DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Orc1 and SIR3

DIOPT Version :9

Sequence 1:	NP_477303.1	Gene:	Orc1 / 35686	FlyBaseID:	FBgn0286788	Length:	924	Species:	Drosophila melanogaster
Sequence 2:	NP_013547.3	Gene:	SIR3 / 851163	SGDID:	S000004434	Length:	978	Species:	Saccharomyces cerevisiae

Alignment Length:	747	Identity:	141/747 - (18%)
Similarity:	258/747 - (34%)	Gaps:	176/747 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly   246 SSVEFIDVNSFI----CE---NKVSPIKI-------------------------VGGRSVVRLSE 278
            ||::.|:...|:    ||   .|..||.|                         |.|:...|...
Yeast   161 SSIDKIEDRDFLVRYACEPTAEKFVPIDIFQIIRRVKEMEPKQSDEYLKRVSVPVSGQKTNRQVM 225

  Fly   279 KKNAPEINANYLPASPLTEKNAKVETPKSRASAARRNLNLSLDRGADTTADS-----DCLNYSIV 338
            .|...|.::..|...| :.|..|:|   ..|.....|.|:...||..||..|     :.::.:|.
Yeast   226 HKMGVERSSKRLAKKP-SMKKIKIE---PSADDDVNNGNIPSQRGTSTTHGSISPQEESVSPNIS 286

  Fly   339 QQTPDPKT-PSNDMKIKLRLSERRRSVRLASMDVDPL--SLEEAVQEPN---------------- 384
            ..:|...| |::..||   |.:|..|..|...:..|:  |.:|:..|||
Yeast   287 SASPSALTSPTDSSKI---LQKRSISKELIVSEEIPINSSEQESDYEPNNETSVLSSKPGSKPEK 348

  Fly   385 -----AQGRKRLGVANGDIYHTPTKKSKEPLESAAATEQTPSTRRKSILKSATSRLAEGTPRRSI 444
                 ..||:....||          :.|..:.....|:|.....    :|:...:.....||..
Yeast   349 TSTELVDGRENFVYAN----------NPEVSDDGGLEEETDEVSS----ESSDEAIIPVNKRRGA 399

  Fly   445 HLSNIVEQRVFEDDEIISTPKRGRSKKTVQDNDEDYSPKKSVQKTPTRTRRSSTTTKTATTPSKG 509
            |.|.:..:  .....|..|.:..::..|..||:.:.:.|..:.:..|:....:..    .||.||
Yeast   400 HGSELSSK--IRKIHIQETQEFSKNYTTETDNEMNGNGKPGIPRGNTKIHSMNEN----PTPEKG 458

  Fly   510 ----ITTATATPM-----------------TPSQKMKKIRAGELSPSMQQRTDLPAKDSSKSELQ 553
                |..||.:.:                 |.|.::.|:...:.|..:....|...|..|.|..:
Yeast   459 NAKMIDFATLSKLKKKYQIILDRFAPDNQVTDSSQLNKLTDEQSSLDVAGLEDKFRKACSSSGRE 523

  Fly   554 LAREQLHVSV-----VPKSLPCRE------REFENIYAFLEGKIQDQCGGCMYVSGVPGTGKTAT 607
            ......:..:     :.:||..||      .:|..|:..:...:........|::....:.|...
Yeast   524 TILSNFNADINLEESIRESLQKRELLKSQVEDFTRIFLPIYDSLMSSQNKLFYITNADDSTKFQL 588

  Fly   608 VTGVIRTLQRMAKQNELPAFEYLEINGMRLTEPRQAYVQIYKQLTGKTVSWEQAHALLEKRFT-T 671
            |..|:..|...:.:.|||.|:|:.|:.:.|......|.:|:..::.:.:..:.:...|....| .
Yeast   589 VNDVMDELITSSARKELPIFDYIHIDALELAGMDALYEKIWFAISKENLCGDISLEALNFYITNV 653

  Fly   672 PAPRRVTTVLLVDELDILCNRRQDVVYNLLDWPTKSAAKLVVVTI-ANTMDLPERL-LMGKVTSR 734
            |..::..|::|:...:.|.:.:  ::.....|.:...:||.::.: .:.:.:.|:: :|..:.:.
Yeast   654 PKAKKRKTLILIQNPENLLSEK--ILQYFEKWISSKNSKLSIICVGGHNVTIREQINIMPSLKAH 716

  Fly   735 LGLTRLTFQPYSHKQLQEIVTARLGG------------------------------------SET 763
              .|.:........:||:::..||..                                    :..
Yeast   717 --FTEIKLNKVDKNELQQMIITRLKSLLKPFHVKVNDKKEMTIYNNIREGQNQKIPDNVIVINHK 779

  Fly   764 FKGEAVQLVARKVAAVSGDARRALDICRRATEIADTAAVK---------CVTMLHVQQALAEMIA 819
            ...:..||:|:.||.|||...:|..||..|.||:....|:         .|:...|.:..:|.|.
Yeast   780 INNKITQLIAKNVANVSGSTEKAFKICEAAVEISKKDFVRKGGLQKGKLVVSQEMVPRYFSEAIN 844

  Fly   820 SAKVQAIR----NCSRMEQIFLQAIAAEVTRT 847
            ..|.:.|.    ..|.:.:.||..:|.|...|
Yeast   845 GFKDETISKKIIGMSLLMRTFLYTLAQETEGT 876

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Orc1	NP_477303.1	BAH_Orc1p_animal	44..185	CDD:240070
		AAA	591..741	CDD:214640	26/152 (17%)
		AAA	594..739	CDD:278434	25/147 (17%)
		Cdc6_C	837..917	CDD:215013	4/11 (36%)
SIR3	NP_013547.3	BAH_Orc1p_Yeast	5..189	CDD:240071	9/27 (33%)
SIR3	NP_013547.3	CDC6	528..962	CDD:224391	63/353 (18%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C157343784
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1474
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	49	1.000	Inparanoid score	I1850
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0003590
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X2463
TreeFam	0	0.000	Not matched by this tool.
	6	5.790