DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Corin and Tmprss12

DIOPT Version :9

Sequence 1:	NP_610297.2	Gene:	Corin / 35691	FlyBaseID:	FBgn0033192	Length:	1397	Species:	Drosophila melanogaster
Sequence 2:	XP_038936305.1	Gene:	Tmprss12 / 100362912	RGDID:	2323781	Length:	427	Species:	Rattus norvegicus

Alignment Length:	380	Identity:	115/380 - (30%)
Similarity:	163/380 - (42%)	Gaps:	81/380 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly  1010 KNW----DRAVSPSAVCSILGYSAVNATSVLTQLTHRPLLATVNVSTDIWKMYAKRKSTLMQEFA 1070
            |.|    .||..|:|  :|||.:|...:..|:    ..||.......     |.|..|..::|.:
  Rat    66 KRWRTSRHRADLPAA--AILGPAAAMGSWALS----AALLCLGGALA-----YGKLHSLTLREGS 119

  Fly  1071 NCKK---------TEDYPMADLTCSNYECGRVK-RGRHKPSRRIIGGTQASPGNWPFLAA--ILG 1123
            :..:         .|:.|:..      .||... ||..:.| |||||.||:.|.||:..:  :..
  Rat   120 SPAQGQAAMPGPPEEEQPVTK------GCGIAPLRGALEGS-RIIGGMQANAGAWPWQVSLQVQD 177

  Fly  1124 GPEKIFYCAGVLISDQWVLTASHCVGNYSVIDLEDWTIQLG---VTRRNSFTYSGQKVKVKAVIP 1185
            |...:..|.|.|:.|:|||||:||....|  |...|...:|   :||.:|.:.|   |:|..::.
  Rat   178 GNFLVHVCGGALVRDRWVLTAAHCTKEAS--DPLKWRAVIGTTDLTRSHSHSRS---VRVSDIVI 237

  Fly  1186 HPQYNMAIAHDNDIALFQL--ATRVAFH------EHLLPVCLPPPSVRNLHPGTLCTVIGWGK-- 1240
            .|.:.:. ...||||||.|  |.|....      :.|.|        ..||   .|.:..|.|
  Rat   238 QPDFILE-TFVNDIALFHLKKAVRTVLQNRGYGGQRLSP--------WKLH---TCVIPEWAKTI 290

  Fly  1241 REDKDPKSTYEYIVNEVQVPIITRNQCDEWLDNLTVSEGMV------CAGFDDGGKDACQGDSGG 1299
            |....| .....|:.|.:|..|:|..|     |...|.|.|      |||.::|..|.|:|||||
  Rat   291 RRSGAP-GNGTTILQEAKVHFISREIC-----NSDRSYGGVIPNTSFCAGHENGTFDTCRGDSGG 349

  Fly  1300 PLLCPYPGEKNRWFVGGIVSWGIMCAHPRLPGVYANVVQYVPWIQEQIA----KH 1350
            ||:| |..|..|:||.|:.|:|..|.....||||::...:..|:...::    ||
  Rat   350 PLMC-YLTEHKRYFVMGVTSYGHGCGRRHFPGVYSSPSFFQQWLTAYLSQGNTKH 403

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Corin	NP_610297.2	CRD_FZ	778..894	CDD:143549
		LDLa	911..942	CDD:238060
		LDLa	945..979	CDD:238060
		SR	980..>1034	CDD:214555	10/27 (37%)
		SRCR	992..1086	CDD:278931	19/88 (22%)
		Tryp_SPc	1103..1343	CDD:214473	88/260 (34%)
		Tryp_SPc	1104..1346	CDD:238113	88/262 (34%)
Tmprss12	XP_038936305.1	Tryp_SPc	155..391	CDD:214473	88/259 (34%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24253
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	3.010