DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Corin and Fzd3

DIOPT Version :9

Sequence 1:	NP_610297.2	Gene:	Corin / 35691	FlyBaseID:	FBgn0033192	Length:	1397	Species:	Drosophila melanogaster
Sequence 2:	NP_067433.1	Gene:	Fzd3 / 14365	MGIID:	108476	Length:	666	Species:	Mus musculus

Alignment Length:	758	Identity:	147/758 - (19%)
Similarity:	241/758 - (31%)	Gaps:	266/758 - (35%)

- Green bases have known domain annotations that are detailed below.

  Fly   778 TCLPIIVRFCQGPQIPYNYTVFPNYIGHFGQLETQTDLDSYEALVDVRCYELVSLFLCTLFVPKC 842
            :|.||.:|.||  .:|||.|..||.:.|:.|......::.:..:|::.|......|||.|:.|.|
Mouse    27 SCEPITLRMCQ--DLPYNTTFMPNLLNHYDQQTAALAMEPFHPMVNLDCSRDFRPFLCALYAPIC 89

  Fly   843 GQSGATVPPCKTLCTETMRRCGFFFDVFGLSLPEYLNCKLFKD----FPSSEDCVGLDEVREVMR 903
            .:.|....||:.||......|....::||:..||.:.|..|.|    :|...|...:.:..|...
Mouse    90 MEYGRVTLPCRRLCQRAYSECSKLMEMFGVPWPEDMECSRFPDCDEPYPRLVDLNLVGDPTEGAP 154

  Fly   904 AATHPKCDGFQCDQNRCLPQEYVCDGHLDCMDQADEAKCERCGPDEIYCGDSQCIGTKHICDGII 968
            .|.. :..||.|      |:|...|                  ||..|       ...|:.|...
Mouse   155 VAVQ-RDYGFWC------PRELKID------------------PDLGY-------SFLHVRDCSP 187

  Fly   969 DCP---YGQDERNCLRLSERNGDVGTGVLEVYRIGQRQWMPACVKNWDRAVSPSAVCSILGYSAV 1030
            .||   :.::|.:..|               |.||                    :.||:..||.
Mouse   188 PCPNMYFRREELSFAR---------------YFIG--------------------LISIICLSAT 217

  Fly  1031 NAT--SVLTQLT-----HRPLL----ATVNVSTDIWKMYAKRKSTLMQEFANCKKTEDYPMADLT 1084
            ..|  :.|..:|     .||::    ..:.||...:..:      |:::...|..:..
Mouse   218 LFTFLTFLIDVTRFRYPERPIIFYAVCYMMVSLIFFIGF------LLEDRVACNASSP------- 269

  Fly  1085 CSNYECGRVKRGRHKPSRRII-----GGTQASPGNWP------FLAAI-LGGPEKIFYCAGVLIS 1137
             :.|:...|.:|.|..:..::     ..|.|....|.      ||||: ..|.|.|...|.:..:
Mouse   270 -AQYKASTVTQGSHNKACTMLFMVLYFFTMAGSVWWVILTITWFLAAVPKWGSEAIEKKALLFHA 333

  Fly  1138 DQW--------VLTASH----------C-VGNYSV--------------------------IDLE 1157
            ..|        :|.|.:          | ||.|.|                          |.|.
Mouse   334 SAWGIPGTLTIILLAMNKIEGDNISGVCFVGLYDVDALRYFVLAPLCLYVVVGVSLLLAGIISLN 398

  Fly  1158 DWTIQLGVTRRNS------------FT-------------------YSG-------QKVKVKAVI 1184
            ...|::.:.:.|.            |:                   |.|       |:...:..|
Mouse   399 RVRIEIPLEKENQDKLVKFMIRIGVFSILYLVPLLVVIGCYFYEQAYRGIWETTWIQERCREYHI 463

  Fly  1185 PHPQYNMAIAHDNDIALFQLATRVAFHEHLLPVCLPPPSVRNLHPGTLCTVIGW-----GKREDK 1244
            |.| |.:......|:.||.:       ::|:.:.:..||:  ...|:..|...|     |:|:.:
Mouse   464 PCP-YQVTQMSRPDLILFLM-------KYLMALIVGIPSI--FWVGSKKTCFEWASFFHGRRKKE 518

  Fly  1245 DPKSTYEYIVNEVQ-----------------VPIITRNQCDEWLDNLTVSEGMVCAGFDDGGKDA 1292
                    ||||.:                 .|||.:::........|.:.....|..||
Mouse   519 --------IVNESRQVLQEPDFAQSLLRDPNTPIIRKSRGTSTQGTSTHASSTQLAMVDD----- 570

  Fly  1293 CQGDSGGPL---LCPYPGEKNRWFVGGIVSWGIMCAHPRLPGVYANVVQYVP-WIQEQIAKHSRP 1353
             |....|.:   :..|.|..:|...|...           |..|..:.:.:| ....::..|||.
Mouse   571 -QRSKAGSVHSKVSSYHGSLHRSRDGRYT-----------PCSYRGMEERLPHGSMSRLTDHSRH 623

  Fly  1354 IKEDRVNKYDLHPGGPDILSKIATDPMREGAPHHYTHSRTSSK 1396
            ....|:|:...|..    :..::.:||.     |.||..:.::
Mouse   624 SSSHRLNEQSRHSS----IRDLSNNPMT-----HITHGTSMNR 657

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Corin	NP_610297.2	CRD_FZ	778..894	CDD:143549	37/119 (31%)
		LDLa	911..942	CDD:238060	6/30 (20%)
		LDLa	945..979	CDD:238060	8/36 (22%)
		SR	980..>1034	CDD:214555	9/55 (16%)
		SRCR	992..1086	CDD:278931	16/104 (15%)
		Tryp_SPc	1103..1343	CDD:214473	62/360 (17%)
		Tryp_SPc	1104..1346	CDD:238113	62/362 (17%)
Fzd3	NP_067433.1	CRD_FZ3	24..150	CDD:143558	37/124 (30%)
		Frizzled	193..512	CDD:279827	62/377 (16%)
		Lys-Thr-X-X-X-Trp motif, mediates interaction with the PDZ domain of Dvl family members. /evidence=ECO:0000250	502..507		1/4 (25%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	538..666		27/146 (18%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3577
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	2	1.900