DRSC/TRiP Functional Genomics Resources

powered by:
logo

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Corin and CORIN

DIOPT Version :9

Sequence 1:NP_610297.2 Gene:Corin / 35691 FlyBaseID:FBgn0033192 Length:1397 Species:Drosophila melanogaster
Sequence 2:NP_006578.2 Gene:CORIN / 10699 HGNCID:19012 Length:1042 Species:Homo sapiens


Alignment Length:610 Identity:197/610 - (32%)
Similarity:294/610 - (48%) Gaps:71/610 - (11%)


- Green bases have known domain annotations that are detailed below.


  Fly   779 CLPIIVRFCQGPQIPYNYTVFPNYIGHFGQLETQTDLDS--YEALVDVRCYELVSLFLCTLFVPK 841
            |.||.:..|.  .:|||.|.:|||.||..|.|.....:|  :.|||...||:.:..|.||:.|||
Human   455 CEPITLELCM--NLPYNSTSYPNYFGHRTQKEASISWESSLFPALVQTNCYKYLMFFSCTILVPK 517

  Fly   842 CG-QSGATVPPCKTLCTETMRRCGFFFDVFGLSLPEYLNCKLFKDFPS-SEDCVGLDEVREVMRA 904
            |. .:|..:|||:.||..:..||.....:.||..||..:|..|.:..| ::.|:..||..|.. :
Human   518 CDVNTGEHIPPCRALCEHSKERCESVLGIVGLQWPEDTDCSQFPEENSDNQTCLMPDEYVEEC-S 581

  Fly   905 ATHPK------------CDG--------------------FQCDQNR-CLPQEYVCDGHLDCMDQ 936
            .:|.|            |||                    ::|..|: ||....:|||..||.|.
Human   582 PSHFKCRSGQCVLASRRCDGQADCDDDSDEENCGCKERDLWECPSNKQCLKHTVICDGFPDCPDY 646

  Fly   937 ADEAKCERCGPDEIYCGDSQCIGTKHICDGIIDCPYGQDERNCLRLSERNGDVGTGVLEVYRIGQ 1001
            .||..|..|..||:.|.:..|:.....|||..||....||.:|:.||....  .:..|.|:|...
Human   647 MDEKNCSFCQDDELECANHACVSRDLWCDGEADCSDSSDEWDCVTLSINVN--SSSFLMVHRAAT 709

  Fly  1002 RQWMPACVKNWDRAVSPSAVCSILGYSAVNATSVLTQLTHRPLLATVNVSTDIWKMYAKRKSTLM 1066
            ...:  |...|...:|..| |..:|....:.|.::.:....|...|::.:   |:  :...:||.
Human   710 EHHV--CADGWQEILSQLA-CKQMGLGEPSVTKLIQEQEKEPRWLTLHSN---WE--SLNGTTLH 766

  Fly  1067 QEFANCKKTEDYPMADLTCSNYECGRVKRGRHKPSRRIIGGTQASPGNWPFLAAILGGPEKIFYC 1131
            :...|.:..|......|.|:..:|||  |...:.::||:||..:.||.||:..::...|.. ..|
Human   767 ELLVNGQSCESRSKISLLCTKQDCGR--RPAARMNKRILGGRTSRPGRWPWQCSLQSEPSG-HIC 828

  Fly  1132 AGVLISDQWVLTASHCV---GNYSVIDLEDWTIQLGVTRRNSFTYSGQKVKVKAVIPHPQYNMAI 1193
            ..|||:.:||||.:||.   .|.:|     |.:.||:...:..:...|...||.:|.||:|:.|:
Human   829 GCVLIAKKWVLTVAHCFEGRENAAV-----WKVVLGINNLDHPSVFMQTRFVKTIILHPRYSRAV 888

  Fly  1194 AHDNDIALFQLATRVAFHEHLLPVCLPPPSVRNLHPGTLCTVIGWGKREDKDPKSTYEYIVNEVQ 1258
            . |.||::.:|:..::...::.|||||.|. :.|.|.|.|.:.|||...:|.|     :.:.|.:
Human   889 V-DYDISIVELSEDISETGYVRPVCLPNPE-QWLEPDTYCYITGWGHMGNKMP-----FKLQEGE 946

  Fly  1259 VPIITRNQCDEWLDNLTVSEGMVCAGFDDGGKDACQGDSGGPLLCPYPGEKNRWFVGGIVSWGIM 1323
            |.||:...|..:.|..|::..|:|||::.|..|:|.|||||||:|..||  .||.:.|:.|||.:
Human   947 VRIISLEHCQSYFDMKTITTRMICAGYESGTVDSCMGDSGGPLVCEKPG--GRWTLFGLTSWGSV 1009

  Fly  1324 CAHPRL-PGVYANVVQYVPWIQEQI 1347
            |....| ||||:||..:|.||:.||
Human  1010 CFSKVLGPGVYSNVSYFVEWIKRQI 1034

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
CorinNP_610297.2 CRD_FZ 778..894 CDD:143549 44/118 (37%)
LDLa 911..942 CDD:238060 14/51 (27%)
LDLa 945..979 CDD:238060 12/33 (36%)
SR 980..>1034 CDD:214555 11/53 (21%)
SRCR 992..1086 CDD:278931 18/93 (19%)
Tryp_SPc 1103..1343 CDD:214473 90/243 (37%)
Tryp_SPc 1104..1346 CDD:238113 91/245 (37%)
CORINNP_006578.2 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..25
DDNN motif 26..29
CRD_corin_1 135..263 CDD:143554
LDLa 269..304 CDD:238060
LDLa 306..340 CDD:238060
Ldl_recept_a 347..377 CDD:278486
LDLa 387..414 CDD:238060
CRD_corin_2 454..575 CDD:143579 44/121 (36%)
LDLa 580..614 CDD:238060 5/34 (15%)
LDLa 655..689 CDD:238060 12/33 (36%)
SR 690..786 CDD:214555 20/105 (19%)
Tryp_SPc 801..1030 CDD:214473 90/243 (37%)
Tryp_SPc 802..1033 CDD:238113 91/245 (37%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_KOG3577
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 1 1.000 - - FOG0007867
OrthoInspector 1 1.000 - - oto91114
orthoMCL 1 0.900 - - OOG6_107940
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 1 1.030 - avgDist Average_Evolutionary_Distance R11034
SonicParanoid 1 1.000 - - X4386
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
76.740

Return to query results.
Submit another query.