DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Corin and MASP2

DIOPT Version :9

Sequence 1:	NP_610297.2	Gene:	Corin / 35691	FlyBaseID:	FBgn0033192	Length:	1397	Species:	Drosophila melanogaster
Sequence 2:	NP_006601.2	Gene:	MASP2 / 10747	HGNCID:	6902	Length:	686	Species:	Homo sapiens

Alignment Length:	724	Identity:	183/724 - (25%)
Similarity:	258/724 - (35%)	Gaps:	222/724 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly   789 GPQIP---YNYTVFPNYIGHFGQLE----TQTDLDSYEALVDVRCYELVSLFLCTLFVPKCGQSG 846
            ||:.|   :.....|.:.|.:...:    |.|....|...:....::|....||.....|. .||
Human    19 GPKWPEPVFGRLASPGFPGEYANDQERRWTLTAPPGYRLRLYFTHFDLELSHLCEYDFVKL-SSG 82

  Fly   847 ATVPPCKTLC----TETMRRCGFFFDVF---GLSL-----PEYLNCKLFKDFPSSEDCVGLDEVR 899
            |.|  ..|||    |:|.|..|  .|.|   |.||     .:|.|.|.|..|.:......:||.:
Human    83 AKV--LATLCGQESTDTERAPG--KDTFYSLGSSLDITFRSDYSNEKPFTGFEAFYAAEDIDECQ 143

  Fly   900 EVMRAATHPKCD--------GFQC----------DQNRCLPQEYVCDGH---------------- 930
            .....|  |.||        ||.|          ::..|   ..:|.|.
Human   144 VAPGEA--PTCDHHCHNHLGGFYCSCRAGYVLHRNKRTC---SALCSGQVFTQRSGELSSPEYPR 203

  Fly   931 ---------------------LDCMDQAD-----EAKC-----------ERCGPDEIYCGDS--Q 956
                                 ||.::..|     |..|           |..||   :||.:  .
Human   204 PYPKLSSCTYSISLEEGFSVILDFVESFDVETHPETLCPYDFLKIQTDREEHGP---FCGKTLPH 265

  Fly   957 CIGTK---------------------HICDGIIDCPYGQDERNCLRLSERNGDVG---------- 990
            .|.||                     |.......|||        .::..||.|.
Human   266 RIETKSNTVTITFVTDESGDHTGWKIHYTSTAQPCPY--------PMAPPNGHVSPVQAKYILKD 322

  Fly   991 -------TGVLEVYRIGQ-----RQWMPACVK--NWDRAVSPSAVCSILGYS------------- 1028
                   ||    |.:.|     :.:...|.|  :|||   |...|||:...
Human   323 SFSIFCETG----YELLQGHLPLKSFTAVCQKDGSWDR---PMPACSIVDCGPPDDLPSGRVEYI 380

  Fly  1029 ---AVNATSVLTQLTHRPLLATVNVSTDIWKMYAKRKSTLMQEFANCKKTEDYPMADLTCSNYEC 1090
               .|.....:.|.:......|:.|:...:...|....|      :.|..:..|:.:..|.  ..
Human   381 TGPGVTTYKAVIQYSCEETFYTMKVNDGKYVCEADGFWT------SSKGEKSLPVCEPVCG--LS 437

  Fly  1091 GRVKRGRHKPSRRIIGGTQASPGNWPFLAAILGGPEKIFYCAGVLISDQWVLTASHCV----GNY 1151
            .|...|      ||.||.:|.||::|:...||||..    .||.|:.|.|||||:|.|    .:.
Human   438 ARTTGG------RIYGGQKAKPGDFPWQVLILGGTT----AAGALLYDNWVLTAAHAVYEQKHDA 492

  Fly  1152 SVIDLEDWTIQLGVTRRNSFTYSGQKVKVKAVIPHPQYNMAIAHDNDIALFQLATRVAFHEHLLP 1216
            |.:|     |::|..:|.|..|:  :...:||..|..|......||||||.:|..:|..:.::.|
Human   493 SALD-----IRMGTLKRLSPHYT--QAWSEAVFIHEGYTHDAGFDNDIALIKLNNKVVINSNITP 550

  Fly  1217 VCLPPPSVRN-LHPGTLCTVIGWGKREDKDPKSTYEYIVNEVQVPIITRNQCDEWLDNL-----T 1275
            :|||.....: :....:.|..|||..:.........|    |.:||:...:|....:..     :
Human   551 ICLPRKEAESFMRTDDIGTASGWGLTQRGFLARNLMY----VDIPIVDHQKCTAAYEKPPYPRGS 611

  Fly  1276 VSEGMVCAGFDDGGKDACQGDSGGPLLCPYPGEKNRWFVGGIVSWGIM-CAHPRLPGVYANVVQY 1339
            |:..|:|||.:.||||:|:|||||.|:. ...|..|||||||||||.| |......|||..|:.|
Human   612 VTANMLCAGLESGGKDSCRGDSGGALVF-LDSETERWFVGGIVSWGSMNCGEAGQYGVYTKVINY 675

  Fly  1340 VPWIQEQIA 1348
            :|||:..|:
Human   676 IPWIENIIS 684

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Corin	NP_610297.2	CRD_FZ	778..894	CDD:143549	33/123 (27%)
		LDLa	911..942	CDD:238060	11/90 (12%)
		LDLa	945..979	CDD:238060	11/56 (20%)
		SR	980..>1034	CDD:214555	17/93 (18%)
		SRCR	992..1086	CDD:278931	20/116 (17%)
		Tryp_SPc	1103..1343	CDD:214473	91/250 (36%)
		Tryp_SPc	1104..1346	CDD:238113	92/252 (37%)
MASP2	NP_006601.2	CUB	28..134	CDD:214483	30/110 (27%)
		EGF_CA	138..176	CDD:214542	9/39 (23%)
		CUB	184..293	CDD:278839	15/111 (14%)
		CCP	300..361	CDD:214478	16/75 (21%)
		Sushi	366..430	CDD:278512	8/69 (12%)
		Tryp_SPc	444..679	CDD:214473	91/250 (36%)
		Tryp_SPc	445..682	CDD:238113	92/252 (37%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910