DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cyt-b5 and CYB5B

DIOPT Version :9

Sequence 1:	NP_610294.1	Gene:	Cyt-b5 / 35688	FlyBaseID:	FBgn0264294	Length:	134	Species:	Drosophila melanogaster
Sequence 2:	NP_085056.2	Gene:	CYB5B / 80777	HGNCID:	24374	Length:	150	Species:	Homo sapiens

Alignment Length:	131	Identity:	59/131 - (45%)
Similarity:	90/131 - (68%)	Gaps:	4/131 - (3%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 EETKTFTR-AEVAKHNTNKDTWLLIHNNIYDVTAFLNEHPGGEEVLIEQAGKDATENFEDVGHSN 67
            |.:.|:.| .||||.|:.|:.||:||..:||||.||||||||||||:||||.||:|:|||||||:
Human    21 ETSVTYYRLEEVAKRNSLKELWLVIHGRVYDVTRFLNEHPGGEEVLLEQAGVDASESFEDVGHSS 85

  Fly    68 DARDMMKKYKIGELVESERTSVAQKSEPTWSTEQQTEESSVKSWLVPLVLCLVATLFYKFFFGGA 132
            |||:|:|:|.||::..|:....:...:|   ::..|.:|....|::|::..::....|:::...:
Human    86 DAREMLKQYYIGDIHPSDLKPESGSKDP---SKNDTCKSCWAYWILPIIGAVLLGFLYRYYTSES 147

  Fly   133 K 133
            |
Human   148 K 148

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyt-b5	NP_610294.1	Cyt-b5	8..81	CDD:278597	50/73 (68%)
CYB5B	NP_085056.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..20
		Cyt-b5	28..100	CDD:365921	49/71 (69%)
		MIP	<123..148	CDD:350945	3/24 (13%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	109	1.000	Domainoid score	I6354
eggNOG	1	0.900	-	-		E1_COG5274
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	127	1.000	Inparanoid score	I4689
Isobase	1	0.950	-	0	Normalized mean entropy	S967
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1566561at2759
OrthoFinder	1	1.000	-	-		FOG0000784
OrthoInspector	1	1.000	-	-		otm42055
orthoMCL	1	0.900	-	-		OOG6_100589
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R279
SonicParanoid	1	1.000	-	-		X609
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	13	12.710