DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG1598 and GET3

DIOPT Version :9

Sequence 1:	NP_610296.2	Gene:	CG1598 / 35690	FlyBaseID:	FBgn0033191	Length:	336	Species:	Drosophila melanogaster
Sequence 2:	NP_010183.1	Gene:	GET3 / 851458	SGDID:	S000002258	Length:	354	Species:	Saccharomyces cerevisiae

Alignment Length:	342	Identity:	163/342 - (47%)
Similarity:	227/342 - (66%)	Gaps:	25/342 - (7%)

- Green bases have known domain annotations that are detailed below.

  Fly     8 LEPSLQNLVEQDSLKWIFVGGKGGVGKTTCSSSLAVQ--LSKVRESVLIISTDPAHNISDAFDQK 70
            :||:|.:|:...:.|||||||||||||||.|.|:|:|  ||:..:..|:||||||||:||||.:|
Yeast     5 VEPNLHSLITSTTHKWIFVGGKGGVGKTTSSCSIAIQMALSQPNKQFLLISTDPAHNLSDAFGEK 69

  Fly    71 FTKVPTKVNGFDNLFAMEIDPNAGLNELPE--------EYFDGENEAL--RVSKGVMQEMINALP 125
            |.|...||.|.:||..|||||:|.|.::.:        ...||:.:.|  .:..|.:.::..::|
Yeast    70 FGKDARKVTGMNNLSCMEIDPSAALKDMNDMAVSRANNNGSDGQGDDLGSLLQGGALADLTGSIP 134

  Fly   126 GIDEAMSYAEVMKLVK------GMNFSVVVFDTAPTGHTLRLIAFPQVVEKGLGKLLRLKMKVAP 184
            |||||:|:.||||.:|      |..|..|:|||||||||||.:..|..:.|.|.|...:..|:.|
Yeast   135 GIDEALSFMEVMKHIKRQEQGEGETFDTVIFDTAPTGHTLRFLQLPNTLSKLLEKFGEITNKLGP 199

  Fly   185 LLSQFVSMLGMADVNADTLSQKLDDMLRVITQVNEQFKNPDQTTFVCVCIAEFFSLYETERLVQE 249
            :|:.|   :|..:|:   :|.||:::...:..:.:||.:||.||||||||:||.||||||||:||
Yeast   200 MLNSF---MGAGNVD---ISGKLNELKANVETIRQQFTDPDLTTFVCVCISEFLSLYETERLIQE 258

  Fly   250 LTKCGIDVHNIIVNQLLFLQNSHD-SCSMCASRFKIQEKYLDQIADLYEDFHVTKLPLLEKEVRG 313
            |....:||::||||||||.:|..: :|..|.:|:|:|:||||||.:|||||||.|:||...|:||
Yeast   259 LISYDMDVNSIIVNQLLFAENDQEHNCKRCQARWKMQKKYLDQIDELYEDFHVVKMPLCAGEIRG 323

  Fly   314 PESIRSFSENLMKPYNP 330
            ..::..||:.|.|.|||
Yeast   324 LNNLTKFSQFLNKEYNP 340

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG1598	NP_610296.2	ArsA_ATPase	21..326	CDD:280525	155/323 (48%)
CG1598	NP_610296.2	ArsA	37..330	CDD:223082	142/311 (46%)
GET3	NP_010183.1	GET3_arsA_TRC40	34..334	CDD:273027	139/305 (46%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C157345873
Domainoid	1	1.000	287	1.000	Domainoid score	I242
eggNOG	1	0.900	-	-		E1_COG0003
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H31513
Inparanoid	1	1.050	303	1.000	Inparanoid score	I495
Isobase	1	0.950	-	0	Normalized mean entropy	S527
OMA	1	1.010	-	-		QHG60619
OrthoFinder	1	1.000	-	-		FOG0004079
OrthoInspector	1	1.000	-	-		oto99357
orthoMCL	1	0.900	-	-		OOG6_100709
Panther	1	1.100	-	-	LDO	PTHR10803
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R486
SonicParanoid	1	1.000	-	-		X2829
TreeFam	1	0.960	-	-
	16	15.740