DRSC/TRiP Functional Genomics Resources

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Protein Alignment Corin and St14

DIOPT Version :10

Sequence 1:NP_610297.2 Gene:Corin / 35691 FlyBaseID:FBgn0033192 Length:1397 Species:Drosophila melanogaster
Sequence 2:NP_446087.1 Gene:St14 / 114093 RGDID:69288 Length:855 Species:Rattus norvegicus


Alignment Length:506 Identity:147/506 - (29%)
Similarity:212/506 - (41%) Gaps:127/506 - (25%)


- Green bases have known domain annotations that are detailed below.


  Fly   874 LPEYLNCKLFKDFPSSEDCVGLDEVREVMRAATHPKCDGFQCDQNRCLPQEYVCDGHLDCMDQAD 938
            |.|||:      :.|::.|.|:                 |.|...||:.::..|||..||.|.:|
  Rat   441 LAEYLS------YDSNDPCPGM-----------------FMCKTGRCIRKDLRCDGWADCPDYSD 482

  Fly   939 EAKCERCGPDEIYCGDSQCIGTKHICDGIIDCPYGQDER--------------NCLRLSER-NG- 987
            |..|......:..|.:..|.....:||.:.||..|.||.              .||..|:: || 
  Rat   483 ERHCRCNATHQFMCKNQFCKPLFWVCDSVNDCGDGSDEEGCSCPAGSFKCSNGKCLPQSQQCNGK 547

  Fly   988 -DVGTGVLEVYRIGQRQWMPACVKNWDRAVSPSAVCSILGYSAVNATSVLTQLTHRPLLATVNVS 1051
             |.|.|                        |..|.|     ..|||.| .|:.|:|         
  Rat   548 DDCGDG------------------------SDEASC-----DNVNAVS-CTKYTYR--------- 573

  Fly  1052 TDIWKMYAKRKSTLMQEFANCKKTEDYPMADLTCS------NYECGRVKRGRHKPSRRIIGGTQA 1110
                   .:....|.:....|...:|       ||      |.:||  .|...|.: |::|||.|
  Rat   574 -------CQNGLCLNKGNPECDGKKD-------CSDGSDEKNCDCG--LRSFTKQA-RVVGGTNA 621

  Fly  1111 SPGNWPFLAAI--LGGPEKIFYCAGVLISDQWVLTASHCVGNYSVIDLED---WTIQLGVTRRNS 1170
            ..|.||:..::  ||   :...|...|||..|:::|:||..:.::....|   ||..||:..::.
  Rat   622 DEGEWPWQVSLHALG---QGHLCGASLISPDWLVSAAHCFQDETIFKYSDHTMWTAFLGLLDQSK 683

  Fly  1171 FTYSG-QKVKVKAVIPHPQYNMAIAHDNDIALFQLATRVAFHEHLLPVCLPPPSVRNLH---PGT 1231
            .:.|| |:.|:|.:|.||.:| ....|.||||.:|.....:...:.|:|||.    |.|   .|.
  Rat   684 RSASGVQEHKLKRIITHPSFN-DFTFDYDIALLELEKPAEYSTVVRPICLPD----NTHVFPAGK 743

  Fly  1232 LCTVIGWGKREDKDPKSTYEYIVNEVQVPIITRNQCDEWLDNLTVSEGMVCAGFDDGGKDACQGD 1296
            ...|.|||..::   ..|...|:.:.::.:|.:..|:|.|.. .::..|:|.||..||.|:||||
  Rat   744 AIWVTGWGHTKE---GGTGALILQKGEIRVINQTTCEELLPQ-QITPRMMCVGFLSGGVDSCQGD 804

  Fly  1297 SGGPLLCPYPGEKN-RWFVGGIVSWGIMCAHPRLPGVYANVVQYVPWIQEQ 1346
            |||||...   ||: |.|..|:||||..||....||||..:.:...||:||
  Rat   805 SGGPLSSV---EKDGRIFQAGVVSWGEGCAQRNKPGVYTRIPEVRDWIKEQ 852

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
CorinNP_610297.2 CRD_FZ 778..894 CDD:143549 6/19 (32%)
LDLa 911..942 CDD:238060 12/30 (40%)
LDLa 945..979 CDD:238060 9/47 (19%)
SR 980..>1034 CDD:214555 13/56 (23%)
Tryp_SPc 1104..1346 CDD:238113 87/251 (35%)
St14NP_446087.1 SEA 88..178 CDD:460188
CUB 214..332 CDD:238001
CUB 340..444 CDD:238001 1/2 (50%)
LDLa 454..486 CDD:238060 13/48 (27%)
LDLa 492..523 CDD:238060 9/30 (30%)
LDLa 525..559 CDD:238060 10/57 (18%)
LDLa 567..602 CDD:238060 8/57 (14%)
Tryp_SPc 615..852 CDD:238113 87/251 (35%)
Blue background indicates that the domain is not in the aligned region.

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