Protein Alignment Corin and tmprss15

DIOPT Version :10

• Sequence 1: NP_610297.2
• Gene: Corin / 35691
• FlyBaseID: FBgn0033192
• Length: 1397
• Species: Drosophila melanogaster
• Sequence 2: XP_031752048.1
• Gene: tmprss15 / 100490249
• XenbaseID: XB-GENE-999987
• Length: 994
• Species: Xenopus tropicalis
• Alignment Length: 1192
• Identity: 252/1192 - (21%)
• Similarity: 420/1192 - (35%)
• Gaps: 362/1192 - (30%)

  Fly   290 SSSTVDSAYGSSLGGHSERFASSSTSVDFRSRFSSVDTQSSLDEKPLSSSIDSPLARDPRDAYRE 354
            :.|||...:..:.|........:.:||||::  .:.|.|..:.|...:..:.|.........:|.
 Frog    30 NESTVSGTFTIASGAEFTPSLQNQSSVDFKT--LAFDVQQLIYEIFQAGLLKSVYKSCQVLEFRN 92

  Fly   355 RAVLNDAMHKLN------NNNTSLGLALYSASNN---------NNGSSVASDGSQL----PVVPA 400
            .:|:  .:.||:      |.|....|.|...:||         :|.:.|.:|..::    |....
 Frog    93 GSVI--VLFKLHFTQITANENIHQELVLGIEANNADINKKFFIDNTTIVIADAQEMATTSPSTTL 155

  Fly   401 RKQPPPVKGSSNSSNSIGETQ--SQSSKEPSSVSASASTSSAASAGSSTIS--SGTMSSMSGP-- 459
            |:.||..:..::||..|.||:  ...|..|..........|....|...:|  |||..|.:.|
 Frog   156 RQCPPDERICADSSFCIQETRFCDGLSDCPDGSDEHEKFCSTPCDGQFFLSEASGTFHSKNYPQL 220

  Fly   460 ------CPAVVPPTDAITKRPGPPEPPLRQANVFDPVETGSRGHPPPPLTVRNKLGRNKPPPITY 518
                  |..::...|..:.:             ||
 Frog   221 YDPNLSCRWIISVRDGYSIK-------------FD------------------------------ 242

  Fly   519 PRMQQRQDSTLSSDSYSISSSPGYNSKLMEAPLLGSQQGGRKSNAPGSAQRQTPLMDLAPTRFLG 583
               .|..|:...||...|....|.| |::.|.|.|:.        ||:.:   ...:.|...|:.
 Frog   243 ---FQSFDTEEFSDVLDIYEGIGPN-KILRASLWGTN--------PGTVR---IFSNQATAEFIT 292

  Fly   584 GAGGGTGSGK-----------------------------------------QGPAMPPPRSKINF 607
            .........|                                         .||..||....
 Frog   293 DYSNNHNGFKAIYGTFLSDNVTNEEKINCNFEDGFCYWFQEIQDYDGWERVHGPTYPPTSGP--- 354

  Fly   608 RQDSTISSDSFSQTSSPGY--NPKLMEAPLLPSLSAKRLCSAPAPIVCRQGVQHEPIEELEPPQT 670
            .:|.|..:.|       ||  .|.:...|.:  |.:.||.|.             |::|...|..
 Frog   355 NEDHTFGNSS-------GYYLTPGIQVIPGI--LKSVRLLSL-------------PLKENSVPLC 397

  Fly   671 ISPLHKAAG-QPSSLQTIVRFQNGAPHTMSLQHQIINRRKSSNPYITNGRLKFRLFQILINAFAL 734
            :|..:...| ....|.....|.|      |.:..|..:..:..|....|::             .
 Frog   398 LSFWYHMYGVNVYRLNVFNIFAN------STETIIFQKEGNYGPSWNYGQV-------------T 443

  Fly   735 LAIAGGLAAYFNAYPTIKFVNKTIINTIHVEDTTSFGKNPAPGTC-------------LP---II 783
            |:...|....|.|....:|      ..|.::|...|     ||:|             :|   ::
 Frog   444 LSETSGTVVAFEAIQNQRF------GDIAIDDIGLF-----PGSCNESGFPEPTRVPTVPTTALL 497

  Fly   784 VRFCQGP-------------QIPYNYTVFPN------YI----GHFGQLETQT-DLDSYEALVDV 824
            ...|.||             ..|.||   ||      |:    |...||..|. :|::...:|::
 Frog   498 PSDCGGPTELWEPNVTFHSANYPQNY---PNLASCVWYLNAAPGKNIQLHFQVFNLENIYDVVEI 559

