DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Orc1 and orc1

DIOPT Version :9

Sequence 1:	NP_477303.1	Gene:	Orc1 / 35686	FlyBaseID:	FBgn0286788	Length:	924	Species:	Drosophila melanogaster
Sequence 2:	XP_005166338.1	Gene:	orc1 / 554509	ZFINID:	ZDB-GENE-030131-6960	Length:	912	Species:	Danio rerio

Alignment Length:	1044	Identity:	347/1044 - (33%)
Similarity:	500/1044 - (47%)	Gaps:	273/1044 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 KENARSVGQQVKWIGSQDELPPVKNLEHKNVYFYQKCIYGPL-----------TLSVGDFILVSN 57
            |.|.|.||:..|                     .::..||.:           |:|:|.:||:..
Zfish    15 KWNGRPVGEDRK---------------------LRRQYYGSMSISVDGRTEDVTVSLGQYILIEG 58

  Fly    58 ADAAEPDTVSGCDVARILHMYELRELTDR--EPCRAIVQW----YSWPK-------AIPH----- 104
            .:...|      .||::|.:|     ||.  :...|:|||    |..|:       ..||
Zfish    59 ENDDNP------FVAQLLKLY-----TDESGKMKTAVVQWFVRMYEVPQYKRKLLGRDPHPQEVF 112

  Fly   105 --------NKYDDDEVAIDFSLEVIEEHRPYDNDVALGAIYRKCIVLEGTSKTSAEEILKRHANK 161
                    |:.|.:.:.....:..|....|:.               ||.||   :.:..:|:..
Zfish   113 FYQDSSCDNEVDGESILAPVQIMYIAPEHPFP---------------EGKSK---DMLFVKHSWD 159

  Fly   162 LKSTACPMFVSRYRFVKVKRSYRLIPLEIHLEQPEDNARPTRSSR----KSLTAHRES--KRSIS 220
            .|                  |::.:..|: :|.|.....|..|||    :.|.....|  ||:|:
Zfish   160 TK------------------SFQAVDPEL-IEPPPSPKSPPPSSRGPQARPLPTPDPSIMKRAIT 205

  Fly   221 ARHDDTAGNKGSSVEKRRRASMAASSSVEFIDVNSFICENKVSPIKIVGGRSVVRLSEKKNAPEI 285
            .     |..:||       .|....||.|...::|   .:|:|..|.:   |..|.|...:.|.:
Zfish   206 G-----AITRGS-------MSTGKMSSTEAESLHS---ASKLSAAKAL---SAKRRSRASSGPHV 252

  Fly   286 NANYLPASPLTEKNAKVETPKSRASAARRNLNLSLDRGADTTADSDCLNYSIVQQTPDPKTPSND 350
            .......||  .||      .||.......|:..:|  .|.|..|. :|.|          ||..
Zfish   253 RKKLELCSP--SKN------MSRDDVLGEILDKHID--TDKTLMSK-MNTS----------PSGR 296

  Fly   351 MKIKLRL-----SERRRSVRLASM--------------------------DVDPLSLEEAVQEP- 383
            :.|.:||     :|.::.:.|:|.                          |.||.||....:.|
Zfish   297 ISISIRLTPLKCNEEQQILPLSSHSPDKPTLTAYGSDSATSVFLGVPALGDDDPESLNNTGRTPR 361

  Fly   384 NAQGRKRLGVANGDIYHTPTKKS-----KEPL----------ESAAATEQTPSTRRKSILKSATS 433
            ..:...|.....|....||:::.     |||.          :|.|.|..||.::|||      :
Zfish   362 KREATPRRASVRGLKARTPSRRKDSASLKEPALTALAEEEHEDSPAQTAATPRSKRKS------A 420

  Fly   434 RLAEGTPRRSIHL----------------------SNI---------VEQRVFEDDEIISTPKRG 467
            :|.....|:.::|                      |.|         :|.:|..:||::...:||
Zfish   421 QLVSSRIRKQLNLIANKFDLQSDGEDGDEDDCFVPSKIDLQSSSDEELEAKVDSEDELVVKKRRG 485

