Protein Alignment Corin and flz

DIOPT Version :10

• Sequence 1: NP_610297.2
• Gene: Corin / 35691
• FlyBaseID: FBgn0033192
• Length: 1397
• Species: Drosophila melanogaster
• Sequence 2: XP_061514180.1
• Gene: flz / 1279956
• VectorBaseID: AGAMI1_007310
• Length: 1401
• Species: Anopheles gambiae
• Alignment Length: 1495
• Identity: 301/1495 - (20%)
• Similarity: 492/1495 - (32%)
• Gaps: 465/1495 - (31%)

  Fly    94 MLEDKQKPSQLPQAATEMLVNMTEQKYCQSAHQGASIAGGRQVHHQQQHLVRVDTPVTPPPPIPR 158
            ::|......|..|::....:....:|:      |:.::||   .:.:..:|:::    ..||.|.
Mosquito   122 LMEQANATEQTGQSSLSSAIASQYEKF------GSQVSGG---GYGEGVVVQME----QDPPKPD 173

  Fly   159 RLLRGKS-AWQASSPHPLPLSAGGQDGAHGTGTGTVFVYPQPENVTAEAVVRGSGDGQGGGGAGL 222
            ......| .:.|:|....||....|:..          |...:::..:.|:...|
Mosquito   174 SYETDTSGGYMATSEKIKPLYQKIQNNN----------YIVNDDLDEDIVLNSIG---------- 218

  Fly   223 QSALLVDIATRPASGYADADGISDDDRMSLENSVFDESLTSTPVKVAGYLAGRYAGLSHMAK--- 284
              |...|:|:...|.|:.:           .|.:..||....|....||.:...:..:|..:
Mosquito   219 --ANKYDVASDAVSVYSPS-----------TNKIKTESEELPPSSSLGYPSTTESDETHYVQVNK 270

  Fly   285 -RAQRSSSSTVDSAYGSSLGGHSERFASSSTSVDFRSRFSSVDTQSSLDEKPLSSS-------ID 341
             ....:...::.||||.:..|.|...:||:.|.:..:..::...|...::....:|       |.
Mosquito   271 DGVYSAEIPSLLSAYGETSSGESSGPSSSAISTETSTDITATGVQQIANQIFQENSQFFDHSDIT 335

  Fly   342 SPLARDPRDAYRERAVLNDAMHKLNNNNTSLGLALYSASNNNNGSSVASDGSQLPVVPA------ 400
            .|.|        |..:||:  |         |....|.:|.|:.|.|......:|..||
Mosquito   336 HPAA--------ETDLLNE--H---------GTVDQSYANPNDFSGVPQASQSVPQPPAPTVKPA 381

  Fly   401 ---------RKQPPPVKGSSNSSNS--------IGETQSQSSKEP-------------------S 429
                     :.:|.|.:.|||.|.|        ..:|::.:..:|                   |
Mosquito   382 KVTYPKPQFKPRPKPTQPSSNESGSQYVLVQTISNDTKNDTQAKPTVSMNNIPSIESIILMLNDS 446

  Fly   430 SVSASASTSSAASAGSSTISSGTMSSMSG----------------------PCPAV------VPP 466
            :|.....|...|:|..:|..:.|:.|..|                      ..|.|      ||.
Mosquito   447 NVGPQYETDDGANATKATFEASTVPSTYGTAAIDYDKYGPTSFYITKPQKTEAPTVTHTTSNVPS 511

  Fly   467 TDAI-----TKRPGPPEPPLRQANVFDPVETGSRG------------HPPPPLTVRNKLGRNKPP 514
            |..:     |||| ..||.:.||.:.......|.|            |.|||..:......:|.|
Mosquito   512 TSYVYSPKPTKRP-TLEPVVVQATLLTNSAVASYGGSQQNDPQPSSTHRPPPTKIIVTASTSKRP 575

  Fly   515 PI---------------TYP--------------------------------------RMQQRQD 526
            .:               |.|                                      .:..:..
Mosquito   576 VLITTDTLASAGYYTGPTRPASTVAVSSVQPTKKITTIATKRPIATTIKLPEYIVQSSTLSHQNP 640

  Fly   527 STLSSDSY----SISSSPGYNSKLMEAPLLG--------SQQGGRKSNAPGSAQ----RQTP--- 572
            |||::.:|    |.|.:|.....:...|::|        |......|.||||::    ..||
Mosquito   641 STLANVNYIQIASASDNPSPTVHITPKPVVGLVTSSTWNSNNKLGSSVAPGSSRPGFYENTPPVY 705

  Fly   573 ---LMDLAPTRFLGGAG-----GGTGSGKQGPAMPPPRSKINFRQDSTISSDSFSQTSSPGYNPK 629
               :.|.....:.|...     .|..|......:....:||:....||.:  .:..|:|.|..|.
Mosquito   706 LSSMADFEDEGYFGSTSRPALDNGVTSTSIYTIVDSNNNKISNFASSTYA--PYGPTASYGSTPS 768

  Fly   630 --LMEAPLLPSLSAKRLCSAPAPI---VCRQGVQHEPIEELEPPQTISPLHKAAGQPSSLQTIVR 689
              :...|..|||   :....|:|:   ..:..:...|.:....|...:| :......:::..|.:
Mosquito   769 YPIRVPPNQPSL---QTYGPPSPVEVSTLKNELYTTPDDINNFPPVRNP-NLNLTDATTMSNITK 829

