DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Corin and corin

DIOPT Version :9

Sequence 1:	NP_610297.2	Gene:	Corin / 35691	FlyBaseID:	FBgn0033192	Length:	1397	Species:	Drosophila melanogaster
Sequence 2:	XP_004911266.2	Gene:	corin / 100492163	XenbaseID:	XB-GENE-950958	Length:	1123	Species:	Xenopus tropicalis

Alignment Length:	613	Identity:	201/613 - (32%)
Similarity:	303/613 - (49%)	Gaps:	67/613 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly   779 CLPIIVRFCQGPQIPYNYTVFPNYIGHFGQLETQTDLDS--YEALVDVRCYELVSLFLCTLFVPK 841
            |.||.:..|  ..:|||||.||||:||..|.|.....:|  :.|||...||:.:..|.||:.|||
Frog   534 CEPITLELC--INLPYNYTTFPNYLGHRTQKEASISWESSLFPALVQTNCYKYLMYFACTILVPK 596

  Fly   842 C-GQSGATVPPCKTLCTETMRRCGFFFDVFGLSLPEYLNCKLFKDFPS-SEDCVGLDE-VREVMR 903
            | .::...:|||::||..:..||.....:.||..||..:|..|.|..| ::.|:..|| |.|.
Frog   597 CEPETHQRIPPCRSLCEHSKERCESVLGIVGLQWPEDTDCTQFPDEKSDNQTCLMPDEDVEEC-- 659

  Fly   904 AATHPK------------CDG--------------------FQCDQNR-CLPQEYVCDGHLDCMD 935
            :.:|.|            |||                    ::|..|: |:....:|||..||.:
Frog   660 SPSHYKCRSGRCILASRRCDGEADCEDDSDEENCECAERGLWECPVNKMCIKHSMICDGFPDCPE 724

  Fly   936 QADEAKCERCGPDEIYCGDSQCIGTKHICDGIIDCPYGQDERNCLRLSERNGDVGTGVLEVYRIG 1000
            :.:|..|..|..:|:.|.:.:|:.....|||:|||..|.||.||:.||:....:  ..|.::|..
Frog   725 ELEEKNCSSCTSEELECANHECVSRDRWCDGLIDCTDGSDEWNCVTLSKSVSSL--TFLTIHRSA 787

  Fly  1001 QRQWMPACVKNWDRAVSPSAVCSILGYSAVNATSVLTQLTHRPLLATVNVSTDIWKMYAKRKSTL 1065
            ....:  |..:|:..:: ..||:.||....:.|:..|:|.|......:::..| ||  .:..||.
Frog   788 SDYHV--CADDWEEELT-QWVCNQLGLGGPSITAEATELDHFGHNEWLHLKED-WK--KQNGSTF 846

  Fly  1066 MQEFANCKKTEDYPMADLTCSNYECGRVKRGRHKPSRRIIGGTQASPGNWPFLAAILGGPEKIFY 1130
            .:.....:..|......|.|:..:|||  |...:.|:||:||..:.||.||:..::...|.. ..
Frog   847 HELLIKGQPCESRRKVSLLCTKEDCGR--RPAARMSKRILGGRTSRPGRWPWQCSLQSDPSG-HI 908

  Fly  1131 CAGVLISDQWVLTASHCV-GNYSVIDLEDWTIQLGVTRRNSFTYSGQKVKVKAVIPHPQYNMAIA 1194
            |..|||..:||||.:||. |..|.   ..|.:..|:...:..:...|...||.:|.||:||.|:.
Frog   909 CGCVLIGKKWVLTVAHCFEGRESA---AVWKVVFGINNLDHPSDFAQTRLVKKIILHPRYNRAVV 970

  Fly  1195 HDNDIALFQLATRVAFHEHLLPVCLPPPSVRNLHPGTLCTVIGWGKREDKDPKSTYEYIVNEVQV 1259
             |.||::.:|...:....::.|||||... :.:.|.|.|.:.|||...:|.|     :.:.|.:|
Frog   971 -DYDISIVELNEDITETSYVRPVCLPTKG-QLVEPDTYCYITGWGHMGNKMP-----FKLQEGEV 1028

  Fly  1260 PIITRNQCDEWLDNLTVSEGMVCAGFDDGGKDACQGDSGGPLLCPYPGEKNRWFVGGIVSWGIMC 1324
            .||:..:|..:.|..|::..|:|||::.|..|:|.|||||||:|..||.|  |.:.|:.|||.:|
Frog  1029 RIISLERCQSYFDMKTITSRMLCAGYESGTIDSCMGDSGGPLVCEKPGGK--WTLYGLTSWGSVC 1091

  Fly  1325 AHPRL-PGVYANVVQYVPWIQEQIAKHS 1351
            ....| ||||:||..:|.||:.||..||
Frog  1092 FSKVLGPGVYSNVSHFVEWIERQIYIHS 1119

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Corin	NP_610297.2	CRD_FZ	778..894	CDD:143549	46/118 (39%)
		LDLa	911..942	CDD:238060	11/51 (22%)
		LDLa	945..979	CDD:238060	13/33 (39%)
		SR	980..>1034	CDD:214555	10/53 (19%)
		SRCR	992..1086	CDD:278931	19/93 (20%)
		Tryp_SPc	1103..1343	CDD:214473	88/241 (37%)
		Tryp_SPc	1104..1346	CDD:238113	89/243 (37%)
corin	XP_004911266.2	CRD_corin_1	213..341	CDD:143554
		LDLa	351..382	CDD:238060
		LDLa	384..418	CDD:238060
		LDLa	420..455	CDD:238060
		LDLa	465..492	CDD:238060
		CRD_corin_2	533..654	CDD:143579	46/121 (38%)
		LDLa	659..693	CDD:238060	5/35 (14%)
		LDLa	734..768	CDD:238060	13/33 (39%)
		Tryp_SPc	883..1114	CDD:238113	89/243 (37%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0007867
OrthoInspector	1	1.000	-	-		oto104893
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X4386
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	4	3.910