DRSC/TRiP Functional Genomics Resources

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Protein Alignment Corin and Fzd4

DIOPT Version :9

Sequence 1:NP_610297.2 Gene:Corin / 35691 FlyBaseID:FBgn0033192 Length:1397 Species:Drosophila melanogaster
Sequence 2:NP_032081.3 Gene:Fzd4 / 14366 MGIID:108520 Length:537 Species:Mus musculus


Alignment Length:191 Identity:53/191 - (27%)
Similarity:80/191 - (41%) Gaps:26/191 - (13%)


- Green bases have known domain annotations that are detailed below.


  Fly   767 TTSFGKNPAPGTCLPIIVRFCQGPQIPYNYTVFPNYIGHFGQLETQTDLDSYEALVDVRCYELVS 831
            |..|| :.....|.||.:..||  .:.||.|..||.:||..|.:.:..|.::..|:...|...:.
Mouse    34 TLGFG-DEEERRCDPIRIAMCQ--NLGYNVTKMPNLVGHELQTDAELQLTTFTPLIQYGCSSQLQ 95

  Fly   832 LFLCTLFVPKCGQS-GATVPPCKTLCTETMRRCGFFFDVFGLSLPEYLNCKLFKDFPSSED---- 891
            .|||:::||.|.:. ...:.||..:|....|||......||.:.|:.|||   ..||...|    
Mouse    96 FFLCSVYVPMCTEKINIPIGPCGGMCLSVKRRCEPVLREFGFAWPDTLNC---SKFPPQNDHNHM 157

  Fly   892 CV---GLDEVREVMRAATHPKCDGFQCDQNRCLPQEYV-CDGHLDCMDQADEAKCERCGPD 948
            |:   |.:||....:....|   |.:|........:|: ....|:|:        .:||.|
Mouse   158 CMEGPGDEEVPLPHKTPIQP---GEECHSVGSNSDQYIWVKRSLNCV--------LKCGYD 207

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
CorinNP_610297.2 CRD_FZ 778..894 CDD:143549 38/123 (31%)
LDLa 911..942 CDD:238060 5/31 (16%)
LDLa 945..979 CDD:238060 3/4 (75%)
SR 980..>1034 CDD:214555
SRCR 992..1086 CDD:278931
Tryp_SPc 1103..1343 CDD:214473
Tryp_SPc 1104..1346 CDD:238113
Fzd4NP_032081.3 CRD_FZ4 42..167 CDD:143557 39/129 (30%)
Frizzled 210..509 CDD:279827
Lys-Thr-X-X-X-Trp motif, mediates interaction with the PDZ domain of Dvl family members. /evidence=ECO:0000250 499..504
PDZ-binding 535..537
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_KOG3577
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 1 1.000 - -
TreeFam 00.000 Not matched by this tool.
21.900

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