Protein Alignment Corin and F7

DIOPT Version :10

• Sequence 1: NP_610297.2
• Gene: Corin / 35691
• FlyBaseID: FBgn0033192
• Length: 1397
• Species: Drosophila melanogaster
• Sequence 2: NP_034302.2
• Gene: F7 / 14068
• MGIID: 109325
• Length: 446
• Species: Mus musculus
• Alignment Length: 497
• Identity: 118/497 - (23%)
• Similarity: 183/497 - (36%)
• Gaps: 168/497 - (33%)

  Fly   888 SSEDCVGLDEVREVMRAATHPK------CDGFQCDQNRCLPQEYVCDGHLD-----CMDQADEAK 941
            :.|.| ..:|.||:.::....|      .||.||..|.| .....|..||.     |:...:...
Mouse    59 NEEQC-SFEEAREIFKSPERTKQFWIVYSDGDQCASNPC-QNGGTCQDHLKSYVCFCLLDFEGRN 121

  Fly   942 CERCGPDEIYCG------DSQC---IGTKHICDGIIDCPYGQDERNCLRLSERNGDVGTGVLEVY 997
            ||:...:::.|.      |..|   :|||..|
Mouse   122 CEKSKNEQLICANENGDCDQYCRDHVGTKRTC--------------------------------- 153

  Fly   998 RIGQRQWMPACVKNWDRAVSPSAVCSILGYSAVNATSVLTQLTHRPLLATVNVSTDIWKMYAKRK 1062
                     :|.:::
Mouse   154 ---------SCHEDY-------------------------------------------------- 159

  Fly  1063 STLMQEFANCKKTEDYPMADLTCSNYECGRV----KRGRHKPSRRIIGGTQASPGNWPFLAAI-L 1122
             ||..:..:||...:||          |||:    ||.......||:||.....|..|:.|.: :
Mouse   160 -TLQPDEVSCKPKVEYP----------CGRIPVVEKRNSSSRQGRIVGGNVCPKGECPWQAVLKI 213

  Fly  1123 GGPEKIFYCAGVLISDQWVLTASHCVGNYSVIDLEDW---TIQLGVTRRNSFTYSGQKVKVK--- 1181
            .|   :..|..||:..:|::||:||..|     :..|   |:.:|   .:.|:......:|:
Mouse   214 NG---LLLCGAVLLDARWIVTAAHCFDN-----IRYWGNITVVMG---EHDFSEKDGDEQVRRVT 267

  Fly  1182 -AVIPHPQYNMAIAHDNDIALFQLATRVAFHEHLLPVCLPPPSVRNLHPGTLC-----TVIGWGK 1240
             .::|.......|.|  ||||.:|...|.|.::::|:|||.   ::....||.     .|.|||:
Mouse   268 QVIMPDKYIRGKINH--DIALLRLHRPVTFTDYVVPLCLPE---KSFSENTLARIRFSRVSGWGQ 327

  Fly  1241 REDKDPKSTYEYIVNEVQVPIITRNQCDEWLDNLT----VSEGMVCAGFDDGGKDACQGDSGGPL 1301
            ..|:...:..   :..::||.:....|.|...:.:    ::|.|.|||:.||.||||:||||||.
Mouse   328 LLDRGATALE---LMSIEVPRLMTQDCLEHAKHSSNTPKITENMFCAGYMDGTKDACKGDSGGPH 389

  Fly  1302 LCPYPGEKNRWFVGGIVSWGIMCAHPRLPGVYANVVQYVPWI 1343
            ...|.|   .|::.|:||||..||.....|||..|.||:.|:
Mouse   390 ATHYHG---TWYLTGVVSWGEGCAAIGHIGVYTRVSQYIDWL 428

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Corin	NP_610297.2	CRD_FZ	778..894	CDD:143549	2/5 (40%)
		LDLa	911..942	CDD:238060	10/35 (29%)
		LDLa	945..979	CDD:238060	7/42 (17%)
		SR	980..>1034	CDD:214555	1/53 (2%)
		Tryp_SPc	1104..1346	CDD:238113	80/257 (31%)
F7	NP_034302.2	GLA	24..85	CDD:214503	6/26 (23%)
		EGF_CA	87..123	CDD:238011	10/36 (28%)
		FXa_inhibition	132..168	CDD:464251	10/128 (8%)
		Tryp_SPc	194..431	CDD:238113	80/257 (31%)