DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Corin and Fzd9

DIOPT Version :9

Sequence 1:	NP_610297.2	Gene:	Corin / 35691	FlyBaseID:	FBgn0033192	Length:	1397	Species:	Drosophila melanogaster
Sequence 2:	NP_034376.1	Gene:	Fzd9 / 14371	MGIID:	1313278	Length:	592	Species:	Mus musculus

Alignment Length:	304	Identity:	71/304 - (23%)
Similarity:	104/304 - (34%)	Gaps:	97/304 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly   771 GKNPAPGTCLPIIVRFCQGPQIPYNYTVFPNYIGHFGQLETQTDLDSYEALVDVRCYELVSLFLC 835
            |:.|||  |..:.:..|:|  |.||.|..||.:||..|.|....|..:..||...|:..:..|||
Mouse    34 GRGPAP--CQAMEIPMCRG--IGYNLTRMPNLLGHTSQGEAAAQLAEFSPLVQYGCHSHLRFFLC 94

  Fly   836 TLFVPKC-GQSGATVPPCKTLCTETMRRCGFFFDVFGLSLPEYLNCKLFKDFPSSEDCVGLDEVR 899
            :|:.|.| .|....:|.|:.:|.:...||....:.|....|:.|:|..
Mouse    95 SLYAPMCTDQVSTPIPACRPMCEQARLRCAPIMEQFNFGWPDSLDCAR----------------- 142

  Fly   900 EVMRAATHPKCDGFQCDQNRCLPQEYVCDGHLDCMDQADEAKCERCGPDEIYCG----------- 953
                                 ||...  |.|..||:..:.|   ..||.|.:.|
Mouse   143 ---------------------LPTRN--DPHALCMEAPENA---TAGPTEPHKGLGMLPVAPRPA 181

  Fly   954 -----DSQCIGTKHICDGIIDCPYGQDERNCLRLSERNGDVGTGVLEVYRIGQRQWMPACVKNWD 1013
                 .:...|:...||......|.:..|:|   :.|   .|.|| ||:              |.
Mouse   182 RPPGDSAPGPGSGGTCDNPEKFQYVEKSRSC---APR---CGPGV-EVF--------------WS 225

  Fly  1014 RAVSPSAVCSILGYSAV----NATSVLT--------QLTHRPLL 1045
            |.....|:..:..:||:    .|.:|.|        |...||::
Mouse   226 RRDKDFALVWMAVWSALCFFSTAFTVFTFLLEPHRFQYPERPII 269

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Corin	NP_610297.2	CRD_FZ	778..894	CDD:143549	33/116 (28%)
		LDLa	911..942	CDD:238060	7/30 (23%)
		LDLa	945..979	CDD:238060	9/49 (18%)
		SR	980..>1034	CDD:214555	12/57 (21%)
		SRCR	992..1086	CDD:278931	15/66 (23%)
		Tryp_SPc	1103..1343	CDD:214473
		Tryp_SPc	1104..1346	CDD:238113
Fzd9	NP_034376.1	CRD_FZ9	36..162	CDD:143572	43/172 (25%)
		Required for Wnt-activated receptor activity. /evidence=ECO:0000250\|UniProtKB:Q8K4C8	59..173		37/156 (24%)
		7tmF_FZD9	222..543	CDD:320164	12/62 (19%)
		TM helix 1	231..256	CDD:320164	6/24 (25%)
		TM helix 2	265..286	CDD:320164	2/5 (40%)
		TM helix 3	315..341	CDD:320164
		TM helix 4	358..374	CDD:320164
		TM helix 5	396..426	CDD:320164
		TM helix 6	445..472	CDD:320164
		TM helix 7	504..529	CDD:320164
		Lys-Thr-X-X-X-Trp motif, mediates interaction with the PDZ domain of Dvl family members. /evidence=ECO:0000250	533..538
		Required for CTNNB1 accumulation and TCF transcription factor activity. /evidence=ECO:0000250\|UniProtKB:Q8K4C8	555..592
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3577
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	2	1.900