Protein Alignment Corin and Fzd3

DIOPT Version :10

• Sequence 1: NP_610297.2
• Gene: Corin / 35691
• FlyBaseID: FBgn0033192
• Length: 1397
• Species: Drosophila melanogaster
• Sequence 2: NP_067433.1
• Gene: Fzd3 / 14365
• MGIID: 108476
• Length: 666
• Species: Mus musculus
• Alignment Length: 758
• Identity: 147/758 - (19%)
• Similarity: 241/758 - (31%)
• Gaps: 266/758 - (35%)

  Fly   778 TCLPIIVRFCQGPQIPYNYTVFPNYIGHFGQLETQTDLDSYEALVDVRCYELVSLFLCTLFVPKC 842
            :|.||.:|.||  .:|||.|..||.:.|:.|......::.:..:|::.|......|||.|:.|.|
Mouse    27 SCEPITLRMCQ--DLPYNTTFMPNLLNHYDQQTAALAMEPFHPMVNLDCSRDFRPFLCALYAPIC 89

  Fly   843 GQSGATVPPCKTLCTETMRRCGFFFDVFGLSLPEYLNCKLFKD----FPSSEDCVGLDEVREVMR 903
            .:.|....||:.||......|....::||:..||.:.|..|.|    :|...|...:.:..|...
Mouse    90 MEYGRVTLPCRRLCQRAYSECSKLMEMFGVPWPEDMECSRFPDCDEPYPRLVDLNLVGDPTEGAP 154

  Fly   904 AATHPKCDGFQCDQNRCLPQEYVCDGHLDCMDQADEAKCERCGPDEIYCGDSQCIGTKHICDGII 968
            .|.. :..||.|      |:|...|                  ||..|       ...|:.|...
Mouse   155 VAVQ-RDYGFWC------PRELKID------------------PDLGY-------SFLHVRDCSP 187

  Fly   969 DCP---YGQDERNCLRLSERNGDVGTGVLEVYRIGQRQWMPACVKNWDRAVSPSAVCSILGYSAV 1030
            .||   :.::|.:..|               |.||                    :.||:..||.
Mouse   188 PCPNMYFRREELSFAR---------------YFIG--------------------LISIICLSAT 217

  Fly  1031 NAT--SVLTQLT-----HRPLL----ATVNVSTDIWKMYAKRKSTLMQEFANCKKTEDYPMADLT 1084
            ..|  :.|..:|     .||::    ..:.||...:..:      |:::...|..:..
Mouse   218 LFTFLTFLIDVTRFRYPERPIIFYAVCYMMVSLIFFIGF------LLEDRVACNASSP------- 269

  Fly  1085 CSNYECGRVKRGRHKPSRRII-----GGTQASPGNWP------FLAAI-LGGPEKIFYCAGVLIS 1137
             :.|:...|.:|.|..:..::     ..|.|....|.      ||||: ..|.|.|...|.:..:
Mouse   270 -AQYKASTVTQGSHNKACTMLFMVLYFFTMAGSVWWVILTITWFLAAVPKWGSEAIEKKALLFHA 333

  Fly  1138 DQW--------VLTASH----------C-VGNYSV--------------------------IDLE 1157
            ..|        :|.|.:          | ||.|.|                          |.|.
Mouse   334 SAWGIPGTLTIILLAMNKIEGDNISGVCFVGLYDVDALRYFVLAPLCLYVVVGVSLLLAGIISLN 398

  Fly  1158 DWTIQLGVTRRNS------------FT-------------------YSG-------QKVKVKAVI 1184
            ...|::.:.:.|.            |:                   |.|       |:...:..|
Mouse   399 RVRIEIPLEKENQDKLVKFMIRIGVFSILYLVPLLVVIGCYFYEQAYRGIWETTWIQERCREYHI 463

  Fly  1185 PHPQYNMAIAHDNDIALFQLATRVAFHEHLLPVCLPPPSVRNLHPGTLCTVIGW-----GKREDK 1244
            |.| |.:......|:.||.:       ::|:.:.:..||:  ...|:..|...|     |:|:.:
Mouse   464 PCP-YQVTQMSRPDLILFLM-------KYLMALIVGIPSI--FWVGSKKTCFEWASFFHGRRKKE 518

  Fly  1245 DPKSTYEYIVNEVQ-----------------VPIITRNQCDEWLDNLTVSEGMVCAGFDDGGKDA 1292
                    ||||.:                 .|||.:::........|.:.....|..||
Mouse   519 --------IVNESRQVLQEPDFAQSLLRDPNTPIIRKSRGTSTQGTSTHASSTQLAMVDD----- 570

  Fly  1293 CQGDSGGPL---LCPYPGEKNRWFVGGIVSWGIMCAHPRLPGVYANVVQYVP-WIQEQIAKHSRP 1353
             |....|.:   :..|.|..:|...|...           |..|..:.:.:| ....::..|||.
Mouse   571 -QRSKAGSVHSKVSSYHGSLHRSRDGRYT-----------PCSYRGMEERLPHGSMSRLTDHSRH 623

  Fly  1354 IKEDRVNKYDLHPGGPDILSKIATDPMREGAPHHYTHSRTSSK 1396
            ....|:|:...|..    :..::.:||.     |.||..:.::
Mouse   624 SSSHRLNEQSRHSS----IRDLSNNPMT-----HITHGTSMNR 657

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Corin	NP_610297.2	CRD_FZ	778..894	CDD:143549	37/119 (31%)
		LDLa	911..942	CDD:238060	6/30 (20%)
		LDLa	945..979	CDD:238060	8/36 (22%)
		SR	980..>1034	CDD:214555	9/55 (16%)
		Tryp_SPc	1104..1346	CDD:238113	62/362 (17%)
Fzd3	NP_067433.1	CRD_FZ3	24..150	CDD:143558	37/124 (30%)
		7tmF_FZD3	192..512	CDD:320161	62/378 (16%)
		TM helix 1	201..226	CDD:320161	9/59 (15%)
		TM helix 2	235..256	CDD:320161	4/20 (20%)
		TM helix 3	287..313	CDD:320161	3/25 (12%)
		TM helix 4	330..352	CDD:320161	3/21 (14%)
		TM helix 5	366..391	CDD:320161	2/24 (8%)
		TM helix 6	419..444	CDD:320161	1/24 (4%)
		TM helix 7	473..498	CDD:320161	6/33 (18%)
		Lys-Thr-X-X-X-Trp motif, mediates interaction with the PDZ domain of Dvl family members. /evidence=ECO:0000250	502..507		1/4 (25%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	538..666		27/146 (18%)