Protein Alignment Corin and LOC1281146

DIOPT Version :10

• Sequence 1: NP_610297.2
• Gene: Corin / 35691
• FlyBaseID: FBgn0033192
• Length: 1397
• Species: Drosophila melanogaster
• Sequence 2: XP_321085.5
• Gene: LOC1281146 / 1281146
• VectorBaseID: AGAMI1_012643
• Length: 2104
• Species: Anopheles gambiae
• Alignment Length: 1455
• Identity: 305/1455 - (20%)
• Similarity: 494/1455 - (33%)
• Gaps: 400/1455 - (27%)

  Fly    65 PSNSGSISESSSLSSSNSIVRRHSSHYYPMLEDKQKPSQLPQAATEMLVNMTEQKYC-------- 121
            |..:.....:|....|:|....||       |:|...|...:...:::|:.||::..
Mosquito   794 PEPTSEPEPASEPEPSSSTDADHS-------EEKSTESSTGKLLQQVIVSTTERETTIPTTTTTN 851

  Fly   122 -QSAHQGASIAGGRQVHHQQQHLVRVDTPVTPPPPIPRRLLRGKSAWQASSPH------------ 173
             |.:...:.:........|....:.||         ...:|:..|..::|:|:
Mosquito   852 GQRSSTSSLVPSTTDDDSQLPDFMFVD---------QESMLKHSSTIESSTPNVIVTVTEQSGKD 907

  Fly   174 --PLPLSAGGQDGAHGTGTGTVFVYPQPENVTAEAVVRGSGDGQGGGGAGLQSALLVDIATRPAS 236
              |.|::....|......|.:.||.|:|   |..|...||.                  :|...:
Mosquito   908 DTPAPVTETIVDDTPMPSTSSFFVPPKP---TTPATPAGSS------------------STTVVN 951

  Fly   237 GYADADGISDDDRMSLENSVFDESLTSTPVKVAGYLAGRYAGLSHMAKRAQRSSSSTVDSAYGSS 301
            |: :...:|.:|  :.:|:|:   .||:|:.:..:                |||:|
Mosquito   952 GF-EGRSLSSND--TADNTVY---ATSSPISLEQW----------------RSSTS--------- 985

  Fly   302 LGGHSERFASSSTSVDFRSRFSSVDTQSSLDEKPLSSSIDSPLARDPRDA--------------- 351
                   ||   ||.:...|.|.|..:::    |...||:|..||....|
Mosquito   986 -------FA---TSTEAFGRDSEVQDETN----PFLPSIESSSARSAPGAGSYAVTETVVEAETT 1036

  Fly   352 ------YRERAVLNDAMHKLNNNNTSLGLALYSASNNNNGSSVASDGSQLPVVPARKQPPPVKGS 410
                  :.|...|.:     ..||.||...|:...:.:.|..:.:....|.|||..|........
Mosquito  1037 APILAGHNESPFLPE-----TENNASLVKILHEGLDRHEGYEIETQPQYLEVVPLAKDGDRTDYK 1096

  Fly   411 SNSSNSIGET--QSQSSKEPSSVSASASTSSAASAGSSTISSGTMSSMSGPCPAVVPPTDAITKR 473
            ...:..:.||  .:.:.:.|..|:..:.....:.|.|..|...|.||..
Mosquito  1097 KQLNAHVTETIYITTTIRSPVPVTTESLEELLSVASSKNIVEQTTSSGE---------------- 1145

  Fly   474 PGPPEPPLRQANVFDPVETGSRGHPPPPLTVRNKLGRNKPPPITYPRMQQR------QDSTLSSD 532
                          :.|.|.:......|.|:                |:||      |.:|.:|:
Mosquito  1146 --------------EMVATSTEREMEEPTTM----------------MEQRTAKEASQSATTASE 1180

  Fly   533 SYSISSSP-GYNSKLMEAPLLGSQQGG---RKSNAPGSAQR---------------QTPLMDLAP 578
            :.:::.:. |..|......|:||....   ..||...|.:.               .||  :...
Mosquito  1181 NSTMAETALGATSSSTTEQLVGSVTEAMLTETSNMDDSTEMVMQTTTNEDVDQLAITTP--EEEQ 1243

  Fly   579 TRFLGGAGGGTGSGKQGPAMPPPRSKINFRQDSTISSDSFSQTSSPGYNPKLMEAPLLPSLSAKR 643
            |..|.....|.....|.....|..|..:....:|.::.:.:.|::|.       |....:.:...
Mosquito  1244 TTLLKAIDAGEKLQNQADETTPSSSSTSSSTTTTTTTTTTTTTTTPA-------ASTSTTTTTPA 1301

  Fly   644 LCSAPAPIVCRQGVQHEPIEELEPPQTISPLHKAAGQPSSLQTIVRFQNGAPHTMSLQHQIINRR 708
            ..:.|.|.|..:.:  :||..:|........:..|...:.|...:|.   .|         :|.:
Mosquito  1302 AATNPPPSVVTEAL--DPITAIEKDLISLKENDLADDNNLLDNDLRV---IP---------LNWK 1352

