DRSC/TRiP Functional Genomics Resources

powered by:
logo

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Corin and F12

DIOPT Version :10

Sequence 1:NP_610297.2 Gene:Corin / 35691 FlyBaseID:FBgn0033192 Length:1397 Species:Drosophila melanogaster
Sequence 2:NP_000496.2 Gene:F12 / 2161 HGNCID:3530 Length:615 Species:Homo sapiens


Alignment Length:605 Identity:157/605 - (25%)
Similarity:232/605 - (38%) Gaps:153/605 - (25%)


- Green bases have known domain annotations that are detailed below.


  Fly   841 KCGQSGATVPPCKTLCTETM-----RRCGFFFDVFGLSLPEYLNCKLFKDFPSSE--DCVGLDEV 898
            ||...|...|  :..|..|.     :|.|:..:      |:.:.....|..|..:  .||.    
Human    60 KCTHKGRPGP--QPWCATTPNFDQDQRWGYCLE------PKKVKDHCSKHSPCQKGGTCVN---- 112

  Fly   899 REVMRAATHPKC----DGFQCDQNRCLPQEYVCDGHLDCM----DQADEAKCERCGPDEIYCG-- 953
               |.:..|..|    .|..|.:.:|...:.:...|.:.:    :||..|:|:..||| .:|.  
Human   113 ---MPSGPHCLCPQHLTGNHCQKEKCFEPQLLRFFHKNEIWYRTEQAAVARCQCKGPD-AHCQRL 173

  Fly   954 DSQCIGTKHICDG----------IIDCPYGQDERNCLRLSERNGDVGT-------------GVLE 995
            .||...|.....|          :..||.|.....|        ||.|             |:..
Human   174 ASQACRTNPCLHGGRCLEVEGHRLCHCPVGYTGAFC--------DVDTKASCYDGRGLSYRGLAR 230

  Fly   996 VYRIGQ--RQWMPAC---------VKNW-----------DRAVSPSAVCSILG------------ 1026
            ....|.  :.|....         .:||           |..:.|  .|.:|.            
Human   231 TTLSGAPCQPWASEATYRNVTAEQARNWGLGGHAFCRNPDNDIRP--WCFVLNRDRLSWEYCDLA 293

  Fly  1027 -----YSAVNATSVLTQLTHRPLL-------------ATVNVSTDIWKMYAKRKSTLMQEFANCK 1073
                 ..|...|.|..:| |.||:             .|...|.....:.|||:..       ..
Human   294 QCQTPTQAAPPTPVSPRL-HVPLMPAQPAPPKPQPTTRTPPQSQTPGALPAKREQP-------PS 350

  Fly  1074 KTEDYPMADLTCSNYECGRVKRGRHKPSRRIIGGTQASPGNWPFLAAILGGPEKIFYCAGVLISD 1138
            .|.:.|::        ||:..|.......|::||..|..|..|::||:..|..   :|||.||:.
Human   351 LTRNGPLS--------CGQRLRKSLSSMTRVVGGLVALRGAHPYIAALYWGHS---FCAGSLIAP 404

  Fly  1139 QWVLTASHCVGNYSVIDLEDWTIQLGVTRRNSFTYSGQKVKVKAVIPHPQYNMAIAHDNDIALFQ 1203
            .|||||:||:.:...  .||.|:.||..|||......|.:.|::...|..:: .:::.:|:||.:
Human   405 CWVLTAAHCLQDRPA--PEDLTVVLGQERRNHSCEPCQTLAVRSYRLHEAFS-PVSYQHDLALLR 466

  Fly  1204 L-----ATRVAFHEHLLPVCLPPPSVRNLHPG--TLCTVIGWGKREDKDPKSTYEYIVNEVQVPI 1261
            |     .:......::.|||||..:.|   |.  |||.|.|||  ...:....|...:.|.|||.
Human   467 LQEDADGSCALLSPYVQPVCLPSGAAR---PSETTLCQVAGWG--HQFEGAEEYASFLQEAQVPF 526

  Fly  1262 ITRNQCD-EWLDNLTVSEGMVCAGFDDGGKDACQGDSGGPLLCPYPGEKNRWFVGGIVSWGIMCA 1325
            ::..:|. ..:...::..||:||||.:||.|||||||||||:|.....:.|..:.||:|||..|.
Human   527 LSLERCSAPDVHGSSILPGMLCAGFLEGGTDACQGDSGGPLVCEDQAAERRLTLQGIISWGSGCG 591

  Fly  1326 HPRLPGVYANVVQYVPWIQE 1345
            ....||||.:|..|:.||:|
Human   592 DRNKPGVYTDVAYYLAWIRE 611

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
CorinNP_610297.2 CRD_FZ 778..894 CDD:143549 12/59 (20%)
LDLa 911..942 CDD:238060 7/34 (21%)
LDLa 945..979 CDD:238060 11/45 (24%)
SR 980..>1034 CDD:214555 13/105 (12%)
Tryp_SPc 1104..1346 CDD:238113 91/250 (36%)
F12NP_000496.2 FN2 41..88 CDD:128373 8/29 (28%)
EGF_CA 96..131 CDD:238011 8/41 (20%)
FN1 133..173 CDD:238018 10/40 (25%)
EGF 178..206 CDD:394967 5/27 (19%)
Kringle 217..295 CDD:395005 9/79 (11%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 298..359 14/76 (18%)
Tryp_SPc 373..612 CDD:238113 91/250 (36%)

Return to query results.
Submit another query.