  Fly   825 RCYELVSLFLCTLFVPKCGQSGATVPPCKTLCTETMRRCGFFFDVFGLSLPEYLNCKLFKDFPSS 889
            |........|..::      :|:.  |.|.:.:.|.....:|                      :
 Frog   560 RDGRGPDSLLLAVY------TGSA--PVKDVFSTTSAMSVYF----------------------T 594

  Fly   890 EDCVG-----LDEVREVMRAATHPKCD--GFQCDQNRCLPQEYVCDGHLDCMDQADEAKCERCGP 947
            .|..|     |......:|......|:  .|||....|:|...|||.|.||.|
 Frog   595 SDSTGTAKGFLANYTTGLRLGMPEPCNSTSFQCGSGECIPNTAVCDKHRDCDD------------ 647

  Fly   948 DEIYCGDSQCIGTKHICDGIIDCPYGQDERNCLRL--SERNGDVGTGVLEVYRIGQRQWMPACVK 1010
                                     |.|||:|:||  |..:|      |..::: |.:|..||:.
 Frog   648 -------------------------GTDERHCVRLFNSSMSG------LVQFKV-QSEWHTACID 680

  Fly  1011 NWDRAVSPSAVCSILGYSAVNATSVLTQLTHRPLLATVNVSTDIWKMYAKRKSTLMQEFANCKKT 1075
            :|:..:| :.:|..||...||.||.:....:.|.:..:.|......:...      .:.||
 Frog   681 HWNEDIS-NDICHRLGLGNVNLTSAVLSEGNGPFVTLIQVEDGSLSLLPS------DQCAN---- 734

  Fly  1076 EDYPMADLTCSNYECGR----VKRGRHKPSRRIIGGTQASPGNWPFLAAILGGPEKIFY-----C 1131
              ..:..:.|...|||:    :|.|     .:|:||:.|:.|.||::.:       ::|     |
 Frog   735 --QSVIHIQCQQRECGKRLVPIKSG-----SKIVGGSDAALGAWPWIVS-------LYYNDRQTC 785

  Fly  1132 AGVLISDQWVLTASHCVGNYSVIDLEDWTIQLGVTRRNSFTYSGQKVK-VKAVIPHPQYNMAIAH 1195
            ...|::.:|:::|:|||...::|. .:|..:||:....:.|......: :..::.:||||.. ..
 Frog   786 GASLVNQEWLVSAAHCVYGRNLIP-SNWKARLGLHTNLNLTQPQIATQMIDQIVINPQYNRR-TK 848

  Fly  1196 DNDIALFQLATRVAFHEHLLPVCLPPPSVRNLHPGTLCTVIGWGKREDKDPKSTYEYIVNEVQVP 1260
            |:||.:..|..:|.:.:::.|:|||... :....|..|::.|||:.:...|...   |:.|.::|
 Frog   849 DSDIVMMHLQFKVNYSDYIQPICLPETD-QEFSVGINCSIAGWGRTQSGGPVPN---ILQEAEIP 909

  Fly  1261 IITRNQCDEWLDNLTVSEGMVCAGFDDGGKDACQGDSGGPLLCPYPGEKNRWFVGGIVSWGIMCA 1325
            :|:.::|.:.:....:::.|||.|:::||.|.||||||||::|.   :.|.||:.|:.|:|..||
 Frog   910 LISNHKCQQQMPEYNITDNMVCGGYEEGGIDTCQGDSGGPMMCQ---QNNEWFLVGVTSFGYGCA 971

  Fly  1326 HPRLPGVYANVVQYVPWIQEQI 1347
            .|..||||..|.::..||:..|
 Frog   972 QPSRPGVYVRVTEFTNWIKSFI 993

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Corin	NP_610297.2	CRD_FZ	778..894	CDD:143549	25/155 (16%)
		LDLa	911..942	CDD:238060	12/32 (38%)
		LDLa	945..979	CDD:238060	4/33 (12%)
		SR	980..>1034	CDD:214555	16/55 (29%)
		Tryp_SPc	1104..1346	CDD:238113	76/247 (31%)
tmprss15	XP_031752048.1	SEA	34..>103	CDD:460188	14/72 (19%)
		LDLa	157..190	CDD:197566	9/32 (28%)
		CUB	199..305	CDD:238001	27/163 (17%)
		MAM	321..478	CDD:459878	37/211 (18%)
		CUB	501..608	CDD:395345	25/139 (18%)
		LDLa	620..654	CDD:238060	17/70 (24%)
		SR	655..746	CDD:214555	23/110 (21%)
		Tryp_SPc	760..991	CDD:238113	76/246 (31%)