DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Orc1 and ORC1A

DIOPT Version :9

Sequence 1:	NP_477303.1	Gene:	Orc1 / 35686	FlyBaseID:	FBgn0286788	Length:	924	Species:	Drosophila melanogaster
Sequence 2:	NP_567440.1	Gene:	ORC1A / 827121	AraportID:	AT4G14700	Length:	809	Species:	Arabidopsis thaliana

Alignment Length:	872	Identity:	246/872 - (28%)
Similarity:	387/872 - (44%)	Gaps:	187/872 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly   155 LKRHANKLKS-TACPMFVSRYRFVKVKRSYRLIPLEIHLEQPEDNARPTRSSRKSLTAHRESKRS 218
            |...|...|| |..|        .|:.|...|.|....|..|:        :.::||..|.|.|.
plant     5 LSSKAKTFKSPTKTP--------TKMYRKSYLSPSSTSLTPPQ--------TPETLTPLRRSSRH 53

  Fly   219 ISARHDDTAGNKGSSVEKRRRASMAASSSVEFIDVNSFICENKVSPIKIVGGRSVVRLSEKKNAP 283
            :|.:.     |.|:.     ...:....|||  ::|......|.:...:|..:|    .:||..|
plant    54 VSRKI-----NLGND-----PIDLPGKESVE--EINLIRKPRKRTNDIVVAEKS----KKKKIDP 102

  Fly   284 EINANYLPASPLTEKNAKVETPK----SRASAARRNLNLSLD----RGADTTAD----------- 329
            |:  ::.|.||:..:..|.:..|    ::.........:..|    |..|...|
plant   103 EV--SFSPVSPIRSETKKTKKKKRVYYNKVEFDETEFEIGDDVYVKRTEDANPDEEEEEDPEIED 165

  Fly   330 ----------------SDCL--------------------------------NYSIVQQTPDPKT 346
                            .|||                                ...:|.:.|:.|.
plant   166 CQICFKSHTNTIMIECDDCLGGFHLNCLKPPLKEVPEGDWICQFCEVKKSGQTLVVVPKPPEGKK 230

  Fly   347 PSNDMKIKLRLSERRRSVRLASM--DVDP-----LSLEEAVQEPNAQGRKRLGVANGDIYHTPTK 404
            .:..||.|| ||....:.|:..:  :||.     .:....:.|....||:|..:.. ::|
plant   231 LARTMKEKL-LSSDLWAARIEKLWKEVDDGVYWIRARWYMIPEETVLGRQRHNLKR-ELY----- 288

  Fly   405 KSKEPLESAAATEQTPSTRRKSILKSATSRLAEGTPRRS--------------IHLSNIVEQRVF 455
                      .|........:.:|:....:..:...:.|              :|..:.  :||.
plant   289 ----------LTNDFADIEMECVLRHCFVKCPKEFSKASNDGDDVFLCEYEYDVHWGSF--KRVA 341

  Fly   456 E---DDEIISTPKRGRSKKTVQDNDE--DYSPKKSVQKTPTRTRRSSTTTKTATTPSKGITTATA 515
            |   .||.......||.::.:..:||  ::..::||:.. ::::|....::      ||
plant   342 ELADGDEDSDQEWNGRKEEEIDYSDEEIEFDDEESVRGV-SKSKRGGANSR------KG------ 393

  Fly   516 TPMTPSQKMKKIRAGELSPSMQQRTDLPAKDSSKSELQLAREQLHVSVVPKSLPCREREFENIYA 580
                        |...|.....:|.....:...:|||:.|:..|.::..|||||||.:|.|.|.|
plant   394 ------------RFFGLEKVGMKRIPEHVRCHKQSELEKAKATLLLATRPKSLPCRSKEMEEITA 446

  Fly   581 FLEGKI-QDQC-GGCMYVSGVPGTGKTATVTGVIRTLQRMAKQNELPAFEYLEINGMRLTEPRQA 643
            |::|.| .||| |.|||:.||||||||.:|..|::.|:...:...:..:.::||||::|..|...
plant   447 FIKGSISDDQCLGRCMYIHGVPGTGKTISVLSVMKNLKAEVEAGSVSPYCFVEINGLKLASPENI 511

  Fly   644 YVQIYKQLTGKTVSWEQAHALLEKRFT----TPAPRRVTTVLLVDELDILCNRRQDVVYNLLDWP 704
            |..||:.|:|..|.|::|...|.:||.    .........:||:||||:|..|.|.|:||:||||
plant   512 YSVIYEGLSGHRVGWKKALQSLNERFAEGKKIGKENEKPCILLIDELDVLVTRNQSVLYNILDWP 576

  Fly   705 TKSAAKLVVVTIANTMDLPERLLMGKVTSRLGLTRLTFQPYSHKQLQEIVTARLGGSETFKGEAV 769
            ||..:||||:.|||||||||:|| .:::||:|:.||.|.||:|:|||||::.||.|...|:..|:
plant   577 TKPNSKLVVLGIANTMDLPEKLL-PRISSRMGIQRLCFGPYNHRQLQEIISTRLEGINAFEKTAI 640

  Fly   770 QLVARKVAAVSGDARRALDICRRATEIAD--------TAAVKCVTMLHVQQALAEMIASAKVQAI 826
            :..:|||||:||||||||:|||||.|:||        :|..:.|.|..|:.|:.||..:..:|.:
plant   641 EFASRKVAAISGDARRALEICRRAAEVADYRLKKSNISAKSQLVIMADVEVAIQEMFQAPHIQVM 705

  Fly   827 RNCSRMEQIFLQAIAAEVTRTGVEETTFMGVYQQVETIAAFMGVTFPPPGRALRLCSKLGAERLI 891
            ::.|::.:|||.|:..|:.:||:.||:|..|...|.:|....|..||.....|::...||..|::
plant   706 KSVSKLSRIFLTAMVHELYKTGMAETSFDRVATTVSSICLTNGEAFPGWDILLKIGCDLGECRIV 770

  Fly   892 ISEHSRNDLFQKILLNVSADDIHYALR 918
            :.|.......||:.||..:||:.:||:
plant   771 LCEPGEKHRLQKLQLNFPSDDVAFALK 797

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Orc1	NP_477303.1	BAH_Orc1p_animal	44..185	CDD:240070	8/30 (27%)
		AAA	591..741	CDD:214640	69/153 (45%)
		AAA	594..739	CDD:278434	66/148 (45%)
		Cdc6_C	837..917	CDD:215013	25/79 (32%)
ORC1A	NP_567440.1	BAH_plant_2	187..341	CDD:240069	22/172 (13%)
		AAA	459..605	CDD:214640	65/146 (45%)
		AAA	462..610	CDD:278434	66/148 (45%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	1	1.000	131	1.000	Domainoid score	I1682
eggNOG	1	0.900	-	-		E1_COG1474
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D935804at2759
OrthoFinder	1	1.000	-	-		FOG0003590
OrthoInspector	1	1.000	-	-		otm2933
orthoMCL	1	0.900	-	-		OOG6_100406
Panther	1	1.100	-	-	O	PTHR10763
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X2463
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	12	11.780