DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Corin and Prss50

DIOPT Version :9

Sequence 1:	NP_610297.2	Gene:	Corin / 35691	FlyBaseID:	FBgn0033192	Length:	1397	Species:	Drosophila melanogaster
Sequence 2:	XP_017451624.2	Gene:	Prss50 / 100910205	RGDID:	6499372	Length:	424	Species:	Rattus norvegicus

Alignment Length:	399	Identity:	94/399 - (23%)
Similarity:	157/399 - (39%)	Gaps:	96/399 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly   979 CLRLSERNGDVGTGVLEVYRIGQRQWMPACVKNWDRAVSPSAVCSILG--------YSAVNATSV 1035
            ||...|....:.|.|                     ...|.|.|:..|        ....:.||.
  Rat    66 CLAAGESPATLSTAV---------------------PTGPRASCASSGICPSGRLRLPRQDQTSD 109

  Fly  1036 LTQLTHRP----LLATVNVSTDIWKMYAKRKSTLMQEFANCKKTEDYPMADLTCSNYECGRVKRG 1096
            .:|.|..|    .|:||.::..:.|                .|..:.|:         ||..:
  Rat   110 TSQTTTPPKGMGALSTVGITGSVSK----------------TKPGNLPL---------CGSSQ-- 147

  Fly  1097 RHKPSRRIIGGTQASPGNWPFLAAILGGPEKIFYCAGVLISDQWVLTASHCVGNYSVIDLEDWTI 1161
            ...|:.|   ..:|....||::.::......:  |||:||:.||||..:||:....|    ::|:
  Rat   148 EPDPTLR---DPEAMTRRWPWMVSVQTNGSHV--CAGILIASQWVLAVAHCLSQNRV----NYTV 203

  Fly  1162 QLGVTRRNSFTYSGQKVKVKAVIPHPQYNMA-----IAHDNDIALFQLATRVAFHEHLLPVCLPP 1221
            ::|....|..|.:...|.|..||.:..|...     :...:||.|.:|...:.:.:::.|||||.
  Rat   204 RVGSPWINQTTETSSDVPVNQVIINSGYQSKRYWSWVGRIHDIGLLKLKWGLKYSKYVWPVCLPG 268

  Fly  1222 PSVRNLHPGTLCTVIGWGKREDKDPKSTYEY----IVNEVQVPIITRNQCDEWLDNLT------- 1275
            ... .:..|:||||.|||.     ||:...:    .:.|.:|.|:...:|:.:....:
  Rat   269 LEY-VVEDGSLCTVTGWGY-----PKANGLWPQFQTLQEKEVSILNSRECEHYYHKFSRIHSLVR 327

  Fly  1276 -VSEGMVCAGFDDGGKDACQGDSGGPLLCPYPGEKNRWFVGGIVSWGIMCAHPRLPGVYANVVQY 1339
             :|..|:|| .|:..:..|...||.||:|...|   .|::.|::|||..|.....|.::..|..|
  Rat   328 IISPQMICA-LDNDREKFCYERSGEPLVCSSDG---MWYLVGVMSWGPGCKKSEAPPIFLQVSHY 388

  Fly  1340 VPWIQEQIA 1348
            ..||.::::
  Rat   389 QLWIWDRLS 397

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Corin	NP_610297.2	CRD_FZ	778..894	CDD:143549
		LDLa	911..942	CDD:238060
		LDLa	945..979	CDD:238060	94/399 (24%)
		SR	980..>1034	CDD:214555	8/61 (13%)
		SRCR	992..1086	CDD:278931	16/105 (15%)
		Tryp_SPc	1103..1343	CDD:214473	69/256 (27%)
		Tryp_SPc	1104..1346	CDD:238113	70/258 (27%)
Prss50	XP_017451624.2	Tryp_SPc	162..392	CDD:238113	67/245 (27%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24253
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	2	2.100