DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Orc1 and Cdc6

DIOPT Version :9

Sequence 1:	NP_477303.1	Gene:	Orc1 / 35686	FlyBaseID:	FBgn0286788	Length:	924	Species:	Drosophila melanogaster
Sequence 2:	NP_648247.1	Gene:	Cdc6 / 38989	FlyBaseID:	FBgn0035918	Length:	662	Species:	Drosophila melanogaster

Alignment Length:	767	Identity:	184/767 - (23%)
Similarity:	309/767 - (40%)	Gaps:	235/767 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly   271 RSVVRLSEKKNAPEINANYLPASPLTEKNAKVETPKSRASAARRNLNLSLDRGADTTADSDCLNY 335
            |...|||....|       ..||||.   ...:||:......||.....|   ||:..:.:.:
  Fly     5 RRSTRLSSISKA-------TAASPLP---PSTQTPRRSEVWKRRQPKKVL---ADSDEEEEVV-- 54

  Fly   336 SIVQQTPDPKTPSNDMKIKL----RLSERRRSVRLASMDVDPLSLEEAVQEPNAQGRKRLGVANG 396
            :.:.....|.:.:|:.:..|    ::|.||.|                          ::.||..
  Fly    55 TAIYDLTSPVSENNENRNVLNKMDKISRRRTS--------------------------QVQVAQS 93

  Fly   397 DIYHTPTKKSKEPLESAAATEQTPSTRRKSILKSATSRLAEG----------------------- 438
            ::..|| :.:|:.::||.::.    .:|:...:.||:|..||
  Fly    94 ELPKTP-RSTKKTVQSAGSSR----AKREEENREATARFLEGEQDSEVDPLHGSPPKQRKLQPLP 153

  Fly   439 ----TPRRSIHLSNIVEQRVFEDDEIISTPKRGRS-----KKTVQD-------NDEDYSPKKSVQ 487
                :|.|.:...:|.|:   :::|:.:|..:..:     |...:|       ..||...:|..:
  Fly   154 QHLISPSRLLDRLSIDER---QEEEVEATTHKTETAEQQPKHQAKDEAKPRPKQQEDPLAQKQQE 215

  Fly   488 KTPTRTRRSSTTTKTATTPSKGITTATATPMTPSQKMKKIRAGELSPSMQQRTDLPAKDSSKSEL 552
            |.||:     ...|..|.....|.|...|                     |:.:||:  .|:::.
  Fly   216 KPPTK-----QPNKNQTKEKSNIQTNEET---------------------QQNNLPS--PSRNKY 252

  Fly   553 QLAREQLHVSVVPKSLPCREREFENIYAFLEGKIQDQCGGCMYVSGVPGTGKTATVTGVIR---- 613
            |.||..|: |...::||.||.:.:.:..|....::.|..|.:||||.|||||||.::.::|
  Fly   253 QNARRVLN-SAETQNLPGRESQLQELREFFSNHLESQTSGSLYVSGQPGTGKTACLSLLLRDPDF 316

  Fly   614 --TLQRMAKQNELPAFEYLEINGMRLTEPRQAYVQIYKQL----TGKTVSWEQAHALLEKRFTTP 672
              .|||            :.||...:......|.::..:|    :|:|   |:.|....:|....
  Fly   317 SKRLQR------------VYINCTSIASVGAVYKKLCTELQLKVSGRT---ERDHLEAIQRHLKT 366

  Fly   673 APRRVTTVLLVDELDILCNRRQDVVYNLLDWPTKSAAKLVVVTIANTMDLPERLLMGKVTSRLGL 737
            |.|.:  :|::||:|.||..||:|:|.:.:||....:::::|.|||::||.:|.|| ::.:|..|
  Fly   367 AKRML--LLVLDEIDQLCTSRQEVLYTIFEWPALPGSRILLVGIANSLDLTDRALM-RLNARCEL 428

  Fly   738 -TRLT-FQPYSHKQLQEIVTARLGGSE---TFKGEAVQLVARKVAAVSGDARRALDICRRATEIA 797
             .||. |.|||.:|:.||..:||..:|   .|....:||:|.||:|:|||.||||||.||..|||
  Fly   429 KPRLMHFPPYSKQQIVEIFKSRLAEAEVLDVFPPVTLQLLAAKVSAISGDVRRALDIGRRVVEIA 493

  Fly   798 D-----------------------TAAVKCVTMLHVQ---------------QALAEMI-ASAKV 823
            :                       .|..|..|:..||               |.|.|.| ||..:
  Fly   494 EQQKRDGEKEFNMKALQLEGKDAVEAKEKQDTLKPVQVTQVAAVLNKVYGASQNLEEDIEASFPL 558

  Fly   824 Q----------AIRN-------CSRMEQIFLQAIAAEVTRTGVEETTFMGVYQQVETIAAFMGVT 871
            |          .:||       ..|:.::: :.:.|:.....:::..|.|....|||    .|:
  Fly   559 QQKLMLCTLVLMLRNERNKDISMGRLHEVY-RRVCAKRNILALDQAEFTGTVDLVET----RGI- 617

  Fly   872 FPPPGRALRLCSKLGAERLIISEHSRNDLFQKILLNVSADDIHYALRVEEMV 923
                   ||:..|            :.....|:||....:::|.||..::::
  Fly   618 -------LRIMRK------------KEPRLHKVLLQWDEEEVHAALSDKQLI 650

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Orc1	NP_477303.1	BAH_Orc1p_animal	44..185	CDD:240070
		AAA	591..741	CDD:214640	51/160 (32%)
		AAA	594..739	CDD:278434	49/155 (32%)
		Cdc6_C	837..917	CDD:215013	14/79 (18%)
Cdc6	NP_648247.1	TIGR02928	266..623	CDD:274354	113/387 (29%)
		AAA_22	288..407	CDD:290137	40/135 (30%)
		Cdc6_C	564..644	CDD:215013	17/104 (16%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45448992
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1474
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D38432at33392
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100406
Panther	1	1.100	-	-	P	PTHR10763
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R177
SonicParanoid	0	0.000	Not matched by this tool.
	7	6.780