Protein Alignment Corin and KLK8

DIOPT Version :10

• Sequence 1: NP_610297.2
• Gene: Corin / 35691
• FlyBaseID: FBgn0033192
• Length: 1397
• Species: Drosophila melanogaster
• Sequence 2: NP_653088.1
• Gene: KLK8 / 11202
• HGNCID: 6369
• Length: 305
• Species: Homo sapiens
• Alignment Length: 360
• Identity: 102/360 - (28%)
• Similarity: 153/360 - (42%)
• Gaps: 82/360 - (22%)

  Fly  1006 PACVKNWDRAVSPSAVCSILG--YSAVNATSVLTQLTHRPLLATVNVSTDIWKMYAKRKSTLMQE 1068
            |...|.|       ....:||  ::|..:..:||                  |:||
Human     6 PRAAKTW-------MFLLLLGGAWAACGSLDLLT------------------KLYA--------- 36

  Fly  1069 FANCKKTEDYPMADLT----CSNYECGRVKRGRHKP-----SR----RIIGGTQASPGNWPFLAA 1120
                   |:.|...|.    .....|.|..|....|     ||    :::||.:..|.:.|:.||
Human    37 -------ENLPCVHLNPQWPSQPSHCPRGWRSNPLPPAAGHSRAQEDKVLGGHECQPHSQPWQAA 94

  Fly  1121 ILGGPEKIFYCAGVLISDQWVLTASHCVGNYSVIDLEDWTIQLGVTRRNSFTYSGQKVKVKAVIP 1185
            :..|.:.:  |.|||:...|||||:||       ....:|::||.....:.....|::.|...||
Human    95 LFQGQQLL--CGGVLVGGNWVLTAAHC-------KKPKYTVRLGDHSLQNKDGPEQEIPVVQSIP 150

  Fly  1186 HPQYNMAIA--HDNDIALFQLATRVAFHEHLLPVCLPPPSVRNLHPGTLCTVIGWGKREDKDPKS 1248
            ||.||.:..  |::|:.|.||..:.:....:.|:.|.....:   ||..|||.|||  ....|:.
Human   151 HPCYNSSDVEDHNHDLMLLQLRDQASLGSKVKPISLADHCTQ---PGQKCTVSGWG--TVTSPRE 210

  Fly  1249 TYEYIVNEVQVPIITRNQCDEWLDNLTVSEGMVCAGFDDGGKDACQGDSGGPLLCPYPGEKNRWF 1313
            .:...:|..:|.|..:.:|::.... .:::|||||| ...|.|.|||||||||:|.       ..
Human   211 NFPDTLNCAEVKIFPQKKCEDAYPG-QITDGMVCAG-SSKGADTCQGDSGGPLVCD-------GA 266

  Fly  1314 VGGIVSWGI-MCAHPRLPGVYANVVQYVPWIQEQI 1347
            :.||.|||. .|.....||||.|:.:|:.||::.|
Human   267 LQGITSWGSDPCGRSDKPGVYTNICRYLDWIKKII 301

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Corin	NP_610297.2	CRD_FZ	778..894	CDD:143549
		LDLa	911..942	CDD:238060
		LDLa	945..979	CDD:238060
		SR	980..>1034	CDD:214555	6/29 (21%)
		Tryp_SPc	1104..1346	CDD:238113	81/244 (33%)
KLK8	NP_653088.1	Tryp_SPc	77..297	CDD:214473	79/242 (33%)