  Fly   468 RSKKTVQDNDEDYSPKKSVQKTPTRTRRSSTTTKT-ATTPSKGITTATATPMTPSQKMKKIRAGE 531
                               .:||..|.:|..:.:| ..||||  ..|.:||.||.         .
Zfish   486 -------------------SRTPRATDKSCVSARTPCKTPSK--KAAPSTPRTPR---------H 520

  Fly   532 LSPSMQQRTDLPAKDSSKSELQLAREQLHVSVVPKSLPCREREFENIYAFLEGKIQDQCGGCMYV 596
            .:||:..|| .||:... :.|:.||.:||||.||:||||||:||::||.|:|.|:.|..|||||:
Zfish   521 ATPSIPSRT-APARKPG-NVLEEARARLHVSAVPESLPCREQEFQDIYNFVESKVIDGTGGCMYI 583

  Fly   597 SGVPGTGKTATVTGVIRTLQRMAKQNELPAFEYLEINGMRLTEPRQAYVQIYKQLTGKTVSWEQA 661
            ||||||||||||..|||:||:.|:|:|:|.|.::|||||::|:|.||||||.::||.:..:.:.|
Zfish   584 SGVPGTGKTATVHEVIRSLQQSAEQDEIPHFNFIEINGMKMTDPHQAYVQILQKLTDQKATSDHA 648

  Fly   662 HALLEKRFTTPAPRRVTTVLLVDELDILCNRRQDVVYNLLDWPTKSAAKLVVVTIANTMDLPERL 726
            .|||||||:.|||::.||||||||||:|..|:|:|:|||.||||:..|:|||:|||||||||||:
Zfish   649 AALLEKRFSAPAPKKETTVLLVDELDLLWTRKQNVMYNLFDWPTRRNARLVVLTIANTMDLPERI 713

  Fly   727 LMGKVTSRLGLTRLTFQPYSHKQLQEIVTARLGGSETFKGEAVQLVARKVAAVSGDARRALDICR 791
            ::.:|.|||||||::||||:.||||:|:|:||...:.|:.:|:|||:|||||:||||||.|||||
Zfish   714 MINRVASRLGLTRMSFQPYTFKQLQQIITSRLNRVKAFEEDALQLVSRKVAALSGDARRCLDICR 778

  Fly   792 RATEIADTAAVK-----CVTMLHVQQALAEMIASAKVQAIRNCSRMEQIFLQAIAAEVTRTGVEE 851
            |||||.:.:..:     .|.|.||.:||.||.:|:.:.|||:.|..||:.|:|:.||..|.|:||
Zfish   779 RATEICEHSGNQQKGSGLVGMSHVMEALDEMFSSSYIAAIRSASVQEQLLLRAVIAEFRRLGLEE 843

  Fly   852 TTFMGVYQQVETIAAFMGVTFPPPGRALRLCSKLGAERLIISEHSRNDLFQKILLNVSADDIHYA 916
            .||..|:.|.:.:....|:........|.:|.:||:.||::.|.||.|||.:|.||||.||:.||
Zfish   844 ATFQQVFVQHQALCRVEGLQPVSVSEGLLVCQRLGSCRLLLLEGSRLDLFLRIRLNVSQDDVLYA 908

  Fly   917 LRVE 920
            |:.:
Zfish   909 LKAD 912

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Orc1	NP_477303.1	BAH_Orc1p_animal	44..185	CDD:240070	31/177 (18%)
		AAA	591..741	CDD:214640	97/149 (65%)
		AAA	594..739	CDD:278434	92/144 (64%)
		Cdc6_C	837..917	CDD:215013	33/79 (42%)
orc1	XP_005166338.1	BAH_Orc1p_animal	45..168	CDD:240070	31/169 (18%)
		AAA	577..727	CDD:214640	96/149 (64%)
		AAA	581..726	CDD:278434	92/144 (64%)
		Cdc6_C	822..905	CDD:176573	34/82 (41%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170580581
Domainoid	1	1.000	192	1.000	Domainoid score	I3170
eggNOG	1	0.900	-	-		E1_COG1474
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	428	1.000	Inparanoid score	I1714
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D427050at33208
OrthoFinder	1	1.000	-	-		FOG0003590
OrthoInspector	1	1.000	-	-		oto41764
orthoMCL	1	0.900	-	-		OOG6_100406
Panther	1	1.100	-	-	LDO	PTHR10763
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R177
SonicParanoid	1	1.000	-	-		X2463
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	15	14.790