DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Orc1 and ORC1

DIOPT Version :9

Sequence 1:	NP_477303.1	Gene:	Orc1 / 35686	FlyBaseID:	FBgn0286788	Length:	924	Species:	Drosophila melanogaster
Sequence 2:	NP_001177747.1	Gene:	ORC1 / 4998	HGNCID:	8487	Length:	861	Species:	Homo sapiens

Alignment Length:	976	Identity:	323/976 - (33%)
Similarity:	478/976 - (48%)	Gaps:	201/976 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly    16 WIGSQDELPPVKNLEHKNVYFYQKCI-----YGPLTLSVGDFILVSNADAAEPDTVSGCDVARIL 75
            |:|.    |.:....|...| .:.|:     ...:.:.:|.|:|:...|...|      .||::|
Human    16 WVGR----PLLDRKLHYQTY-REMCVKTEGCSTEIHIQIGQFVLIEGDDDENP------YVAKLL 69

  Fly    76 HMYE-------------------------LRELTDREPCRAIVQWYSWPKAIPHNKYDDDEVAID 115
            .::|                         .|.|..|:|....:.||.:|             |.|
Human    70 ELFEDDSDPPPKKRARVQWFVRFCEVPACKRHLLGRKPGAQEIFWYDYP-------------ACD 121

  Fly   116 FSLEVIEEHRPYDNDVALGAIYRKCIVLEGTSKTSAEEILKRHANKLKSTACPMFVSRYRFVKV- 179
            .::..         :..:|.:  :.|.|      :.::::..:....|:.          |||:
Human   122 SNINA---------ETIIGLV--RVIPL------APKDVVPTNLKNEKTL----------FVKLS 159

  Fly   180 --KRSYRLIPLEI--HLEQPEDNA----RPTRSSRKS------LTAHRESKRSISARHDDTAGNK 230
              ::.:|.:..|:  .|.:|:::|    :|.|:..||      ..|...:|| |.:||..:...:
Human   160 WNEKKFRPLSSELFAELNKPQESAAKCQKPVRAKSKSAESPSWTPAEHVAKR-IESRHSASKSRQ 223

  Fly   231 GS----SVEKRRRASMAASSSVEFIDVNSFICENKVSPIKIVGGRSVVRLSE-----KKNAPEIN 286
            ..    :...|:|..:....:.:.....|  |.:..||.:|   :..|..||     |::.|:
Human   224 TPTHPLTPRARKRLELGNLGNPQMSQQTS--CASLDSPGRI---KRKVAFSEITSPSKRSQPD-- 281

  Fly   287 ANYLPASPLTEKNAKVET--PKSRASAARRNLNLSLDRGADTTADSDCLNYSIVQQTPDPKTPSN 349
                          |::|  |..:|....|...||                    .|.|.|..|.
Human   282 --------------KLQTLSPALKAPEKTRETGLS--------------------YTEDDKKASP 312

  Fly   350 DMKIKLRLSERRRSVRL-ASMDVDPLSLEEAVQEPNAQGRKRLGVANGDIYHTPTKKSKEPLESA 413
            :.:|.||       .|: ||..:|  ..||....| ..|.:|..|....|......|.::..|:.
Human   313 EHRIILR-------TRIAASKTID--IREERTLTP-ISGGQRSSVVPSVILKPENIKKRDAKEAK 367

  Fly   414 AATEQTPSTRRKSILKSATSRLAEGTPRRSIH-LSNIVEQRVFEDDEIISTPKRGRSKKTVQDND 477
            |..|.|.:..|   ::..:|.|.....|:.:. |.|....:  |:.||:...:...|.   .|.:
Human   368 AQNEATSTPHR---IRRKSSVLTMNRIRQQLRFLGNSKSDQ--EEKEILPAAEISDSS---SDEE 424

  Fly   478 EDYSP--KKSVQKTPTRTRRSS------TTTKTATTPSKGITTATATPMTPSQKMKKIRAGELSP 534
            |..:|  .:...:|.:|..|||      |.||   .|.|.:     .|.||.....:||:..|
Human   425 EASTPPLPRRAPRTVSRNLRSSLKSSLHTLTK---VPKKSL-----KPRTPRCAAPQIRSRSL-- 479

