Protein Alignment Corin and Habp2

DIOPT Version :10

• Sequence 1: NP_610297.2
• Gene: Corin / 35691
• FlyBaseID: FBgn0033192
• Length: 1397
• Species: Drosophila melanogaster
• Sequence 2: NP_001316864.1
• Gene: Habp2 / 226243
• MGIID: 1196378
• Length: 554
• Species: Mus musculus
• Alignment Length: 580
• Identity: 150/580 - (25%)
• Similarity: 214/580 - (36%)
• Gaps: 155/580 - (26%)

  Fly   869 VFGLSL--------PEYLNCKLFKDFPSSEDCVGLDEVREVMRAATHPKCDGFQCDQNRCLPQEY 925
            |.||||        |::.....:..:..|..    ||...|.: .|....|.:..|.:.|  |..
Mouse    17 VIGLSLMSFIAPPDPDWTPDDYYYSYEQSSP----DEDPSVTQ-TTPENPDWYYEDDDPC--QSN 74

  Fly   926 VCDGHLDCMDQADEAKC--------ERCGPDEIYCGDSQCIGTKHICDGIIDC------------ 970
            .|:...||:.:.|...|        .||...:..|.|:.|:..        ||
Mouse    75 PCEHGGDCIIRGDTFSCSCPAPFSGSRCQTAQNKCKDNPCVHG--------DCLITQKHPYYRCA 131

  Fly   971 ---PY-GQDERNCLRLSERNGDVGTGVLEVYRIGQRQWMPACVKNWDRAVSPSAVCSI------- 1024
               || |.|....|.....|.....||...:|...| :..||...:     ....|.|
Mouse   132 CKYPYTGPDCSKVLPACRPNPCQNGGVCSRHRRRSR-FTCACPDQY-----KGKFCEIGPDDCYV 190

  Fly  1025 -LGYS-------AVNATSVLTQLTHRPLLATVNVSTDIWKMYAKRKSTL-MQEFANCKKTE---- 1076
             .|||       .||....|...:|..|..|.|       |:.:...|. :.|...|:..:
Mouse   191 GDGYSYRGKVSKTVNQNPCLYWNSHLLLQETYN-------MFMEDAETHGIAEHNFCRNPDGDHK 248

  Fly  1077 --------------DY------PMAD------------LTCSNYE-CGRVKRGRHKPSRRIIGGT 1108
                          :|      |:.|            :....:| ||:.:...| ..:||.||.
Mouse   249 PWCFVKVNSEKVKWEYCDVTVCPVPDTPNPVESLLEPVMELPGFESCGKTEVAEH-AVKRIYGGF 312

  Fly  1109 QASPGNWPF-------LAAILGGPEKIFYCAGVLISDQWVLTASHCVGNYSVIDLEDWTIQLGVT 1166
            :::.|..|:       |......|:..| |.|.||...|||||:||..    |:.:...:.||..
Mouse   313 KSTAGKHPWQVSLQTSLPLTTSMPQGHF-CGGALIHPCWVLTAAHCTD----INTKHLKVVLGDQ 372

  Fly  1167 RRNSFTYSGQKVKVKAVIPHPQYNM--AIAHDNDIALFQLATRVAFH-----EHLLPVCLPP--- 1221
            .........|..:|:.::.:.|||.  .|.| |||||.:|.. |..|     .::..||||.
Mouse   373 DLKKTESHEQTFRVEKILKYSQYNERDEIPH-NDIALLKLKP-VGGHCALESRYVKTVCLPSDPF 435

  Fly  1222 PSVRNLHPGTLCTVIGWGKREDKDPKSTYEYIVNEVQVPIITRNQCD-EWLDNLTVSEGMVCAG- 1284
            ||      ||.|.:.|||..|..:....    :.:.:|.:|....|: ..|.:.|:.:.|:|||
Mouse   436 PS------GTECHISGWGVTETGEGSRQ----LLDAKVKLIANPLCNSRQLYDHTIDDSMICAGN 490

  Fly  1285 FDDGGKDACQGDSGGPLLCPYPGEKNRWFVGGIVSWGIMCAHPRLPGVYANVVQYVPWIQ 1344
            ....|.|.|||||||||.|...|   .::|.||||||..|.  :.||||..|.:::.||:
Mouse   491 LQKPGSDTCQGDSGGPLTCEKDG---TYYVYGIVSWGQECG--KKPGVYTQVTKFLNWIK 545

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Corin	NP_610297.2	CRD_FZ	778..894	CDD:143549	7/32 (22%)
		LDLa	911..942	CDD:238060	8/30 (27%)
		LDLa	945..979	CDD:238060	10/49 (20%)
		SR	980..>1034	CDD:214555	15/68 (22%)
		Tryp_SPc	1104..1346	CDD:238113	87/260 (33%)
Habp2	NP_001316864.1	EGF_CA	67..103	CDD:238011	9/37 (24%)
		EGF_CA	150..182	CDD:238011	7/37 (19%)
		KR	187..271	CDD:238056	15/90 (17%)
		Tryp_SPc	308..547	CDD:238113	87/260 (33%)