Protein Alignment Corin and F9

DIOPT Version :10

• Sequence 1: NP_610297.2
• Gene: Corin / 35691
• FlyBaseID: FBgn0033192
• Length: 1397
• Species: Drosophila melanogaster
• Sequence 2: NP_000124.1
• Gene: F9 / 2158
• HGNCID: 3551
• Length: 461
• Species: Homo sapiens
• Alignment Length: 521
• Identity: 133/521 - (25%)
• Similarity: 211/521 - (40%)
• Gaps: 128/521 - (24%)

  Fly   863 CGFFFDVFG----LSLPEYLNCKLFKDFPSS-------EDCVGLDEVREVMRAATHPK------C 910
            |..|.|...    |:.|:..|....::|...       |:....:|.|||........      .
Human    28 CTVFLDHENANKILNRPKRYNSGKLEEFVQGNLERECMEEKCSFEEAREVFENTERTTEFWKQYV 92

  Fly   911 DGFQCDQNRCLPQEYVCDGHLDCMDQADEAKCERCGPDEIYCGDSQCIGTKHICDGIIDCPYGQD 975
            ||.||:.|.||      :|. .|.|..:..:|.                          ||:|.:
Human    93 DGDQCESNPCL------NGG-SCKDDINSYECW--------------------------CPFGFE 124

  Fly   976 ERNC---LRLSERNG------------DVGTGVLEVYRIGQRQWMPACVKNWDRAVSPSAVCSIL 1025
            .:||   :..:.:||            .|.....|.||:.:.|          ::..| ||....
Human   125 GKNCELDVTCNIKNGRCEQFCKNSADNKVVCSCTEGYRLAENQ----------KSCEP-AVPFPC 178

  Fly  1026 GYSAVNATSVLTQLTHRPLLATVNVSTDIWKMYAKRKSTLMQEFANCKKTEDYPMADLTCSNYEC 1090
            |..:|:.||.||:        ...|..|:..:.:....|::....  :.|:.:  .|.|
Human   179 GRVSVSQTSKLTR--------AETVFPDVDYVNSTEAETILDNIT--QSTQSF--NDFT------ 225

  Fly  1091 GRVKRGRHKPSRRIIGGTQASPGNWPFLAAILGGPEKIFYCAGVLISDQWVLTASHCVGNYSVID 1155
                        |::||..|.||.:|: ..:|.|....| |.|.:::::|::||:|||.....|
Human   226 ------------RVVGGEDAKPGQFPW-QVVLNGKVDAF-CGGSIVNEKWIVTAAHCVETGVKI- 275

  Fly  1156 LEDWTIQLGVTRRNSFTYSGQKVKVKAVIPHPQYNMAI-AHDNDIALFQLATRVAFHEHLLPVCL 1219
                |:..|........::.||..|..:|||..||.|| .:::||||.:|...:..:.::.|:|:
Human   276 ----TVVAGEHNIEETEHTEQKRNVIRIIPHHNYNAAINKYNHDIALLELDEPLVLNSYVTPICI 336

  Fly  1220 PPPSVRNLH----PGTLCTVIGWGKREDKDPKSTYEYIVNEVQVPIITRNQCDEWLDNLTVSEGM 1280
            ......|:.    .|   .|.|||:...|...:   .::..::||::.|..|.. ....|:...|
Human   337 ADKEYTNIFLKFGSG---YVSGWGRVFHKGRSA---LVLQYLRVPLVDRATCLR-STKFTIYNNM 394

  Fly  1281 VCAGFDDGGKDACQGDSGGPLLCPYPGEKNRWFVGGIVSWGIMCAHPRLPGVYANVVQYVPWIQE 1345
            .||||.:||:|:||||||||.:....|..   |:.||:|||..||.....|:|..|.:||.||:|
Human   395 FCAGFHEGGRDSCQGDSGGPHVTEVEGTS---FLTGIISWGEECAMKGKYGIYTKVSRYVNWIKE 456

  Fly  1346 Q 1346
            :
Human   457 K 457

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Corin	NP_610297.2	CRD_FZ	778..894	CDD:143549	8/41 (20%)
		LDLa	911..942	CDD:238060	10/30 (33%)
		LDLa	945..979	CDD:238060	3/33 (9%)
		SR	980..>1034	CDD:214555	12/65 (18%)
		Tryp_SPc	1104..1346	CDD:238113	81/246 (33%)
F9	NP_000124.1	GLA	28..92	CDD:214503	12/63 (19%)
		EGF_CA	93..129	CDD:238011	15/68 (22%)
		FXa_inhibition	134..170	CDD:464251	7/45 (16%)
		Tryp_SPc	227..457	CDD:238113	81/246 (33%)