  Fly   535 SMQQRTDLPAKDSSKSELQLAREQLHVSVVPKSLPCREREFENIYAFLEGKIQDQCGGCMYVSGV 599
                     |.....|.|:.||.:||||.||:||||||:||::||.|:|.|:.|..|||||:|||
Human   480 ---------AAQEPASVLEEARLRLHVSAVPESLPCREQEFQDIYNFVESKLLDHTGGCMYISGV 535

  Fly   600 PGTGKTATVTGVIRTLQRMAKQNELPAFEYLEINGMRLTEPRQAYVQIYKQLTGKTVSWEQAHAL 664
            |||||||||..|||.||:.|:.|::|.|:|:|:|||:||||.|.||||.::|||:..:...|..|
Human   536 PGTGKTATVHEVIRCLQQAAQANDVPPFQYIEVNGMKLTEPHQVYVQILQKLTGQKATANHAAEL 600

  Fly   665 LEKRFTTPAPRRVTTVLLVDELDILCNRRQDVVYNLLDWPTKSAAKLVVVTIANTMDLPERLLMG 729
            |.|:|.|....:.||||||||||:|...:||::|||.||||...|:|||:.||||||||||::|.
Human   601 LAKQFCTRGSPQETTVLLVDELDLLWTHKQDIMYNLFDWPTHKEARLVVLAIANTMDLPERIMMN 665

  Fly   730 KVTSRLGLTRLTFQPYSHKQLQEIVTARLGGSETFKGEAVQLVARKVAAVSGDARRALDICRRAT 794
            :|:|||||||:.||||::.|||:|:.:||...:.|:.:|:|||||||||:||||||.||||||||
Human   666 RVSSRLGLTRMCFQPYTYSQLQQILRSRLKHLKAFEDDAIQLVARKVAALSGDARRCLDICRRAT 730

  Fly   795 EIADTAAVK-----CVTMLHVQQALAEMIASAKVQAIRNCSRMEQIFLQAIAAEVTRTGVEETTF 854
            ||.:.:..|     .||:.|..:|:.||.:|:.:.||:|.|.:||.||:||.||..|:|:||.||
Human   731 EICEFSQQKPDSPGLVTIAHSMEAVDEMFSSSYITAIKNSSVLEQSFLRAILAEFRRSGLEEATF 795

  Fly   855 MGVYQQVETIAAFMGVTFPPPGRALRLCSKLGAERLIISEHSRNDLFQKILLNVSADDIHYALRV 919
            ..:|.|...:....|:.:|.....:.:||.||:.||::.|.|||||..::.||||.||:.|||:.
Human   796 QQIYSQHVALCRMEGLPYPTMSETMAVCSHLGSCRLLLVEPSRNDLLLRVRLNVSQDDVLYALKD 860

  Fly   920 E 920
            |
Human   861 E 861

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Orc1	NP_477303.1	BAH_Orc1p_animal	44..185	CDD:240070	25/168 (15%)
		AAA	591..741	CDD:214640	92/149 (62%)
		AAA	594..739	CDD:278434	87/144 (60%)
		Cdc6_C	837..917	CDD:215013	34/79 (43%)
ORC1	NP_001177747.1	BAH_Orc1p_animal	44..170	CDD:240070	26/171 (15%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	183..233		11/50 (22%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	269..312		14/78 (18%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	360..382		5/24 (21%)
		rne	<362..>487	CDD:236766	34/151 (23%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	412..476		18/74 (24%)
		PTZ00112	<495..743	CDD:240274	150/247 (61%)
		Necessary and sufficient for ORC complex assembly	501..861		195/359 (54%)
		Cdc6_C	778..857	CDD:401137	33/78 (42%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165147099
Domainoid	1	1.000	178	1.000	Domainoid score	I3575
eggNOG	1	0.900	-	-		E1_COG1474
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	415	1.000	Inparanoid score	I1842
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D427050at33208
OrthoFinder	1	1.000	-	-		FOG0003590
OrthoInspector	1	1.000	-	-		oto90381
orthoMCL	1	0.900	-	-		OOG6_100406
Panther	1	1.100	-	-	LDO	PTHR10763
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R177
SonicParanoid	1	1.000	-	-		X2463
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	15	14.790