Protein Alignment Corin and F10

DIOPT Version :10

• Sequence 1: NP_610297.2
• Gene: Corin / 35691
• FlyBaseID: FBgn0033192
• Length: 1397
• Species: Drosophila melanogaster
• Sequence 2: NP_000495.1
• Gene: F10 / 2159
• HGNCID: 3528
• Length: 488
• Species: Homo sapiens
• Alignment Length: 523
• Identity: 134/523 - (25%)
• Similarity: 227/523 - (43%)
• Gaps: 124/523 - (23%)

  Fly   890 EDCVGLDEVREVMRAAT------HPKCDGFQCDQNRCLPQ--------EYVCDGHLDCMDQADEA 940
            |:....:|.|||...:.      :...||.||:.:.|..|        ||.|    .|::..:..
Human    59 EETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTC----TCLEGFEGK 119

  Fly   941 KCERCGPDEIYCGDSQCIGTKHIC---DGIIDC-PYGQDERNCLRLSERNG----DVGTGVLEV- 996
            .||              :.|:.:|   :|  || .:..:|:|.:..|...|    |.|...:..
Human   120 NCE--------------LFTRKLCSLDNG--DCDQFCHEEQNSVVCSCARGYTLADNGKACIPTG 168

  Fly   997 -YRIGQRQWMPACVKNWDRAVSPSAVCSILGYSAVNATSVLTQLTHRPLLATVNVSTDIWKMYAK 1060
             |..|::     .::...|:|:.:.      .|:..|...:|                 ||.|
Human   169 PYPCGKQ-----TLERRKRSVAQAT------SSSGEAPDSIT-----------------WKPY-- 203

  Fly  1061 RKSTLMQEFANCKKTED-YPMADLTCSNYECGRVKRGRHKPSRRIIGGTQASPGNWPFLAAILGG 1124
                   :.|:...||: :.:.|...:..|     ||.:..: ||:||.:...|..|: .|:|..
Human   204 -------DAADLDPTENPFDLLDFNQTQPE-----RGDNNLT-RIVGGQECKDGECPW-QALLIN 254

  Fly  1125 PEKIFYCAGVLISDQWVLTASHCVGNYSVIDLEDWTIQLGVTRRNSFTYSGQKV-KVKAVIPHPQ 1188
            .|...:|.|.::|:.::|||:||     :...:.:.:::| .|.......|:.| :|:.||.|.:
Human   255 EENEGFCGGTILSEFYILTAAHC-----LYQAKRFKVRVG-DRNTEQEEGGEAVHEVEVVIKHNR 313

  Fly  1189 YNMAIAHDNDIALFQLATRVAFHEHLLPVCLPPPSVRNLHPGTLCT-----VIGWGKREDKDPKS 1248
            :... .:|.|||:.:|.|.:.|..::.|.|||.   |:....||.|     |.|:|:..:|..:|
Human   314 FTKE-TYDFDIAVLRLKTPITFRMNVAPACLPE---RDWAESTLMTQKTGIVSGFGRTHEKGRQS 374

  Fly  1249 TYEYIVNEVQVPIITRNQCDEWLDNLTVSEGMVCAGFDDGGKDACQGDSGGPLLCPYPGEKNRWF 1313
            |.   :..::||.:.||.| :...:..:::.|.|||:|...:||||||||||.:..:   |:.:|
Human   375 TR---LKMLEVPYVDRNSC-KLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRF---KDTYF 432

  Fly  1314 VGGIVSWGIMCAHPRLPGVYANVVQYVPWIQEQIAKHSRPIKEDRVNKYDLHPGGPDILSKIATD 1378
            |.||||||..||.....|:|..|..::.||       .|.:|...:.|...|  .|::   |.:.
Human   433 VTGIVSWGEGCARKGKYGIYTKVTAFLKWI-------DRSMKTRGLPKAKSH--APEV---ITSS 485

  Fly  1379 PMR 1381
            |::
Human   486 PLK 488

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Corin	NP_610297.2	CRD_FZ	778..894	CDD:143549	1/3 (33%)
		LDLa	911..942	CDD:238060	10/38 (26%)
		LDLa	945..979	CDD:238060	6/37 (16%)
		SR	980..>1034	CDD:214555	10/59 (17%)
		Tryp_SPc	1104..1346	CDD:238113	81/247 (33%)
F10	NP_000495.1	GLA	25..85	CDD:214503	5/25 (20%)
		EGF_CA	86..122	CDD:238011	10/39 (26%)
		FXa_inhibition	129..164	CDD:464251	10/36 (28%)
		O-glycosylated at one site	183..203		6/42 (14%)
		Tryp_SPc	235..464	CDD:238113	81/253 (32%)
		O-glycosylated at one site	476..485		3/13 (23%)