Protein Alignment Corin and TMPRSS11B

DIOPT Version :10

• Sequence 1: NP_610297.2
• Gene: Corin / 35691
• FlyBaseID: FBgn0033192
• Length: 1397
• Species: Drosophila melanogaster
• Sequence 2: NP_872308.2
• Gene: TMPRSS11B / 132724
• HGNCID: 25398
• Length: 416
• Species: Homo sapiens
• Alignment Length: 322
• Identity: 105/322 - (32%)
• Similarity: 151/322 - (46%)
• Gaps: 27/322 - (8%)

  Fly  1031 NATSVLTQLTHR-PLLATVNVSTDIWKMYAKRKSTLMQEF-------ANCKKTEDYPMADLTCSN 1087
            |.::|..||..: |....|::.|   |:.||....|....       |:.|..|....|....:|
Human   107 NGSNVQLQLKFKFPPAEGVSMRT---KIKAKLHQMLKNNMASWNAVPASIKLMEISKAASEMLTN 168

  Fly  1088 YECGRVKRGRHKPSRRIIGGTQASPGNWPFLAAILGGPEKIFYCAGVLISDQWVLTASHCVGNYS 1152
            ..|||..........:|:.|..:..|.||:.|::..  :...||...|||.:|:|:|:||....:
Human   169 NCCGRQVANSIITGNKIVNGKSSLEGAWPWQASMQW--KGRHYCGASLISSRWLLSAAHCFAKKN 231

  Fly  1153 VIDLEDWTIQLGVTRRNSFTYSGQKVKVKAVIPHPQYNMAIAHDNDIALFQLATRVAFHEHLLPV 1217
              :.:|||:..|:.....:    ...||:.:|.|..|:....|| ||||.|||..|:|.|::..:
Human   232 --NSKDWTVNFGIVVNKPY----MTRKVQNIIFHENYSSPGLHD-DIALVQLAEEVSFTEYIRKI 289

  Fly  1218 CLPPPSVRNLHPGTLCTVIGWGKREDKDPKSTYEYIVNEVQVPIITRNQCD-EWLDNLTVSEGMV 1281
            |||...:: |.......|.|||...   ...::..|:.|..:.||....|: .:..:..|::.|:
Human   290 CLPEAKMK-LSENDNVVVTGWGTLY---MNGSFPVILQEDFLKIIDNKICNASYAYSGFVTDTML 350

  Fly  1282 CAGFDDGGKDACQGDSGGPLLCPYPGEKNRWFVGGIVSWGIMCAHPRLPGVYANVVQYVPWI 1343
            ||||..|..||||.||||||  .||..:|.|.:.||||||..|.....||||..|..|..||
Human   351 CAGFMSGEADACQNDSGGPL--AYPDSRNIWHLVGIVSWGDGCGKKNKPGVYTRVTSYRNWI 410

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Corin	NP_610297.2	CRD_FZ	778..894	CDD:143549
		LDLa	911..942	CDD:238060
		LDLa	945..979	CDD:238060
		SR	980..>1034	CDD:214555	1/2 (50%)
		Tryp_SPc	1104..1346	CDD:238113	86/241 (36%)
TMPRSS11B	NP_872308.2	SEA	45..142	CDD:460188	11/37 (30%)
		Tryp_SPc	185..413	CDD:238113	86/241 (36%)