DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Corin and Fzd5

DIOPT Version :9

Sequence 1:	NP_610297.2	Gene:	Corin / 35691	FlyBaseID:	FBgn0033192	Length:	1397	Species:	Drosophila melanogaster
Sequence 2:	NP_001036124.1	Gene:	Fzd5 / 14367	MGIID:	108571	Length:	585	Species:	Mus musculus

Alignment Length:	330	Identity:	70/330 - (21%)
Similarity:	114/330 - (34%)	Gaps:	76/330 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly   775 APGTCLPIIVRFCQGPQIPYNYTVFPNYIGHFGQLETQTDLDSYEALVDVRCYELVSLFLCTLFV 839
            || .|..|.|..|:|  |.||.|..||...|..|.|...::..:..||::.|...:..|||:::.
Mouse    30 AP-VCQEITVPMCRG--IGYNLTHMPNQFNHDTQDEAGLEVHQFWPLVEIHCSPDLRFFLCSMYT 91

  Fly   840 PKC-GQSGATVPPCKTLCTETMRRCGFFFDVFGLSLPEYLNCKLFKDFPSSEDCVGLDEVREVMR 903
            |.| ......:|||:::|......|......:|.:.||.::|..........:.:.:|..|....
Mouse    92 PICLPDYHKPLPPCRSVCERAKAGCSPLMRQYGFAWPERMSCDRLPVLGGDAEVLCMDYNRSEAT 156

  Fly   904 AATHPKCDGFQCDQNRCLPQEYVCDGHLDCMDQADEAKCERCGPDEIYCGDS------------Q 956
            .|: ||          ..|.:....|.........|  |...||....|.:.            .
Mouse   157 TAS-PK----------SFPAKPTLPGPPGAPSSGGE--CPSGGPSVCTCREPFVPILKESHPLYN 208

  Fly   957 CIGTKHICDGIIDC---PYGQDER----------NCLRLSERNGDVGTGVLEV--YRIGQRQ--W 1004
            .:.|..:.:..:.|   .:..|||          :.|.....:..|.|.::::  :|..:|.  :
Mouse   209 KVRTGQVPNCAVPCYQPSFSPDERTFATFWIGLWSVLCFISTSTTVATFLIDMERFRYPERPIIF 273

  Fly  1005 MPACVKNWDRAVSPSAVCSILGY---SAVNATSVLTQLTHR--------PLLATV--------NV 1050
            :.||.           :|..||:   ..|...||.....|.        |.|.||        .:
Mouse   274 LSACY-----------LCVSLGFLVRLVVGHASVACSREHSHIHYETTGPALCTVVFLLVYFFGM 327

  Fly  1051 STDIW 1055
            ::.||
Mouse   328 ASSIW 332

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Corin	NP_610297.2	CRD_FZ	778..894	CDD:143549	31/116 (27%)
		LDLa	911..942	CDD:238060	3/30 (10%)
		LDLa	945..979	CDD:238060	8/58 (14%)
		SR	980..>1034	CDD:214555	11/60 (18%)
		SRCR	992..1086	CDD:278931	17/87 (20%)
		Tryp_SPc	1103..1343	CDD:214473
		Tryp_SPc	1104..1346	CDD:238113
Fzd5	NP_001036124.1	CRD_FZ5	29..156	CDD:143569	35/128 (27%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	156..182		6/38 (16%)
		7tm_GPCRs	225..535	CDD:333717	23/119 (19%)
		TM helix 1	235..259	CDD:320095	3/23 (13%)
		TM helix 2	268..289	CDD:320095	6/31 (19%)
		TM helix 3	316..338	CDD:320095	4/17 (24%)
		TM helix 4	359..375	CDD:320095
		TM helix 5	397..420	CDD:320095
		TM helix 6	448..473	CDD:320095
		TM helix 7	496..521	CDD:320095
		PDZ-binding. /evidence=ECO:0000250	582..584
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3577
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	2	1.900