DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Orc1 and orc1

DIOPT Version :9

Sequence 1:	NP_477303.1	Gene:	Orc1 / 35686	FlyBaseID:	FBgn0286788	Length:	924	Species:	Drosophila melanogaster
Sequence 2:	NP_001039194.1	Gene:	orc1 / 734048	XenbaseID:	XB-GENE-997997	Length:	888	Species:	Xenopus tropicalis

Alignment Length:	1005	Identity:	342/1005 - (34%)
Similarity:	508/1005 - (50%)	Gaps:	232/1005 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly    16 WIGSQDELPPVKNLEHKNVYFYQKCI----YGPLTLSVGDFILVSNADAAEPDTVSGCDVARILH 76
            |.|.    |.:|:.:..|:::....|    .|.:|::.|||:|:...:...|      .||::..
Frog    16 WKGR----PSIKDRKLLNLHYGGLDIKSEGTGYITVTPGDFVLIEGENEERP------FVAKLQE 70

  Fly    77 MYELRELTDREPCR-AIVQWYSWPKAIPHNK---------------YDDDEVAIDFSLEVI---- 121
            :|:  :..::...: |||||:...:.:|:.|               ||......|...|.|
Frog    71 LYD--DGNEKHTSKHAIVQWFLRYEEVPYRKRALLGREPHQQEIFLYDVPSCENDIDAETIIGRV 133

  Fly   122 -------EEHRPYDNDVALGAIYRKCI------------VLEGTSKTSAEEILKRHANKLKSTAC 167
                   |:..|...|.  |:::.|..            |.......:|...|:.| |.|..
Frog   134 EVTQLKPEDSFPVQKDA--GSLFVKLSWNGKAFKPLTSNVCHNDGVIAANHDLEDH-NSLPK--- 192

  Fly   168 PMFVSRYRFVKVKRSYRLIPLEIHLEQPEDNARPTRSSRKSLTAHRESKRSISARHDDTAGNKGS 232
            |:|               .|||..:   .::.:.|||:.:.    ::::..:.:||   :.:|.|
Frog   193 PLF---------------YPLEGDI---AESKQITRSASRG----QKNEAEVESRH---SASKSS 232

  Fly   233 SVEKR--RRASMAASSSVEFIDVNSFICENKV---SPIKIVGGRSVVRLSEKKN----------- 281
            ..::|  :|.|..::..          ...|:   ||.|    ..|..|.:|.|
Frog   233 HCKERGVQRVSTTSTPG----------ARKKLQLSSPTK----SGVPGLEQKDNTLDEEFKILES 283

  Fly   282 -APEINANY--LPASPLTEKNAKVETPKS----------RASAARRNLNL------------SLD 321
             ||:....:  :|.||  .|....:||:|          .:...|.:|.|            ||.
Frog   284 IAPKRKVAFSGIPDSP--PKKVNGDTPRSTGILPLKGNTNSQTTRHSLRLTPMRRPLEQLYGSLP 346

  Fly   322 RGADTTADSDCLNYSIVQQTPDPKTPSNDMKIKLRLSERRRSVRLASMDVDPLSLEEAVQEPNAQ 386
            :  |.:....|:      :....|...|:..:|.:               .|..||...::..::
Frog   347 K--DQSLGKICI------EANGNKAADNERPVKSK---------------TPQKLEPTPKKSTSR 388

  Fly   387 GRKRLGVANGDIYHTPTKKSKEPLESAAATEQTPSTRRKSILKSATSRLAEGTPRRSIHLSNIVE 451
                           |:|:|:|..|.   ..|||.:||.|      :|:.....|..:......:
Frog   389 ---------------PSKRSEEDFEE---EPQTPRSRRTS------ARMTANKVRAQLKALMDSD 429

  Fly   452 QRVFEDDEIISTPKRGRSKKTVQDNDEDYSP-KKSVQK------TPTRTRRSSTTTKTATTPSKG 509
            :.|.||.:.:...:......:.::|:::..| |::|:|      |||.:|::|:.|...|..||
Frog   430 EDVDEDKDFVPIKETCTPSDSEEENEQEQVPLKRNVKKGCATPRTPTSSRKASSRTPNKTPNSK- 493

