DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Corin and fzd4

DIOPT Version :9

Sequence 1:	NP_610297.2	Gene:	Corin / 35691	FlyBaseID:	FBgn0033192	Length:	1397	Species:	Drosophila melanogaster
Sequence 2:	XP_002936589.1	Gene:	fzd4 / 100497693	XenbaseID:	XB-GENE-478210	Length:	523	Species:	Xenopus tropicalis

Alignment Length:	310	Identity:	76/310 - (24%)
Similarity:	115/310 - (37%)	Gaps:	88/310 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly   779 CLPIIVRFCQGPQIPYNYTVFPNYIGHFGQLETQTDLDSYEALVDVRCYELVSLFLCTLFVPKCG 843
            |.||.:..||  .:.||.|..||.:||..|.:.:..|.::..|:...|...:..|||:::||.|.
Frog    31 CDPIRISMCQ--NLGYNVTKMPNLVGHELQADAELQLTTFTPLIQYGCSSQLQFFLCSVYVPMCT 93

  Fly   844 QS-GATVPPCKTLCTETMRRCGFFFDVFGLSLPEYLNCKLFKDFPSSED----CV---GLDEVRE 900
            :. ...:.||..:|....|||......||.:.||.|||   ..||...|    |:   |.|||
Frog    94 EKINIPIGPCGGMCLSVKRRCEPVLKEFGFAWPESLNC---SKFPPQNDHNHMCMEGPGDDEV-- 153

  Fly   901 VMRAATHPKCDGFQCDQNRCLPQEYVCDGHLDCMDQADEAKCERCGPDEIYCGDSQCIGTKHICD 965
                ..|.|        ...||.|                .|...||:     ..|....|...:
Frog   154 ----PVHSK--------TPVLPGE----------------DCNSFGPN-----SDQYTWVKRSMN 185

  Fly   966 GIIDCPYGQDERNCLRLSERNGDVGTGVLEVYRIGQRQWMPACVKNWDRAVSPSAVCSILGYSAV 1030
            .::.|  |.|.....|||:...|:              ||..    |      :::|.|     .
Frog   186 CVLKC--GYDSGLYSRLSKEFTDI--------------WMAV----W------ASLCFI-----S 219

  Fly  1031 NATSVLTQL--------THRPLLATVNVSTDIWKMYAKRKSTLMQEFANC 1072
            .|.:|||.|        ..||:: .:::..:|:.:....:.|:.:|..:|
Frog   220 TAFTVLTFLIDSSRFCYPERPII-FLSMCYNIYSIAYIVRLTVGRERISC 268

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Corin	NP_610297.2	CRD_FZ	778..894	CDD:143549	39/122 (32%)
		LDLa	911..942	CDD:238060	3/30 (10%)
		LDLa	945..979	CDD:238060	7/33 (21%)
		SR	980..>1034	CDD:214555	10/53 (19%)
		SRCR	992..1086	CDD:278931	16/89 (18%)
		Tryp_SPc	1103..1343	CDD:214473
		Tryp_SPc	1104..1346	CDD:238113
fzd4	XP_002936589.1	CRD_FZ4	28..153	CDD:143557	41/126 (33%)
		7tmF_FZD4	195..495	CDD:320166	20/104 (19%)
		TM helix 1	204..229	CDD:320166	10/53 (19%)
		TM helix 2	238..259	CDD:320166	3/21 (14%)
		TM helix 3	289..315	CDD:320166
		TM helix 4	332..348	CDD:320166
		TM helix 5	370..399	CDD:320166
		TM helix 6	419..446	CDD:320166
		TM helix 7	456..481	CDD:320166
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910