Protein Alignment Corin and F11

DIOPT Version :10

• Sequence 1: NP_610297.2
• Gene: Corin / 35691
• FlyBaseID: FBgn0033192
• Length: 1397
• Species: Drosophila melanogaster
• Sequence 2: XP_005262878.1
• Gene: F11 / 2160
• HGNCID: 3529
• Length: 626
• Species: Homo sapiens
• Alignment Length: 700
• Identity: 165/700 - (23%)
• Similarity: 251/700 - (35%)
• Gaps: 230/700 - (32%)

  Fly   798 VFPNYIGHF-------GQLETQTDLDSYEALVDVRCYELVSLFLCTLFVPKCGQSGATVPPCKTL 855
            :|...:.||       |:..||        |:...|:|  ...:.|:|.|       :...|:.:
Human     2 IFLYQVVHFILFTSVSGECVTQ--------LLKDTCFE--GGDITTVFTP-------SAKYCQVV 49

  Fly   856 CTETMRRCGFFFDVFGLSLPEYLNCKLF---KDFPSSE-----DCVGLDEVREVM-RAATHPKCD 911
            ||...|                  |.||   .:.||.:     .||..|.|.|.: |........
Human    50 CTYHPR------------------CLLFTFTAESPSEDPTRWFTCVLKDSVTETLPRVNRTAAIS 96

  Fly   912 GFQCDQNRCLPQEYVC--DGHLDCMD------------QADEAKCERCGPDEIYC-----GDSQC 957
            |:...|  |..|...|  |.::| :|            .|.|.: ||| .|:::|     ...|.
Human    97 GYSFKQ--CSHQISACNKDIYVD-LDMKGINYNSSVAKSAQECQ-ERC-TDDVHCHFFTYATRQF 156

  Fly   958 IGTKHICDGIIDCPYGQDERNCLRLSERNGDVGTGVLEVYRIGQRQWMPACV------------- 1009
            ...:|              ||...|........|.:.::.::.....:.:|.
Human   157 PSLEH--------------RNICLLKHTQTGTPTRITKLDKVVSGFSLKSCALSNLACIRDIFPN 207

  Fly  1010 -----KNWDRAVSPSA-VCSILGYSAVNATSVLTQLTHRPLLATVNVSTDIWKMYAKR------- 1061
                 .|.|..::|.| ||..:             .||.|........:..|...::|
Human   208 TVFADSNIDSVMAPDAFVCGRI-------------CTHHPGCLFFTFFSQEWPKESQRNLCLLKT 259

  Fly  1062 -----------KSTLMQEFA--NCK---------------------------KTED--------- 1077
                       ||..:..|:  :|:                           |:.:
Human   260 SESGLPSTRIKKSKALSGFSLQSCRHSIPVFCHSSFYHDTDFLGEELDIVAAKSHEACQKLCTNA 324

  Fly  1078 -------YPMADLTC-------------SNYECGRVKRGRH--------------------KPSR 1102
                   |..|..:|             ||....::..||.                    ||
Human   325 VRCQFFTYTPAQASCNEGNRGKCYLKLSSNGSPTKILHGRGGISGYTLRLCKMDNECTTKIKP-- 387

  Fly  1103 RIIGGTQASPGNWPFLAAI-LGGPEKIFYCAGVLISDQWVLTASHCVGNYSVIDLEDWTIQLGVT 1166
            ||:|||.:..|.||:...: ...|.:...|.|.:|.:||:|||:||.  |.|...:...:..|:.
Human   388 RIVGGTASVRGEWPWQVTLHTTSPTQRHLCGGSIIGNQWILTAAHCF--YGVESPKILRVYSGIL 450

  Fly  1167 RRNSFTYSGQKVKVKAVIPHPQYNMAIAHDNDIALFQLATRVAFHEHLLPVCLPPPSVRNLHPGT 1231
            .::..........|:.:|.|.||.|| ....||||.:|.|.|.:.:...|:|||....||: ..|
Human   451 NQSEIKEDTSFFGVQEIIIHDQYKMA-ESGYDIALLKLETTVNYTDSQRPICLPSKGDRNV-IYT 513

  Fly  1232 LCTVIGWGKREDKDPKSTYEYIVNEVQVPIITRNQCDEWLDNLTVSEGMVCAGFDDGGKDACQGD 1296
            .|.|.|||.|:.:|   ..:..:.:.::|::|..:|.:......::..|:|||:.:||||||:||
Human   514 DCWVTGWGYRKLRD---KIQNTLQKAKIPLVTNEECQKRYRGHKITHKMICAGYREGGKDACKGD 575

  Fly  1297 SGGPLLCPYPGEKNRWFVGGIVSWGIMCAHPRLPGVYANVVQYVPWIQEQ 1346
            |||||.|.:   ...|.:.||.|||..||....||||.|||:||.||.|:
Human   576 SGGPLSCKH---NEVWHLVGITSWGEGCAQRERPGVYTNVVEYVDWILEK 622

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Corin	NP_610297.2	CRD_FZ	778..894	CDD:143549	22/110 (20%)
		LDLa	911..942	CDD:238060	10/44 (23%)
		LDLa	945..979	CDD:238060	6/38 (16%)
		SR	980..>1034	CDD:214555	9/72 (13%)
		Tryp_SPc	1104..1346	CDD:238113	89/242 (37%)
F11	XP_005262878.1	APPLE	20..103	CDD:128519	25/119 (21%)
		APPLE	110..193	CDD:128519	17/99 (17%)
		APPLE	200..283	CDD:128519	14/95 (15%)
		APPLE	291..375	CDD:128519	8/83 (10%)
		Tryp_SPc	389..619	CDD:238113	87/239 (36%)