DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG1598 and GET3

DIOPT Version :9

Sequence 1:	NP_610296.2	Gene:	CG1598 / 35690	FlyBaseID:	FBgn0033191	Length:	336	Species:	Drosophila melanogaster
Sequence 2:	NP_001358417.1	Gene:	GET3 / 439	HGNCID:	752	Length:	348	Species:	Homo sapiens

Alignment Length:	329	Identity:	226/329 - (68%)
Similarity:	276/329 - (83%)	Gaps:	2/329 - (0%)

- Green bases have known domain annotations that are detailed below.

  Fly     2 ADNLEPLEPSLQNLVEQDSLKWIFVGGKGGVGKTTCSSSLAVQLSKVRESVLIISTDPAHNISDA 66
            |.::|||||:|.|::||.|||||||||||||||||||.||||||||.||||||||||||||||||
Human    18 APDVEPLEPTLSNIIEQRSLKWIFVGGKGGVGKTTCSCSLAVQLSKGRESVLIISTDPAHNISDA 82

  Fly    67 FDQKFTKVPTKVNGFDNLFAMEIDPNAGLNELPEEYFDGENEALRVSKGVMQEMINALPGIDEAM 131
            |||||:||||||.|:||||||||||:.|:.|||:|:|: |:..|.:.|.:|||.::|.|||||||
Human    83 FDQKFSKVPTKVKGYDNLFAMEIDPSLGVAELPDEFFE-EDNMLSMGKKMMQEAMSAFPGIDEAM 146

  Fly   132 SYAEVMKLVKGMNFSVVVFDTAPTGHTLRLIAFPQVVEKGLGKLLRLKMKVAPLLSQFVSMLGMA 196
            ||||||:|||||||||||||||||||||||:.||.:||:|||:|:::|.:::|.:||..:|||:.
Human   147 SYAEVMRLVKGMNFSVVVFDTAPTGHTLRLLNFPTIVERGLGRLMQIKNQISPFISQMCNMLGLG 211

  Fly   197 DVNADTLSQKLDDMLRVITQVNEQFKNPDQTTFVCVCIAEFFSLYETERLVQELTKCGIDVHNII 261
            |:|||.|:.||::.|.||..|:||||:|:||||:|||||||.||||||||:|||.||.||.||||
Human   212 DMNADQLASKLEETLPVIRSVSEQFKDPEQTTFICVCIAEFLSLYETERLIQELAKCKIDTHNII 276

  Fly   262 VNQLLFLQNSHDSCSMCASRFKIQEKYLDQIADLYEDFHVTKLPLLEKEVRGPESIRSFSENLMK 326
            ||||:| .:....|.||.:|.|||.|||||:.|||||||:.|||||..||||.:.:.:||..|::
Human   277 VNQLVF-PDPEKPCKMCEARHKIQAKYLDQMEDLYEDFHIVKLPLLPHEVRGADKVNTFSALLLE 340

  Fly   327 PYNP 330
            ||.|
Human   341 PYKP 344

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG1598	NP_610296.2	ArsA_ATPase	21..326	CDD:280525	212/304 (70%)
CG1598	NP_610296.2	ArsA	37..330	CDD:223082	198/292 (68%)
GET3	NP_001358417.1	ArsA_ATPase	37..340	CDD:396792	212/304 (70%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165158307
Domainoid	1	1.000	430	1.000	Domainoid score	I594
eggNOG	1	0.900	-	-		E1_COG0003
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H31513
Inparanoid	1	1.050	464	1.000	Inparanoid score	I1554
Isobase	1	0.950	-	0	Normalized mean entropy	S527
OMA	1	1.010	-	-		QHG60619
OrthoDB	1	1.010	-	-		D401779at33208
OrthoFinder	1	1.000	-	-		FOG0004079
OrthoInspector	1	1.000	-	-		oto89345
orthoMCL	1	0.900	-	-		OOG6_100709
Panther	1	1.100	-	-	LDO	PTHR10803
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R486
SonicParanoid	1	1.000	-	-		X2829
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	17	16.750