  Fly   690 FQNGAPHTMSLQHQIINRRKSSNPYITNGRLKFRLFQILINA--FALLAIAGGLAAYFNAYPTIK 752
            .::|...|.:.:...:|...:......||.|: .|.|||.:.  ..:.:.||.|||...:.|:
Mosquito   830 IESGLYGTPASEEDKVNMLVNKIVQSFNGNLE-ELEQILKDRRNLTVTSTAGALAATTESTPS-- 891

  Fly   753 FVNKTIINTIHVEDTTSFGK--------NPAPGTCLPIIVRFCQGPQIPYNYTVFPNYIGHFGQL 809
            .|:.|...:.....||:..|        |..|............|.:.|   |..|
Mosquito   892 SVSSTSEGSTPTSSTTAKPKKKKKRPSGNKKPSNATTTSSSSSSGTKKP---TAKP--------- 944

  Fly   810 ETQTDLDSYEALVDVRCYELVSLFLCTLFVPKCGQSGATVPPCKTLCTE--TMRRCGFFFDVFGL 872
                                      |:.......:|.:|.|......:  .:||..........
Mosquito   945 --------------------------TVLADSATSTGTSVKPSSRPSKKPTKVRRPSNSTKPTSA 983

  Fly   873 SLP---EYLNCKLFKDFPSSEDCVGLDEVREVMRAATHPKCDGFQCDQNRCLPQEYVCDGHLDCM 934
            |.|   ..|:..:..|.|          |:....::|.||
Mosquito   984 SKPTSATTLSKPIASDTP----------VKPAKPSSTKPK------------------------- 1013

  Fly   935 DQADEAKCERCGPDEIYCGDSQCIGTKHICDGIIDCPYGQDERNCLRLSERNGDVGTGVLEVYRI 999
             .:..|...|..|.         ..||....|      |...:..:|.|
Mosquito  1014 -PSTAATSTRPKPS---------TATKPSTSG------GSTTKKPVRTS---------------- 1046

  Fly  1000 GQRQWMPACVKNWDRAVS--PSAVCSILGYSAVNATSVLTQLTHRPLLATVNVSTDIWKMYAKRK 1062
                   ...|...|..|  |:...:.|..:.:..|...|::|.||.....:.:|   ...|..:
Mosquito  1047 -------TSTKRPTRKPSTRPTLADADLTTTQLTTTRKPTKVTKRPTKRPTSTTT---STTAAPE 1101

  Fly  1063 STLMQEFANC-------KKTEDYPMAD---LTCSNYECGRVKRGR-----HKP---SRRIIGGTQ 1109
            ...:.|..|.       ::.||..:.:   .|..:...|    ||     .:|   |.|::||..
Mosquito  1102 DETIDEEENAVDGEDGEEEEEDEDVGEEQNETADHQHAG----GRKILCGQRPLMKSGRVVGGKA 1162

  Fly  1110 ASPGNWPFLAAI-----LGGPEKIF---YCAGVLISDQWVLTASHC--------VGNYSVIDL-E 1157
            :..|.||:...:     ||    :|   .|.||||::::|:||:||        |..:...|: .
Mosquito  1163 SKFGEWPWQVLVRESTWLG----LFTKNKCGGVLITNEYVITAAHCQPGFLASLVAVFGEFDISS 1223

  Fly  1158 DWTIQLGVTRRNSFTYSGQKVKVKAVIPHPQYNMAIAHDNDIALFQLATRVAFHEHLLPVCLPPP 1222
            |...:..||:           .||.||.|.||: |...:||:|:.:|...:.:..|::|:|:|..
Mosquito  1224 DLETKRSVTK-----------NVKRVIVHRQYD-AATFENDLAILELENPIHYDVHIVPICMPGD 1276

  Fly  1223 SVRNLHPGTLCTVIGWGKREDKDPKSTY----EYIVNEVQVPIITRNQCDEWL----DNLTVSEG 1279
            ...  ..|.:.||.|||       :.||    ..::.|||||:|..:.|.|..    .|..:...
Mosquito  1277 EAD--FTGRMATVTGWG-------RLTYGGGVPSVLQEVQVPVIENSVCQEMFHMAGHNKKILPS 1332

  Fly  1280 MVCAGFDDGGKDACQGDSGGPLLCPYPGEKNRWFVGGIVSWGIMCAHPRLPGVYANVVQYVPWIQ 1344
            .||||:.:|.:|:|:|||||||:...|  ..|:.:.|.||.||.||.|.|||||.....|.||::
Mosquito  1333 FVCAGYANGKRDSCEGDSGGPLVLQRP--DGRYELVGTVSHGIRCAAPYLPGVYMRTTFYKPWLR 1395

  Fly  1345  1344
            Mosquito  1396  1395

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Corin	NP_610297.2	CRD_FZ	778..894	CDD:143549	15/120 (13%)
		LDLa	911..942	CDD:238060	1/30 (3%)
		LDLa	945..979	CDD:238060	5/33 (15%)
		SR	980..>1034	CDD:214555	7/55 (13%)
		Tryp_SPc	1104..1346	CDD:238113	88/266 (33%)
flz	XP_061514180.1	None