Protein Alignment Orc1 and CDC6

DIOPT Version :9

• Sequence 1: NP_477303.1
• Gene: Orc1 / 35686
• FlyBaseID: FBgn0286788
• Length: 924
• Species: Drosophila melanogaster
• Sequence 2: XP_011523843.1
• Gene: CDC6 / 990
• HGNCID: 1744
• Length: 600
• Species: Homo sapiens
• Alignment Length: 611
• Identity: 148/611 - (24%)
• Similarity: 250/611 - (40%)
• Gaps: 142/611 - (23%)

  Fly   406 SKEPLESAAATEQTPSTRRKSILKSATSRLAEGTPRRSIHLSNIVEQRVFEDDEIISTPKRGRSK 470
            |...||.......|.|.|.|::..|...||.                    ||.:.:||......
Human    30 SDAKLEPTNVQTVTCSPRVKALPLSPRKRLG--------------------DDNLCNTPHLPPCS 74

  Fly   471 KTVQDNDEDYSPKKSVQKTPTRTRRSSTTTKTATTPSKGITTATATPMTPSQKMKKI-------- 527
            ...|...|:..|.....|.......:..|.|   :|||             :::.|:
Human    75 PPKQGKKENGPPHSHTLKGRRLVFDNQLTIK---SPSK-------------RELAKVHQNKILSS 123

  Fly   528 --RAGELSPSMQQRTDLPAKDSS-----KSE---LQLAREQLHVSVVPKSLPCREREFENIYAFL 582
              ::.|::.:.:||..| .|:|:     |.|   .|.|:..|: :.||..||.||||.:.|..||
Human   124 VRKSQEITTNSEQRCPL-KKESACVRLFKQEGTCYQQAKLVLN-TAVPDRLPAREREMDVIRNFL 186

  Fly   583 EGKIQDQCGGCMYVSGVPGTGKTATVTGVIRTLQRMAKQNELPAFEYLEINGMRLTEPRQAYVQI 647
            ...|..:..|.:|:||.|||||||.::.:::.|::     ||..|:.:.:|.|.|...:..:..|
Human   187 REHICGKKAGSLYLSGAPGTGKTACLSRILQDLKK-----ELKGFKTIMLNCMSLRTAQAVFPAI 246

  Fly   648 YKQLTGKTVSWEQAHAL---LEKRFTTPAPRRVTTVLLVDELDILCNRRQDVVYNLLDWPTKSAA 709
            .:::..:.||......:   |||..|  |.:....||::||:|.|.::.|||:|.|.:||..|.:
Human   247 AQEICQEEVSRPAGKDMMRKLEKHMT--AEKGPMIVLVLDEMDQLDSKGQDVLYTLFEWPWLSNS 309

  Fly   710 KLVVVTIANTMDLPERLL-----MGKVTSRLGLTRLTFQPYSHKQLQEIVTARL---GGSETFKG 766
            .||::.||||:||.:|:|     ..|...:|    |.|.||:..|:..|:..||   ...:....
Human   310 HLVLIGIANTLDLTDRILPRLQAREKCKPQL----LNFPPYTRNQIVTILQDRLNQVSRDQVLDN 370

  Fly   767 EAVQLVARKVAAVSGDARRALDICR---------------------------------------- 791
            .|||..||||:|||||.|:|||:||
Human   371 AAVQFCARKVSAVSGDVRKALDVCRKEDLFLSGELWISTVLMSETLSVHYLQREKQMRCCWHSLW 435

  Fly   792 RATEIADT--------------------AAVKCVTMLHVQQALAEM----IASAKVQAIRNCSRM 832
            ||.||.::                    ...|.|.::|:.|.::|:    :..::..|..:....
Human   436 RAIEIVESDVKSQTILKPLSECKSPSEPLIPKRVGLIHISQVISEVDGNRMTLSQEGAQDSFPLQ 500

  Fly   833 EQIFLQAIAAEVTRTGVEETTFMGVYQQVETIAAFMGVTFPPPGRALRLCSKLGAERLIISEHSR 897
            ::|.:.::...:.:..::|.|...:|:....:.....|........|.|...|.|..::..:.::
Human   501 QKILVCSLMLLIRQLKIKEVTLGKLYEAYSKVCRKQQVAAVDQSECLSLSGLLEARGILGLKRNK 565

  Fly   898 NDLFQKILLNVSADDIHYALRVEEMV 923
            .....|:...:...:|.:||:.:.::
Human   566 ETRLTKVFFKIEEKEIEHALKDKALI 591

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Orc1	NP_477303.1	BAH_Orc1p_animal	44..185	CDD:240070
		AAA	591..741	CDD:214640	52/157 (33%)
		AAA	594..739	CDD:278434	51/152 (34%)
		Cdc6_C	837..917	CDD:215013	10/79 (13%)
CDC6	XP_011523843.1	CDC6	168..587	CDD:224391	113/429 (26%)
		AAA_16	171..314	CDD:289934	52/149 (35%)
		Cdc6_C	505..585	CDD:215013	10/79 (13%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1474
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D427050at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100406
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R177
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	5	4.750