DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Corin and sfrp-1

DIOPT Version :9

Sequence 1:	NP_610297.2	Gene:	Corin / 35691	FlyBaseID:	FBgn0033192	Length:	1397	Species:	Drosophila melanogaster
Sequence 2:	NP_500977.2	Gene:	sfrp-1 / 177401	WormBaseID:	WBGene00022242	Length:	314	Species:	Caenorhabditis elegans

Alignment Length:	298	Identity:	67/298 - (22%)
Similarity:	111/298 - (37%)	Gaps:	55/298 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly   748 YPTIKFVNKTIINTIHVEDTTSF--GKNPAPGTC--LPIIVRFCQGPQIPYNYTVFPNYIGHFGQ 808
            :|.:..:....:...::||:.:.  .:.|....|  :|..:..|.|  |.|.....||.:.|...
Worm     4 FPVLYILFAFSVTNGYLEDSWAMFSSERPVGPKCVDIPSNLSICNG--IEYTQMRLPNILEHETV 66

  Fly   809 LETQTDLDSYEALVDVRCYELVSLFLCTLFVPKC-GQSGATVPPCKTLCTETMRRCGFFFDVFGL 872
            .|.......:|:|:.:.|:.....|||:||.|.| .|....:.|||:||....:.|......:|.
Worm    67 SEAIHASKDWESLLRLNCHPDTQRFLCSLFAPVCLMQMDRLILPCKSLCMAVKQGCENRMANYGF 131

  Fly   873 SLPEYLNCKLFKDFPSSEDCVGLDEVREVMRAATHPKCDGFQCDQNRC--------LPQEYVCDG 929
            ..||.|:|:.|:|   .:.|:      :.|:.|..|......|  ..|        |..:: |..
Worm   132 PWPEMLSCEKFED---DDMCI------KPMQPAKPPAGSSTTC--TACSQVATYENLVDQF-CRS 184

  Fly   930 HLDCMDQADEAKCERCGPDEIYCGDSQCI-------GTKHI-------CDGIIDC--PYGQDERN 978
            ||     ..:||..|..|..|...:.:.:       |...:       .||...|  |.......
Worm   185 HL-----VLKAKVIRDSPTHIRVRNGRSLKKGERRRGVSDVEIRLSSESDGSCPCNIPVKNQNEK 244

  Fly   979 CLRLSERNGDVGTGVLEVYRIGQRQWMPACVKNWDRAV 1016
            .|.::.|..| |..:..:....|::      ||:.||:
Worm   245 LLVMASRQPD-GKYLANLVLPWQKE------KNFKRAI 275

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Corin	NP_610297.2	CRD_FZ	778..894	CDD:143549	35/118 (30%)
		LDLa	911..942	CDD:238060	7/38 (18%)
		LDLa	945..979	CDD:238060	7/49 (14%)
		SR	980..>1034	CDD:214555	9/37 (24%)
		SRCR	992..1086	CDD:278931	5/25 (20%)
		Tryp_SPc	1103..1343	CDD:214473
		Tryp_SPc	1104..1346	CDD:238113
sfrp-1	NP_500977.2	CRD_FZ	37..161	CDD:382974	38/134 (28%)
sfrp-1	NP_500977.2	NTR_Sfrp1_like	162..283	CDD:239635	25/129 (19%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3577
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810