Protein Alignment Corin and PRSS21

DIOPT Version :10

• Sequence 1: NP_610297.2
• Gene: Corin / 35691
• FlyBaseID: FBgn0033192
• Length: 1397
• Species: Drosophila melanogaster
• Sequence 2: NP_006790.1
• Gene: PRSS21 / 10942
• HGNCID: 9485
• Length: 314
• Species: Homo sapiens
• Alignment Length: 303
• Identity: 107/303 - (35%)
• Similarity: 149/303 - (49%)
• Gaps: 44/303 - (14%)

  Fly  1070 ANCKKTEDYPMADLT--CSNYECGRVKRGRHKPSRRIIGGTQASPGNWPFLAAILGGPEKIFYCA 1132
            |..:|.|....|.|:  |          ||...:.||:||..|..|.||:..::......:  |.
Human    16 AGLRKPESQEAAPLSGPC----------GRRVITSRIVGGEDAELGRWPWQGSLRLWDSHV--CG 68

  Fly  1133 GVLISDQWVLTASHCVGNYSVIDLED---WTIQLG-VTRRNSFTYSGQ----KVKVKAVIPHPQY 1189
            ..|:|.:|.|||:||...||  ||.|   |.:|.| :|...|| :|.|    :..|..:...|:|
Human    69 VSLLSHRWALTAAHCFETYS--DLSDPSGWMVQFGQLTSMPSF-WSLQAYYTRYFVSNIYLSPRY 130

  Fly  1190 --NMAIAHDNDIALFQLATRVAFHEHLLPVCLPPPSVRNLHPGTLCTVIGWGK-REDKDPKSTYE 1251
              |...    ||||.:|:..|.:.:|:.|:|| ..|.......|.|.|.|||. :||:...|  .
Human   131 LGNSPY----DIALVKLSAPVTYTKHIQPICL-QASTFEFENRTDCWVTGWGYIKEDEALPS--P 188

  Fly  1252 YIVNEVQVPIITRNQCD----EWLDNLTVSEGMVCAGFDDGGKDACQGDSGGPLLCPYPGEKNRW 1312
            :.:.||||.||..:.|:    ::.....:...|||||...||||||.|||||||.|   .:...|
Human   189 HTLQEVQVAIINNSMCNHLFLKYSFRKDIFGDMVCAGNAQGGKDACFGDSGGPLAC---NKNGLW 250

  Fly  1313 FVGGIVSWGIMCAHPRLPGVYANVVQYVPWIQEQIAKH--SRP 1353
            :..|:||||:.|..|..||||.|:..:..|||:.:|:.  |:|
Human   251 YQIGVVSWGVGCGRPNRPGVYTNISHHFEWIQKLMAQSGMSQP 293

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Corin	NP_610297.2	CRD_FZ	778..894	CDD:143549
		LDLa	911..942	CDD:238060
		LDLa	945..979	CDD:238060
		SR	980..>1034	CDD:214555
		Tryp_SPc	1104..1346	CDD:238113	95/256 (37%)
PRSS21	NP_006790.1	Tryp_SPc	42..283	CDD:238113	94/255 (37%)