Protein Alignment Corin and tmprss2.2

DIOPT Version :10

• Sequence 1: NP_610297.2
• Gene: Corin / 35691
• FlyBaseID: FBgn0033192
• Length: 1397
• Species: Drosophila melanogaster
• Sequence 2: XP_002941330.2
• Gene: tmprss2.2 / 100493729
• XenbaseID: XB-GENE-22065949
• Length: 521
• Species: Xenopus tropicalis
• Alignment Length: 539
• Identity: 164/539 - (30%)
• Similarity: 232/539 - (43%)
• Gaps: 92/539 - (17%)

  Fly   844 QSGATV--PPCKTLCTETMRR--CGFFFDVFGLSLPEYLNCKLFKDFPSSEDCVGLDEVREVMRA 904
            |||..|  ||. |..|.|.||  |...|.|.         ||:.......  .:|....:.....
 Frog    44 QSGQFVARPPI-TPSTGTRRRRICIISFIVI---------CKVAAIVAGL--IIGFVVTKRPSTT 96

  Fly   905 ATHPKCDGFQCDQNRCLPQEYVCDGHLDCMDQADEAKCERCGPD--EIYCGDS-QCIGTKHICDG 966
            .:.|.|..:......|:....:|||..||....||..|....|.  |..||.| .|:.:...|||
 Frog    97 PSTPTCQMYCSYTYTCIHAYQICDGVQDCRYGDDERNCGATLPANCEKRCGSSVSCVRSSQWCDG 161

  Fly   967 IIDCPYGQDERNCLRLSERNGDVGTGVLEVYRIGQRQWMPACVKNWDRAVSPSAVCSILGYSAVN 1031
            :..||.|:||.:|:||...:..     |:||...:..|:|.|..||..|....| |...|||.
 Frog   162 VSQCPNGEDETSCVRLYGADSQ-----LQVYSTLKSAWLPVCADNWSDAYGRFA-CRDFGYSG-- 218

  Fly  1032 ATSVLTQLTHRPLLATVNVSTDIWKMYA-------------KRKSTLMQEFANCKKTEDYPMADL 1083
                          ::.|.|..:...||             .:..|.:|..::|....   :..|
 Frog   219 --------------SSYNRSNTLPSPYAPNGYFKLNNGFGSSQFYTSVQNSSSCFSGN---VVSL 266

  Fly  1084 TCSNYECGRVKRGRHKPSRRIIGGTQASPGNW------PFLAAILGGPEKIFYCAGVLISDQWVL 1142
            .|  ..||   ...:..:.||:|||.|:.|||      .:...||        |.|.:||.:|::
 Frog   267 RC--ISCG---VSYNSVASRIVGGTYAAYGNWLWQVGLRYNTGIL--------CGGSIISPKWIV 318

  Fly  1143 TASHCVGNYS----VIDLEDWTIQLGVTRRNSFTYSGQKVKVKAVIPHPQYNMAIAHDNDIALFQ 1203
            ||:|||  |.    ::....|.:..|.....|: |......|:.:||||.|..: ::||||||.:
 Frog   319 TAAHCV--YGTDGFLLSASGWRVFAGTLTLPSY-YDSSGYLVERIIPHPGYKTS-SNDNDIALME 379

  Fly  1204 LATRVAFHEHLLPVCLPPPSVRNLHPGTLCTVIGWGKREDKDPKSTYEYIVNEVQVPIITRNQCD 1268
            |:..:.|..:..|||||...: ....||.|.:.|||........|||   :....|.:|..|.|:
 Frog   380 LSNGITFGYNTQPVCLPNAGM-FWSSGTPCWISGWGTTSQGGSASTY---LQYAAVQLIDSNVCN 440

  Fly  1269 E-WLDNLTVSEGMVCAGFDDGGKDACQGDSGGPLLCPYPGEKNRWFVGGIVSWGIMCAHPRLPGV 1332
            : ::.|..::..|:|||:..||.|:|||||||||:....|   .|::.|..|||..||.|..|||
 Frog   441 QNYVYNGQITASMICAGYLSGGVDSCQGDSGGPLVTKTNG---TWWLVGDTSWGYGCAQPNKPGV 502

  Fly  1333 YANVVQYVPWIQEQIAKHS 1351
            |.|:..::.||..|:..||
 Frog   503 YGNMTSFLGWIYLQMRTHS 521

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Corin	NP_610297.2	CRD_FZ	778..894	CDD:143549	16/53 (30%)
		LDLa	911..942	CDD:238060	8/30 (27%)
		LDLa	945..979	CDD:238060	14/36 (39%)
		SR	980..>1034	CDD:214555	16/53 (30%)
		Tryp_SPc	1104..1346	CDD:238113	90/252 (36%)
tmprss2.2	XP_002941330.2	LDLa	<111..134	CDD:238060	8/22 (36%)
		LDLa	145..174	CDD:238060	12/28 (43%)
		SRCR_2	179..274	CDD:464747	25/124 (20%)
		Tryp_SPc	282..513	CDD:238113	88/249 (35%)