DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Corin and Dmbt1

DIOPT Version :9

Sequence 1:	NP_610297.2	Gene:	Corin / 35691	FlyBaseID:	FBgn0033192	Length:	1397	Species:	Drosophila melanogaster
Sequence 2:	XP_006507361.2	Gene:	Dmbt1 / 12945	MGIID:	106210	Length:	2061	Species:	Mus musculus

Alignment Length:	827	Identity:	155/827 - (18%)
Similarity:	223/827 - (26%)	Gaps:	351/827 - (42%)

- Green bases have known domain annotations that are detailed below.

  Fly   427 EPSSVSASASTSSAASAGSSTISSGTMSSMSGPCPAVVPPTDAITKRPGPPEPPLRQANV--FDP 489
            |.:.|..|||.||:                  |.|.|..|||..|         ..|..|  :.|
Mouse   532 EDAGVICSASQSSS------------------PTPDVFYPTDQTT---------AEQTTVPDYTP 569

  Fly   490 VETGSRGHPPPPLTVRNKLGRNKPPPITYPRMQQRQD-------STLSSDSYSISSSPGYNSKLM 547
            :.|.|      .|.||...|.:        |.|.|.:       .|:..||:.::
Mouse   570 IGTDS------GLAVRLVNGGD--------RCQGRVEILYQGSWGTVCDDSWDLN---------- 610

  Fly   548 EAPLLGSQQG-GRKSNAPGSAQRQTPLMDLAPTRFLGGAGGGTGSGKQGPAMPPPRSKINFRQDS 611
            :|.::..|.| |...:|||||            ||    |.||     ||.:
Mouse   611 DANVVCRQLGCGLAVSAPGSA------------RF----GQGT-----GPIV------------- 641

  Fly   612 TISSDSFSQTSSPGYNPKLMEAPLLPSLS--------AKRLCSA-----PAPIVCRQGVQHEPIE 663
                  ....:..||...|........||        |..:|||     |.|.|      ..|.:
Mouse   642 ------MDDVACGGYEDYLWRCSHRGWLSHNCGHHEDAGVICSASQSSSPTPDV------FYPTD 694

  Fly   664 ELEPPQTISPLHKAAGQPSSLQTIVRFQNGAPHTMSLQHQIINRRKSSNPYITNGRLKFRLFQIL 728
            :....||..|.:...|..:||  .||.:||...
Mouse   695 QTTAEQTTVPDYTTIGTENSL--AVRLENGGDR-------------------------------- 725

  Fly   729 INAFALLAIAGGLAAYFNAYPTIKFVNKTIINTIHVEDTTSFGKNPAPGTCLPIIVRFCQGPQIP 793
                                                                      |||
Mouse   726 ----------------------------------------------------------CQG---- 728

  Fly   794 YNYTVFPNYIGHFGQLETQTDLDSYEALVDVRCYELVSLFLCTLFVPKCGQSGATVPPCKTLCTE 858
               .|...|.|.:|   |..| ||:    |:....:|           |.|.|
Mouse   729 ---RVEILYQGSWG---TVCD-DSW----DLNDANVV-----------CRQLG------------ 759

  Fly   859 TMRRCGFFFDVFGLSLPEYLNCKLFKDFPSSEDCVGLDEVREVMRAATHPKCDGFQCDQNRCLPQ 923
                ||     ..:|.|....      |......:.:|:|          .|.|::....||..:
Mouse   760 ----CG-----LAVSAPGSAR------FGQGTGPIVMDDV----------ACGGYEDYLWRCSHR 799

  Fly   924 EYV---CDGHLDCMDQADEAKCERCGPDEIYCGDSQCIGTKHICDGIIDCPYGQDERNCLRLSER 985
            .::   |..|.|.......::.....||..|..|...:....:.|   ..|.|.:....:|| |.
Mouse   800 GWLSHNCGHHEDAGVICSASQSSSPTPDVFYPTDQTTVEQTTVPD---YTPIGTENSLAVRL-EN 860

  Fly   986 NGDVGTGVLEVYRIGQRQWMPACVKNWDRAVSPSAVCSILGYS-AVNATSVLTQLTHRPLLATVN 1049
            .||...|.:|:  :.|..|...|..:|| ....:.||..||.. ||:|..              |
Mouse   861 GGDRCQGRVEI--LYQGSWGTVCDDSWD-TKDANVVCRQLGCGWAVSAPG--------------N 908

  Fly  1050 VSTDIWKMYAKRKSTLMQEFANCKKTEDYPMADLTCS-----NYECGRVKRGRHKPSRRIIGGTQ 1109
            .      .:.....:::.:...|...|||..   :||     ::.|     |.|:.:..|....|
Mouse   909 A------YFGPGSGSIVLDDVACTGHEDYLW---SCSHRGWLSHNC-----GHHEDAGVICSDAQ 959

  Fly  1110 ----ASPGNWPFLAAILGGPEKI------------------FYCAGVLISDQWVLTASHCVGNYS 1152
                ..|..||....    ||..                  :.|.|:|.......::.:...||.
Mouse   960 IQSTTRPDLWPTTTT----PETTTELLTTTPYFDWWTTTSDYSCGGLLTQPSGQFSSPYYPSNYP 1020

  Fly  1153 VIDLEDWTIQLGVTRRNSFTYS------GQKVKVKAVIPHPQYNMAI 1193
            ......|.|.|....|.:..::      |.......|...|:||.::
Mouse  1021 NNARCSWKIVLPNMNRVTVVFTDVQLEGGCNYDYILVYDGPEYNSSL 1067

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Corin	NP_610297.2	CRD_FZ	778..894	CDD:143549	21/115 (18%)
		LDLa	911..942	CDD:238060	6/33 (18%)
		LDLa	945..979	CDD:238060	7/33 (21%)
		SR	980..>1034	CDD:214555	19/54 (35%)
		SRCR	992..1086	CDD:278931	19/94 (20%)
		Tryp_SPc	1103..1343	CDD:214473	21/119 (18%)
		Tryp_SPc	1104..1346	CDD:238113	21/118 (18%)
Dmbt1	XP_006507361.2	SR	33..133	CDD:214555
		SR	152..252	CDD:214555
		SR	301..401	CDD:214555
		SR	439..539	CDD:214555	2/6 (33%)
		SR	578..678	CDD:214555	31/157 (20%)
		SR	717..817	CDD:214555	34/252 (13%)
		SR	856..956	CDD:214555	30/131 (23%)
		CUB	999..1107	CDD:238001	14/69 (20%)
		CUB	1115..1223	CDD:238001
		CUB	1241..1349	CDD:238001
		CUB	1357..1465	CDD:238001
		SR	1486..1585	CDD:214555
		CUB	1609..1717	CDD:238001
		ZP	1728..1975	CDD:214579
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	0	0.000