DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Corin and Sfrp4

DIOPT Version :9

Sequence 1:	NP_610297.2	Gene:	Corin / 35691	FlyBaseID:	FBgn0033192	Length:	1397	Species:	Drosophila melanogaster
Sequence 2:	NP_057896.1	Gene:	Sfrp4 / 20379	MGIID:	892010	Length:	351	Species:	Mus musculus

Alignment Length:	201	Identity:	47/201 - (23%)
Similarity:	74/201 - (36%)	Gaps:	53/201 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly   769 SFGKNPAPGTCLPIIVRFCQGPQIPYNYTVFPNYIGHFGQLETQTDLDSYEALVDVRCYELVSLF 833
            :.|...||  |..:.:..|:  .:|:|.|..||::.|..|......::.||.||||.|..::..|
Mouse    16 ALGVRGAP--CEAVRIPMCR--HMPWNITRMPNHLHHSTQENAILAIEQYEELVDVNCSSVLRFF 76

  Fly   834 LCTLFVPKCGQSGATVP--PCKTLCTETMRRCGFFFDVFGLSLPEYLNC---------------K 881
            ||.::.|.|.......|  |||::|......|.....::..|.||.|.|               .
Mouse    77 LCAMYAPICTLEFLHDPIKPCKSVCQRARDDCEPLMKMYNHSWPESLACDELPVYDRGVCISPEA 141

  Fly   882 LFKDFPSSEDCVGLDEVREVMRAATHPKCDGFQCDQNRCLPQEYVCDGHLDCMDQADEAKCERCG 946
            :..|.|  ||...:|...::|                              ..:::.:|.|:|..
Mouse   142 IVTDLP--EDVKWIDITPDMM------------------------------VQERSFDADCKRLS 174

  Fly   947 PDEIYC 952
            ||...|
Mouse   175 PDRCKC 180

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Corin	NP_610297.2	CRD_FZ	778..894	CDD:143549	36/132 (27%)
		LDLa	911..942	CDD:238060	1/30 (3%)
		LDLa	945..979	CDD:238060	3/8 (38%)
		SR	980..>1034	CDD:214555
		SRCR	992..1086	CDD:278931
		Tryp_SPc	1103..1343	CDD:214473
		Tryp_SPc	1104..1346	CDD:238113
Sfrp4	NP_057896.1	CRD_FZ	20..146	CDD:295308	34/129 (26%)
		NTR_like	188..296	CDD:295338
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	293..351
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3577
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900