  Fly   510 ITTATATPMTP--SQKMKKIRAGELSPSMQQRTDLPAKDSSKSELQLAREQLHVSVVPKSLPCRE 572
             |..:|||..|  :|.:||       ||              :.|:.||.:||||.||:||||||
Frog   494 -TPHSATPRIPERNQPVKK-------PS--------------NMLEEARIRLHVSAVPESLPCRE 536

  Fly   573 REFENIYAFLEGKIQDQCGGCMYVSGVPGTGKTATVTGVIRTLQRMAKQNELPAFEYLEINGMRL 637
            :|::::|.|:|.|:.|..|||||:||||||||||||..|||:||..|::.|||:|:|:|||||:|
Frog   537 QEYQDVYNFVESKLLDGTGGCMYISGVPGTGKTATVHEVIRSLQESAEEEELPSFQYIEINGMKL 601

  Fly   638 TEPRQAYVQIYKQLTGKTVSWEQAHALLEKRFTTPAPRRVTTVLLVDELDILCNRRQDVVYNLLD 702
            |:|.||||||.|.|||:..:.:.|.|||||||:|||.::.||||||||||:|..|:|:|:|:|.|
Frog   602 TDPHQAYVQILKLLTGQKATADHAAALLEKRFSTPASKKETTVLLVDELDLLWTRKQNVMYSLFD 666

  Fly   703 WPTKSAAKLVVVTIANTMDLPERLLMGKVTSRLGLTRLTFQPYSHKQLQEIVTARLGGSETFKGE 767
            |||:..|||:|:.||||||||||::|.:|.|||||||::||||:|||||:|:|:||...:.|..:
Frog   667 WPTRKHAKLIVLAIANTMDLPERIMMNRVASRLGLTRMSFQPYTHKQLQQIITSRLNHIKAFGDD 731

  Fly   768 AVQLVARKVAAVSGDARRALDICRRATEI-------ADTAAVKCVTMLHVQQALAEMIASAKVQA 825
            |:|||||||||:||||||.||||||||||       .|::.||   |.||.:||.||.:|..|.|
Frog   732 AIQLVARKVAALSGDARRCLDICRRATEICEFSCKMGDSSLVK---MSHVMEALEEMFSSPYVTA 793

  Fly   826 IRNCSRMEQIFLQAIAAEVTRTGVEETTFMGVYQQVETIAAFMGVTFPPPGRALRLCSKLGAERL 890
            |||.|.|||.||:|:.||..|:|:||.||..:|:|...:....|:..|.....:.:|.:|||.||
Frog   794 IRNSSLMEQTFLRAVIAEFRRSGLEEATFQQIYRQHVVLCRIEGLQPPLMSETMAVCHRLGASRL 858

  Fly   891 IISEHSRNDLFQKILLNVSADDIHYALRVE 920
            ::.|.|||||..::.:|||.|||.|||:.|
Frog   859 LLVESSRNDLHLRVRINVSQDDIMYALKEE 888

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Orc1	NP_477303.1	BAH_Orc1p_animal	44..185	CDD:240070	34/179 (19%)
		AAA	591..741	CDD:214640	100/149 (67%)
		AAA	594..739	CDD:278434	95/144 (66%)
		Cdc6_C	837..917	CDD:215013	33/79 (42%)
orc1	NP_001039194.1	BAH_Orc1p_animal	45..169	CDD:240070	26/133 (20%)
		AAA_16	532..>582	CDD:289934	33/49 (67%)
		AAA	554..704	CDD:214640	99/149 (66%)
		AAA	558..703	CDD:278434	95/144 (66%)
		Cdc6_C	798..881	CDD:176573	35/82 (43%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	195	1.000	Domainoid score	I3082
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	455	1.000	Inparanoid score	I1548
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D427050at33208
OrthoFinder	1	1.000	-	-		FOG0003590
OrthoInspector	1	1.000	-	-		oto104190
Panther	1	1.100	-	-	LDO	PTHR10763
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R177
SonicParanoid	1	1.000	-	-		X2463
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	11	11.100