHLLPVCLPPPSVRNLH----PGTLCTVIGWGKREDKDPKSTYEYIVNE 1256
            .:||||.:|...:..:.::.|:|:......|:.    .|   .|.||||..:|..:::   |:..
  Rat   314 SHDIALLELDKPLILNSYVTPICVANKEYTNIFLKFGSG---YVSGWGKVFNKGRQAS---ILQY 372

  Fly  1257 VQVPIITRNQCDEWLDNLTVSEGMVCAGFDDGGKDACQGDSGGPLLCPYPGEKNRWFVGGIVSWG 1321
            ::||::.|..|.. ....::...|.|||:.:||||:|:||||||.:....|..   |:.||:|||
  Rat   373 LRVPLVDRATCLR-STKFSIYNNMFCAGYREGGKDSCEGDSGGPHVTEVEGTS---FLTGIISWG 433

  Fly  1322 IMCAHPRLPGVYANVVQYVPWIQEQ 1346
            ..||.....|:|..|.:||.||:|:
  Rat   434 EECAMKGKYGIYTKVSRYVNWIKEK 458

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Corin	NP_610297.2	CRD_FZ	778..894	CDD:143549	11/49 (22%)
		LDLa	911..942	CDD:238060	10/30 (33%)
		LDLa	945..979	CDD:238060	3/33 (9%)
		SR	980..>1034	CDD:214555	12/66 (18%)
		Tryp_SPc	1104..1346	CDD:238113	85/256 (33%)
F9	NP_113728.1	GLA	21..85	CDD:214503	12/63 (19%)
		EGF_CA	86..122	CDD:238011	15/68 (22%)
		FXa_inhibition	127..163	CDD:464251	7/41 (17%)
		Tryp_SPc	228..458	CDD:238113	85/256 (33%)