  Fly   709 KSSNPYITNGRLKFRLFQILINAFALLAIAGGLAAYFNAYPTI-------KFVNKTIINTIHVED 766
            |.::  .|..||...              :|..|:...:..|:       .|:::|..:.|..|.
Mosquito  1353 KDAS--TTTERLTVE--------------SGSPASSTESSATLIPTTTTGHFLDETTFHLIRSER 1401

  Fly   767 TTSFGKNPAPGTCLPIIVRFCQGPQIPYNYTVFPNYIGHFGQLETQTDLDSYEALV--------- 822
            :.        ||.| |..||.:                     |.:|..:...|:|
Mosquito  1402 SN--------GTSL-IGTRFSE---------------------ENETASEPAPAIVASSTPPATE 1436

  Fly   823 DVRCYELVSLFLCTLFVPKC--GQ----SGATVPPCKTLCTETMRRCGFFF---------DVFGL 872
            |.|...|:.....|:|. ||  ||    :|.::....: |.:...||....         |...|
Mosquito  1437 DTRMETLLLERASTMFT-KCAVGQFECINGTSIKDGSS-CIQKAERCDSVSHCSDNSDEQDCERL 1499

  Fly   873 SLPEYLNCKLFKDFPSSEDCVGL-------------------DEVREVMRAATHP------KCDG 912
            ..|.:..|:..........|.|:                   ||:.........|      ||||
Mosquito  1500 GCPGHFQCQDGVCLARQHVCDGIAHCHDGSDEQGCSEWRCNFDELSCNPATGNGPCLPALWKCDG 1564

  Fly   913 F-QC---------------------DQNRCLPQEYVCDGHLDCMDQADEAKCERCGPDEIYCGDS 955
            . ||                     .|.:|:|:.:.|||.:||.|..||..|: |..|...|...
Mosquito  1565 LEQCANGFDESNCPDTCTNDEYFCAGQRKCIPEAWRCDGAIDCSDGEDERLCD-CPLDSFKCHTG 1628

  Fly   956 QCIGTKHICDGIIDCPYGQDERNCLRLSERNGDVGTGVLEVYRIGQRQWMPACVKNWDRAVSPSA 1020
            .|:...::|||...||.|.||.:|.:|     |...|.|.|.| ...:.:..|...|:.|:: ..
Mosquito  1629 GCVVGAYVCDGHAQCPDGSDEWHCYQL-----DRADGALRVKR-NSSEALAVCGDGWNGALA-DM 1686

  Fly  1021 VCSILGYSAVNATSVLTQLTHRPLLATVNVSTDIWKMY-AKRKSTLMQEFANCKKTEDYPMADLT 1084
            ||:.|||:  .|:.:|.........:|.|.|. :..|| ...|:.|  ||......|......|.
Mosquito  1687 VCAELGYA--GASKILFTKVGSGGGSTGNGSL-VDSMYRVTEKNRL--EFEPIHSMECNQGLQLY 1746

  Fly  1085 CSNYECGRVKRGRHKPS--RRIIGGTQASPGNWPFLAAILGGPEKIFYCAGVLISDQWVLTASHC 1147
            |..|.||   |.|.:|:  :||.||..:.|..||.||........| .|...::|.:|.|.:..|
Mosquito  1747 CEEYRCG---RERIQPTLEQRIAGGVASDPNQWPSLALAFSNNAAI-KCTASIVSPRWALASYTC 1807

  Fly  1148 -------VGNYSVIDLEDWTIQLGV---------TRRNSFTYSGQKVKVKAVIPHPQ--YNMAIA 1194
                   |.|.:|.|: .|.:..|.         |...|...|.|.|.||.|:|:||  |.. ..
Mosquito  1808 IMGKTEFVNNRNVGDM-SWKLFAGSALFNASLEDTAAASADASYQIVDVKRVVPYPQSKYKQ-FM 1870

  Fly  1195 HDNDIALFQLATRVAFHEHLLPVCLPPPSVRNLHPGTLCTVIGWGKREDKDPKSTYEYIVNEVQV 1259
            :..|:||.:|:..:..::.:..|||  ....::....||...|||  .|.:..:|.|..:..:.|
Mosquito  1871 YTGDVALLELSAPLKLNDMVGSVCL--AEAASIDSEQLCLTAGWG--SDLENTATTEQYLKYLPV 1931

  Fly  1260 PIITRNQCDEWLD-NLTVSEGMVCAGFDDGGKDACQGDSGGPLLCPYPGEKNRWFVGGIVSWGIM 1323
            |.:...:|:..:. |..:.|..:||||.:..|..|..|.|.||:| |.....:|.:.||:|:...
Mosquito  1932 PTVPTERCNSSIHYNGVLPENAICAGFLNSNKTTCYNDEGAPLMC-YLDGSGQWQLEGILSYHGN 1995

  Fly  1324 CAHPRLPGVYANVVQYV-PWIQEQI 1347
            |.....|.:|.::...: .||:..:
Mosquito  1996 CGKRPHPAIYNSITSNISTWIRNTV 2020

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Corin	NP_610297.2	CRD_FZ	778..894	CDD:143549	27/139 (19%)
		LDLa	911..942	CDD:238060	15/52 (29%)
		LDLa	945..979	CDD:238060	12/33 (36%)
		SR	980..>1034	CDD:214555	15/53 (28%)
		Tryp_SPc	1104..1346	CDD:238113	73/261 (28%)
LOC1281146	XP_321085.5	None