Protein Alignment Corin and f12

DIOPT Version :10

• Sequence 1: NP_610297.2
• Gene: Corin / 35691
• FlyBaseID: FBgn0033192
• Length: 1397
• Species: Drosophila melanogaster
• Sequence 2: XP_017947702.2
• Gene: f12 / 100493769
• XenbaseID: XB-GENE-1004811
• Length: 597
• Species: Xenopus tropicalis
• Alignment Length: 638
• Identity: 158/638 - (24%)
• Similarity: 228/638 - (35%)
• Gaps: 202/638 - (31%)

  Fly   840 PKCGQSGATVPPCKTLCTETMRRCGFFFDVFGLSL-----------PEYLNCKLFKDFPSSED-- 891
            ||.|.          :.||:.:.|.|.|. :|..|           |... |.|.|::...:.
 Frog    33 PKSGY----------VLTESGQLCHFPFQ-YGRMLHNSCIKIGKHGPRKW-CSLTKNYDRDQSWS 85

  Fly   892 -CVGLDEVREVMRAATHPKCDGFQCDQNRCLPQEYVCDGHLDCMDQADEAKCERCGPDEIY---- 951
             ||...||.:             .|:.:.|.|:. ||:..|         |...|...|.|
 Frog    86 YCVEGHEVHD-------------HCENDPCKPRG-VCESTL---------KGYHCVCKEPYTGKH 127

  Fly   952 CGDSQCIGTKHICDGIIDCPYGQDERNCLRLS----ERNGDVGTGV---------------LEVY 997
            |...:|...|.:       .|...:...||.|    |:.|....||               |...
 Frog   128 CQTDKCFDKKSL-------QYFNPKDEWLRYSPPVLEKCGCTEKGVVCKQTHGMACSKNLCLHGG 185

  Fly   998 RIGQRQWMPACVKNWDRAVSPSAV---CSI-----------LGYSAVNATSV------------- 1035
            |..|...|.||      ..||..:   |.|           :||.....|:|
 Frog   186 RCIQHNKMTAC------GCSPGFIGTHCEIHQKETCYTGNGIGYRGTGNTTVSGAPCLHWDSDII 244

  Fly  1036 -------------LTQLTHRPLLATVNVSTDIWKMYAKRKSTLMQE---FANC------------ 1072
                         :..:...|.....:..|..| .:..::..|..|   ...|
 Frog   245 EHEVSMYGGHRGKVHGIDSHPYCRNPDGDTQPW-CFVMKEQRLSWEHCLIPRCTQLAGTTAPPKV 308

  Fly  1073 ------KKTEDYPMADLTCSN-------------YECGRVKRGRHKPS--RRIIGGTQASPGNWP 1116
                  .|:.::..:..:.||             .:|||  :.:..||  .||:||..|.|.:.|
 Frog   309 TKTPSPTKSSNHSASTPSPSNDTQGPVDGRIDLPVDCGR--KFQKTPSIMPRIVGGLVALPASHP 371

  Fly  1117 FLAAILGGPEKIFYCAGVLISDQWVLTASHCVG---NYSVIDLEDWTIQLGVTRRNSFTYSGQKV 1178
            ::||:.....   :|.|.|||..|::||:||:.   |.:.|     ::.||.:|.|:.......:
 Frog   372 YIAALYIDNH---FCGGSLISPCWIVTAAHCLDQRPNVTKI-----SVVLGQSRFNTTDQHTVTL 428

  Fly  1179 KVKAVIPHPQ-YNMAIAHDNDIALFQLAT-----RVAFHEHLLPVCLPPPSVRNLHPGTLCTVIG 1237
            .|:..|.|.: |...:.|  ||||.::.:     ...|.:.:.|:|| |...:.......|.|.|
 Frog   429 LVEKYILHEKYYGDTLQH--DIALVKVKSINGLCASEFSQFVQPICL-PQQFKMAESTKQCVVAG 490

  Fly  1238 WGKREDKDPKSTYEYIVNEVQVPIITRNQC-------DEWLDNLTVSEGMVCAGFDDGGKDACQG 1295
            ||  ...:....|.:.:.|..:|||...||       |..|      .||:||||.:||.|||||
 Frog   491 WG--HQYEGAEHYAFFLQEASMPIIPYTQCQSPSVHGDRML------PGMLCAGFMEGGVDACQG 547

  Fly  1296 DSGGPLLCPYPGEKNRWFVGGIVSWGIMCAHPRLPGVYANVVQYVPWIQEQIA 1348
            ||||||:|...|   |..:.|:||||..||....||||..|..|..||:..|:
 Frog   548 DSGGPLVCEVDG---RIELHGVVSWGSGCAEENKPGVYTAVTSYTDWIRANIS 597

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Corin	NP_610297.2	CRD_FZ	778..894	CDD:143549	15/67 (22%)
		LDLa	911..942	CDD:238060	6/30 (20%)
		LDLa	945..979	CDD:238060	7/37 (19%)
		SR	980..>1034	CDD:214555	19/86 (22%)
		Tryp_SPc	1104..1346	CDD:238113	89/257 (35%)
f12	XP_017947702.2	FN2	40..87	CDD:238019	11/48 (23%)
		EGF_CA	95..129	CDD:238011	10/56 (18%)
		KR	213..298	CDD:214527	10/85 (12%)
		Tryp_SPc	359..595	CDD:238113	89/257 (35%)